DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Chrna6 and nAChRbeta1

DIOPT Version :9

Sequence 1:	NP_067344.2	Gene:	Chrna6 / 11440	MGIID:	106213	Length:	494	Species:	Mus musculus
Sequence 2:	NP_523927.2	Gene:	nAChRbeta1 / 38545	FlyBaseID:	FBgn0000038	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	211/494 - (42%)
Similarity:	316/494 - (63%)	Gaps:	27/494 - (5%)

- Green bases have known domain annotations that are detailed below.

Mouse    17 W-LCGFLAL--FKGSTGCESEEQLFHRLFAHYNRFIRPVENVSDPVTVHFELAITQLANVDEVNQ 78
            | ||..|.|  |...:..|.||:|...||..||:.||||:|::..|.|.|.||..||.||:|.||
  Fly     8 WLLCSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQ 72

Mouse    79 IMETNLWLRHIWKDYRLRWDPTEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALLKYD 143
            ||::|:|||.:|.||:|:||..:|.||..||:|.|.:|||||||:|||.|:::|..|:..|:...
  Fly    73 IMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPT 137

Mouse   144 GVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSK--VDMNDFWENSEW 206
            |.:.|.||||::|||.:|:|:||||.|.|.:||||||::..::.|.:..:|  ||::|:|::..|
  Fly   138 GEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTW 202

Mouse   207 EIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEK 271
            :|::...|.:..:.:......||||:...|||..:|||:|||:|.:.||||.|||||||::.|||
  Fly   203 DIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEK 267

Mouse   272 VTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATHT 336
            |||.||:||||.||||::::.:|.||||:||:.:|||||.|..|:||:|||.::|.::|.|.||.
  Fly   268 VTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHR 332

Mouse   337 MPKWVKTIFLQAFPSILMMRKPLDKTK-----EAGGVKDPK-------SHTKRPAKVKFTHRGES 389
            ||.::::|||...|:.|.|::| .||:     |..|:..|.       |..:.|..:......:|
  Fly   333 MPMYIRSIFLHYLPAFLFMKRP-RKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQS 396

Mouse   390 KL----LKECHH--CQKSSDIAPGKRRSSQQPARWVAENSEH---SSDVEDVIESVQFIAENMKS 445
            |:    |.:.||  |:.:..:..|.........|..:|:|:.   |.:.....|:|:||||::::
  Fly   397 KMEVMELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRN 461

Mouse   446 HNETNEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVGLFL 484
            .:...:..:||||:|||:||:.|::|.||...||||:.:
  Fly   462 EDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILM 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chrna6	NP_067344.2	LIC	15..484	CDD:273305	211/492 (43%)
		Neur_chan_LBD	34..240	CDD:280998	96/207 (46%)
		Neur_chan_memb	247..483	CDD:280999	104/256 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..423		3/23 (13%)
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	211/492 (43%)
		Neur_chan_LBD	28..236	CDD:280998	96/207 (46%)
		Neur_chan_memb	243..498	CDD:280999	103/255 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920