Protein Alignment Chrna6 and nAChRalpha6

DIOPT Version :9

• Sequence 1: NP_067344.2
• Gene: Chrna6 / 11440
• MGIID: 106213
• Length: 494
• Species: Mus musculus
• Sequence 2: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Alignment Length: 511
• Identity: 195/511 - (38%)
• Similarity: 287/511 - (56%)
• Gaps: 59/511 - (11%)

Mouse    21 FLALFKGSTGCESEEQLFHRLFAHYNRFIRPVENVSDPVTVHFELAITQLANVDEVNQIMETNLW 85
            |||:.|.|.....|::|.:.|.:.||...|||.|.|:|:.|.|.|.:.|:.:|||.|||:.||.|
  Fly    17 FLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTTNAW 81

Mouse    86 LRHIWKDYRLRWDPTEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALLKYDGVITWTP 150
            |...|.||.|||:.|||.|::.||:..:.:||||:::||:|...|.....|..::|::|...:.|
  Fly    82 LNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCLYVP 146

Mouse   151 PAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSK--VDMNDFWENSEWEIVDASG 213
            |.||||:|.:|||:||||.|:|.:||||||||..::| |::.|:  .|::||..|.||.::...|
  Fly   147 PGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLD-LVLNSEDGGDLSDFITNGEWYLLAMPG 210

Mouse   214 YKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISV 278
            .|:.|.|.||.|.|.|||::..|||..::|..|||:||:.||.:.:|.|.||.|.|||:||.:::
  Fly   211 KKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDSGEKLTLGVTI 275

Mouse   279 LLSLTVFLLVITETIPSTSLVIPLVGEYLLFT-----------------------------MIFV 314
            ||||||||.::.|::|:||..:||:|..:|.:                             |..|
  Fly   276 LLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLGTYFNCIMFMV 340

Mouse   315 TLSIVVTVFVLNIHYRTPATHTMPKWVKTIFLQAFPSILMMRKPLDKTKEAGGVKDPKSH---TK 376
            ..|:|:||.|||.|:||...|.||.|:|::|||..|.||.|.:|        |.|..:..   :.
  Fly   341 ASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRP--------GRKITRKTILLSN 397

Mouse   377 RPAKVKFTHRGESKLL-------KECHHCQKSSDIAPGKRRSSQQPARWVAENSEHSS------D 428
            |..:::...|....||       .:..|....|..|.|...|..:|.. |.|:  |::      |
  Fly   398 RMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTT-VEEH--HTAIGCNHKD 459

Mouse   429 VEDVIESVQFIAENMKSHNETNEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVGLFL 484
            :..:::.:|||...|:..::..|:..|||:.||||||..|.||.:..:..||.:.|
  Fly   460 LHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLL 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chrna6	NP_067344.2	LIC	15..484	CDD:273305	194/509 (38%)
		Neur_chan_LBD	34..240	CDD:280998	95/207 (46%)
		Neur_chan_memb	247..483	CDD:280999	92/280 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..423		7/23 (30%)
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	195/511 (38%)
		LGIC_ECD_nAChR	55..236	CDD:349798	83/181 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910