Protein Alignment Chrna4 and nAChRbeta1

DIOPT Version :9

• Sequence 1: NP_056545.3
• Gene: Chrna4 / 11438
• MGIID: 87888
• Length: 629
• Species: Mus musculus
• Sequence 2: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 611
• Identity: 239/611 - (39%)
• Similarity: 329/611 - (53%)
• Gaps: 121/611 - (19%)

Mouse    13 LLLPLLLLLGTGLLPASSHIETRAHAEERLLKRLFSGYNKWSRPVANISDVVLVRFGLSIAQLID 77
            ||..:|:|:...|:.||..       ||||::.||.||||..|||.|::..|.|||||:..|||:
  Fly     9 LLCSILVLVAFSLVSASED-------EERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLIN 66

Mouse    78 VDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTK 142
            |:||||:|.:|||::..|:||:|:||..||..:..:|:|.:.:|:|||||:|||||::.|.:.:.
  Fly    67 VNEKNQIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSN 131

Mouse   143 AHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTY--DKAKIDLVSMHSRVDQLDF 205
            ..::..|.|.|.|||||:|||:||||:||||||.|.|||||||:  |:..:.|.:..:.||..|:
  Fly   132 VLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDY 196

Mouse   206 WESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFIIRRLPLFYTINLIIPCLLISCLTVLVFYLP 270
            |:||.|.|::.....|..:.:.......|||:..||||..||||:|||:|.:|||.|.|||||||
  Fly   197 WKSGTWDIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLP 261

Mouse   271 SECGEKVTLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHR 335
            :|.||||||.||:||||.|||||:::|:|.||||:|||.:|||||.|..|:||::||.::|.:.|
  Fly   262 AEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFR 326

Mouse   336 SPRTHTMPAWVRRVFLDIVPRLLFMKRPSVVKDNCRRLIESMHKMANAPRFWPEPESEPGILGDI 400
            .||||.||.::|.:||..:|..||||||.  |...|.::|
  Fly   327 GPRTHRMPMYIRSIFLHYLPAFLFMKRPR--KTRLRWMME------------------------- 364

Mouse   401 CNQGLSPAPTFCNRMDTAVETQPTCRSPSHKVPDLKTSEVEKASPCPSPGSCHPPNSSGAPVLIK 465
                                 .|....|:|..|..       .||...|.  |.....|....::
  Fly   365 ---------------------MPGMSMPAHPHPSY-------GSPAELPK--HISAIGGKQSKME 399

Mouse   466 ARSLSVQHVPSSQEAAEGSIRCRSRSIQYCVSQDGAASLTESKPTGSPASLKTRPSQLPVSDQTS 530
            ...||..|.|:          |:   |...|:..|...|.:.
  Fly   400 VMELSDLHHPN----------CK---INRKVNSGGELGLGDG----------------------- 428

Mouse   531 PCKCTCKEPSPVSPITVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKY 595
                 |:..|..|              ..:.|||..::|.|.|::||:||:.||.....:|||||
  Fly   429 -----CRRESESS--------------DSILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKY 474

Mouse   596 VAMVIDRIFLWMFIIVCLLGTVGLFL 621
            |||||||:.|::|.||...||||:.:
  Fly   475 VAMVIDRLQLYIFFIVTTAGTVGILM 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chrna4	NP_056545.3	Neur_chan_LBD	39..245	CDD:280998	101/207 (49%)
		Neur_chan_memb	252..620	CDD:280999	126/367 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..459		8/38 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	503..529		1/25 (4%)
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	239/609 (39%)
		Neur_chan_LBD	28..236	CDD:280998	101/207 (49%)
		Neur_chan_memb	243..498	CDD:280999	125/366 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H592
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810