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Protein Alignment Aco2 and mAcon1

DIOPT Version :9

Sequence 1:	NP_542364.1	Gene:	Aco2 / 11429	MGIID:	87880	Length:	780	Species:	Mus musculus
Sequence 2:	NP_001097186.2	Gene:	mAcon1 / 44149	FlyBaseID:	FBgn0010100	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	781	Identity:	562/781 - (71%)
Similarity:	648/781 - (82%)	Gaps:	13/781 - (1%)

- Green bases have known domain annotations that are detailed below.

Mouse     8 VTRLQK-----ALGVRQYHVASVLCQRA-KVAMSHFEPSEYIRYDLLEKNINIVRKRLNRPLTLS 66
            |.||.|     |..|||:|.:   |..| |||:|.|:...|:.|:.|.|.:.:||.|||||||||
  Fly    12 VCRLGKHVASEATVVRQFHAS---CYTASKVALSKFDSDVYLPYEKLNKRLEVVRGRLNRPLTLS 73

Mouse    67 EKIVYGHLDDPANQEIERGKTYLRLRPDRVAMQDATAQMAMLQFISSGLPKVAVPSTIHCDHLIE 131
            ||::|.||||||||:|.||.:|||||||||||||||||||:||||||||.|||||||:|||||||
  Fly    74 EKVLYSHLDDPANQDIVRGTSYLRLRPDRVAMQDATAQMALLQFISSGLKKVAVPSTVHCDHLIE 138

Mouse   132 AQVGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWRPGSGIIHQIILENYAYPGVLLIGTDSHTP 196
            ||:||.|||.||||:|:|||:|||:..||||:|||:|||||||||||||||:||:|:||||||||
  Fly   139 AQIGGPKDLARAKDLNKEVYDFLASTCAKYGLGFWKPGSGIIHQIILENYAFPGLLMIGTDSHTP 203

Mouse   197 NGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWTSPKDVILKVAGILTVKGGT 261
            |||||||:||||||||||||||.|||||||||||||.|||.:||||||||||||||.||||||||
  Fly   204 NGGGLGGLCIGVGGADAVDVMADIPWELKCPKVIGVNLTGKISGWTSPKDVILKVADILTVKGGT 268

Mouse   262 GAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRTDIANLAEEFKDHL 326
            |||:||||.|||||||||||||||||||||||||:||:|.||..||..|||..||:.|::::..:
  Fly   269 GAIIEYHGKGVDSISCTGMATICNMGAEIGATTSLFPFNQRMADYLKSTGRAGIASEAQKYQAKI 333

Mouse   327 V-PDPGCQYDQVIEINLNELKPHINGPFTPDLAHPVADVGTVAEKEGWPLDIRVGLIGSCTNSSY 390
            : .|..|:||::|||||:.|:||:||||||||.||::.:|..::|.|:|:|||||||||||||||
  Fly   334 LSADKNCEYDELIEINLDTLEPHVNGPFTPDLGHPISKLGENSKKNGYPMDIRVGLIGSCTNSSY 398

Mouse   391 EDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAQILRDVGGIVLANACGPCIGQW 455
            |||||.|::||.|::||||.|..|.:|||||||||||||||.:::....||.|||||||||||||
  Fly   399 EDMGRCASIAKDAMSHGLKSKIPFNVTPGSEQIRATIERDGISEVFDKFGGTVLANACGPCIGQW 463

Mouse   456 DRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDFLTGKDGK 520
            ||||:|||:||||||||||||||||||||.||.||||||:||||:|||.|.|||.||.|||.|||
  Fly   464 DRKDVKKGDKNTIVTSYNRNFTGRNDANPATHCFVTSPELVTALSIAGRLDFNPLTDELTGADGK 528

Mouse   521 KFKLEAPDADELPRSDFDPGQDTYQHPPKDSSGQRVDVSPTSQRLQLLEPFDKWDGKDLEDLQIL 585
            ||||:||..||||...||||||||..||......:|.|.|.|.|||||||||||:|:||.||.:|
  Fly   529 KFKLKAPFGDELPAKGFDPGQDTYTAPPPSGENVKVAVDPKSTRLQLLEPFDKWNGQDLTDLTVL 593

Mouse   586 IKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYY 650
            ||||||||||||||||||||:||||||||||:.|||.|.||.:.|:::|.....:|.|||.||.|
  Fly   594 IKVKGKCTTDHISAAGPWLKYRGHLDNISNNMFIGATNYENNEMNNIKNQRNGSWGGVPDVARDY 658

Mouse   651 KKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPSDY 715
            |.:||:||.:|||||||||||||||||||||||||||.||||||||||||||||||||||:|:||
  Fly   659 KANGIKWVAVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGLLPLTFANPADY 723

Mouse   716 NKIHPVDKLTIQGLKDFAPGKPLKCVIKHPNGTQ-ETILLNHTFNETQIEWFRAGSALNRMKELQ 779
            :||.|..|:::..||..|||||:...||  ||.: |.|.||||.|:.||.||:|||||||||||.
  Fly   724 DKIQPTSKISLLNLKSLAPGKPVDAEIK--NGDKVERIKLNHTLNDLQIGWFKAGSALNRMKELA 786

Mouse   780 Q 780
            |
  Fly   787 Q 787

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.