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Protein Alignment Aco1 and mAcon1

DIOPT Version :9

Sequence 1:	NP_031412.2	Gene:	Aco1 / 11428	MGIID:	87879	Length:	889	Species:	Mus musculus
Sequence 2:	NP_001097186.2	Gene:	mAcon1 / 44149	FlyBaseID:	FBgn0010100	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	838	Identity:	239/838 - (28%)
Similarity:	357/838 - (42%)	Gaps:	176/838 - (21%)

- Green bases have known domain annotations that are detailed below.

Mouse    79 KPARVILQDFTGVPAVVDFAAMRDAVKKLGGNPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQ 143
            :|.||.:||.|...|::.|  :...:||:         ..|:.:..||.|:.......| |.:.:
  Fly    99 RPDRVAMQDATAQMALLQF--ISSGLKKV---------AVPSTVHCDHLIEAQIGGPKD-LARAK 151

Mouse   144 DLEFERNKERFEFL-----KWGSQAFCNMRIIPPGSGIIHQVNLEYLARVVFDQDGCYYPDSL-V 202
            ||    |||.::||     |:|      :....||||||||:.||..|          :|..| :
  Fly   152 DL----NKEVYDFLASTCAKYG------LGFWKPGSGIIHQIILENYA----------FPGLLMI 196

Mouse   203 GTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLPQVIGYKLMGKPHPLVTSTDIVLTITKH 267
            ||||||....|||.|..||||.:|..||...|..:..|:|||..|.||.....:..|::|.:...
  Fly   197 GTDSHTPNGGGLGGLCIGVGGADAVDVMADIPWELKCPKVIGVNLTGKISGWTSPKDVILKVADI 261

Mouse   268 LRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSIAYLLQTGREEDKVKH 332
            |...|..|..:|:.|.||..:|....|||.||..|.|||.:.||.::....||..||| ......
  Fly   262 LTVKGGTGAIIEYHGKGVDSISCTGMATICNMGAEIGATTSLFPFNQRMADYLKSTGR-AGIASE 325

Mouse   333 IQKYLQAVGMFRDFNDTSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSEMKKDFESCLGAKQ 397
            .||| ||..:..|.|     .::.:::|::|.|:.|..:||..|.....:|:        ||...
  Fly   326 AQKY-QAKILSADKN-----CEYDELIEINLDTLEPHVNGPFTPDLGHPISK--------LGENS 376

Mouse   398 GFKGFQVAPDRHNDRKTFLYSNSEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVEAGLS 462
            ...|:.:                       .:.:..|.||||:|... |.....:||.|:..||.
  Fly   377 KKNGYPM-----------------------DIRVGLIGSCTNSSYED-MGRCASIAKDAMSHGLK 417

Mouse   463 VKPYIKTSLSPGSGVVTYYLRESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLV 527
            .|  |..:::|||..:...:...|:.....:.|..|:...|..|||....      :.:.:||..
  Fly   418 SK--IPFNVTPGSEQIRATIERDGISEVFDKFGGTVLANACGPCIGQWDR------KDVKKGDKN 474

Mouse   528 AVGVLSGNRNFEGR--VHPNTRANYLASPPLVIAYAIAGTVRIDFEKEPLG---VNAQGRQVFLK 587
            .: |.|.||||.||  .:|.|.. ::.||.||.|.:|||  |:||  .||.   ..|.|::..||
  Fly   475 TI-VTSYNRNFTGRNDANPATHC-FVTSPELVTALSIAG--RLDF--NPLTDELTGADGKKFKLK 533

Mouse   588 DIWPTRDEIQAVERQHVIPGMFKEVYQKIETVNKSWNALAAPSEKL-YAWNPKSTYIK-SPPFFE 650
            .  |..||:.|   :...||            ..::.|.....|.: .|.:||||.:: ..||
  Fly   534 A--PFGDELPA---KGFDPG------------QDTYTAPPPSGENVKVAVDPKSTRLQLLEPF-- 579

Mouse   651 SLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAG----------NIARNS--PAARYLTNRGLTP 703
                |....:.:.|..||:.:....||||||.||          ||:.|.  .|..|..|
  Fly   580 ----DKWNGQDLTDLTVLIKVKGKCTTDHISAAGPWLKYRGHLDNISNNMFIGATNYENN----- 635

Mouse   704 REFNSYGSRRGNDAIMARGTFANIRLLNKFLNKQAPQTVHLPSGETLDVFDAAERYQQAGLPLIV 768
             |.|:..::|                                :|....|.|.|..|:..|:..:.
  Fly   636 -EMNNIKNQR--------------------------------NGSWGGVPDVARDYKANGIKWVA 667

Mouse   769 LAGKEYGSGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGETADSLGLTGRE 833
            :..:.||.||||:.||..|..||.:|::.:|:.|||.:||...|::||.:......|.:..|.:.
  Fly   668 VGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGLLPLTFANPADYDKIQPTSKI 732

Mouse   834 RYTINIPEDLKPRMTVQIKLDTGKTFQAVMRFDT--DVELTYFHNGGILNYMIRKMAQ 889
            . .:|: :.|.|...|..::..|...:.:....|  |:::.:|..|..||.| :::||
  Fly   733 S-LLNL-KSLAPGKPVDAEIKNGDKVERIKLNHTLNDLQIGWFKAGSALNRM-KELAQ 787

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.