DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ace and Ance

DIOPT Version :9

Sequence 1:	NP_997507.1	Gene:	Ace / 11421	MGIID:	87874	Length:	1312	Species:	Mus musculus
Sequence 2:	NP_001285915.1	Gene:	Ance / 34805	FlyBaseID:	FBgn0012037	Length:	615	Species:	Drosophila melanogaster

Alignment Length:	593	Identity:	260/593 - (43%)
Similarity:	367/593 - (61%)	Gaps:	9/593 - (1%)

- Green bases have known domain annotations that are detailed below.

Mouse   647 LETDEAKADRFVEEYDRTAQVLLNEYAEANWQYNTNITIEGSKILLEKSTEVSNHTLKYGTRAKT 711
            |..:|.:|..::|..::......|...||.|.|.:|||.|..|...|.|.|::....:..:....
  Fly    18 LVKEEIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTK 82

Mouse   712 FDVSNFQNSSIKRIIKKLQNLDRAVLPPKELEEYNQILLDMETTYSLSNIC-YTNGT-C-MPLEP 773
            |...::|:..:||..|.|..|..|.||..:..|....|..||:.::...:| |.:.| | :.|:|
  Fly    83 FQWRSYQSEDLKRQFKALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDP 147

Mouse   774 DLTNMMATSRKYEELLWAWKSWRDKVGRAILPFFPKYVEFSNKIAKLNGYTDAGDSWRSLYESDN 838
            ::..:::.||.:|||.:.|:.:.||.|.|:...|.:|||.:.|.||||.:|...::|...||.|.
  Fly   148 EIEEVISKSRDHEELAYYWREFYDKAGTAVRSQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDT 212

Mouse   839 LEQDLEKLYQELQPLYLNLHAYVRRSLHRHYGSEYINLDGPIPAHLLGNMWAQTWSNIYDLVAPF 903
            .||.||.::.:::|||..:|.|||..|.:|||...::..||||.|||||||||.||.|.|:|:||
  Fly   213 FEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHLLGNMWAQQWSEIADIVSPF 277

Mouse   904 PSAPNIDATEAMIKQGWTPRRIFKEADNFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHPSAWD 968
            |..|.:|.:..|.|||:||.::|:..|:||||:.|..:|.:||:||::|||||||::|||.||||
  Fly   278 PEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVCHASAWD 342

Mouse   969 FYNGKDFRIKQCTSVNMEDLVIAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDIMALSVST 1033
            ||...|.||||||.|..:.|...|||:||||||:||:..|..:|.|||||||||:||:::|||||
  Fly   343 FYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVST 407

Mouse  1034 PKHLYSLNLLSTEGSGYEYDINFLMKMALDKIAFIPFSYLIDQWRWRVFDGSITKENYNQEWWSL 1098
            ||||..:.||.......|..||.|...|||||.|:||::.:|::||.:|.|.:.|.|:|..:|.|
  Fly   408 PKHLEKIGLLKDYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKL 472

Mouse  1099 RLKYQGLCPPVPRSQGDFDPGSKFHVPANVPYVRYFVSFIIQFQFHEALCRAAGHTG------PL 1157
            |.:|.|:.|||.||:.|||..:|:|:.|:|.|:||.|||||||||:::.|..||...      ||
  Fly   473 RDEYSGIEPPVVRSEKDFDAPAKYHISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPL 537

Mouse  1158 HKCDIYQSKEAGKLLADAMKLGYSKPWPEAMKLITGQPNMSASAMMNYFKPLTEWLVTENRRHGE 1222
            ..||||.|..||....:.:.:|.|||||:|::...|:..||..|:..||:||..||..||.::..
  Fly   538 DNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERIMSGKAIAEYFEPLRVWLEAENIKNNV 602

Mouse  1223 TLGWPEYN 1230
            .:||...|
  Fly   603 HIGWTTSN 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ace	NP_997507.1	Peptidase M2 1	35..635
		Peptidase_M2	45..628	CDD:279709
		Peptidase M2 2	636..1237		260/593 (44%)
		Peptidase_M2	649..1226	CDD:279709	256/585 (44%)
Ance	NP_001285915.1	Peptidase_M2	19..606	CDD:279709	256/586 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	533	1.000	Domainoid score	I283
eggNOG	1	0.900	-	-		E1_KOG3690
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	1	1.000	-	-		mtm8699
orthoMCL	1	0.900	-	-		OOG6_101615
Panther	1	1.100	-	-	O	PTHR10514
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2384
SonicParanoid	1	1.000	-	-		X1436
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.800