DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SIGLEC11 and sma-10

DIOPT Version :9

Sequence 1:	NP_443116.2	Gene:	SIGLEC11 / 114132	HGNCID:	15622	Length:	698	Species:	Homo sapiens
Sequence 2:	NP_499896.1	Gene:	sma-10 / 176849	WormBaseID:	WBGene00020649	Length:	881	Species:	Caenorhabditis elegans

Alignment Length:	698	Identity:	134/698 - (19%)
Similarity:	221/698 - (31%)	Gaps:	210/698 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    20 LPVLGAGSLNKDPSY----------------SLQVQRQVPVPE----GLCVIVSCNLSYPR---- 60
            ||.|...||.::..|                :|...|...|.|    ||..:...:|||.:
Worm   242 LPSLQNVSLARNDVYRLDDGMFYACEGLKHLNLSTNRVQAVTEGWMFGLTSLEVLDLSYNQIQSF 306

Human    61 --DGWDESTAAYGYWFKGRTSPKTGAPVATNNQSREVE--------MSTRDRFQLTG-------D 108
              ..|..:...  .|....::.....|..:....|::|        :.:..:|.|.|       |
Worm   307 HISSWSHTPKL--KWLSLHSNRIQSLPSGSFRVLRQLEELILSANSIDSLHKFALVGMSSLHKLD 369

Human   109 PGKGSCSLVIRD-AQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTA-----LTKKPDVYI-PET 166
            ....:.::.:.| |...:.:..|.|..|.:..:...:....|.:..|     ||..|...| ||.
Worm   370 LSSNTLAVCVEDGAVLYNTSMPFLRSLRFTNNQLRVIPKRAFERFPALEELDLTDNPIATIHPEA 434

Human   167 LEP---------GQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQD- 221
            .||         ...:...|..:|.        .||.     .|.....:|..:..|:.|...|
Worm   435 FEPLELKRLVMNSSSILCDCQISWL--------ASWI-----YRLKLDKSSIIAKCSYPPPLADL 486

Human   222 ----HDT-DLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQ 281
                .|| :||||.|          :.|.::...|.::...|                     |:
Worm   487 YVVAIDTANLTCHND----------SPRAKIVRQPVEVSTLI---------------------GE 520

Human   282 FLRLLCAADSQPPATLSWVLQDRVLSSSHP----------------------WGPRTLG---LEL 321
            ..|..|......|.::.|    ||:.:..|                      :..|.|.   |.|
Worm   521 KARFTCNVYGASPLSIEW----RVMENGQPRVLVQDSATFLSINRTAVVNGTFDERELAAAELLL 581

Human   322 RGVRAGDSGRYTCRAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQS 386
            ..|...|:..|.|.|.||.||     |.|.     ::::.|.||.:...    ....:|:|.||:
Worm   582 DNVAMTDNSEYQCVARNRFGS-----DFST-----HVKLQVYQAPKFTY----TPEDMPLLVGQT 632

Human   387 LRLVCVTHSSPPARLSWTRWGQTVGPS--------QPSDPGVLELPPIQMEHEGEFTCHAQHPLG 443
            .:.:|....:|...:.|. :.|...|:        .|:|..:. :..:..|.:|.:||||.:..|
Worm   633 AKFLCAATGTPRPEIKWA-FEQIPFPAAEARRLYVTPNDDHIY-IMNVTKEDQGAYTCHATNVAG 695

Human   444 SQHVSLSLSV-----HYP--PQLLGPSCSWEAEGLHCSCSSQASPAPSLRWWLGEELLEGNSSQG 501
            ....|.:|.|     |||  |. |.|....:.:.|...||.....:.....|..::.:.....:.
Worm   696 QTQASANLIVFENFFHYPESPD-LSPMLIKKRDALKIDCSCDLISSRQRMVWKRQQQVILFLKKA 759

Human   502 SF----------EVTPSSAGP-----WANSSLSLH-----------GGLSSGLRLRCKAWNVHGA 540
            .|          :.|.|.:|.     |.:.::.:.           ..:||...|..:...:...
Worm   760 KFSDNDQILTLTQTTFSDSGEYSCELWVDDTILMRKITMVKVVNEDEFVSSEATLTQRVQRIRAM 824

Human   541 QSGSVFQLLPGKLEHGGGLGLGAALGA----------GVAALLAFCSC 578
            .|    :|:......|.|:.|.|:..|          .:...:|.|||
Worm   825 AS----KLVDNIKSTGNGIYLMASCSAFGLMILGVITSICICIAKCSC 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC11	NP_443116.2	Ig_Siglec_N	34..153	CDD:143189	25/160 (16%)
		IG_like	39..142	CDD:214653	22/128 (17%)
		IG_like	275..351	CDD:214653	22/100 (22%)
		IGc2	280..341	CDD:197706	19/85 (22%)
		IG_like	378..453	CDD:214653	20/82 (24%)
		Ig	387..450	CDD:143165	15/70 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..635
		ITIM motif	642..647
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..698
sma-10	NP_499896.1	LRRNT	29..54	CDD:214470
		leucine-rich repeat	55..77	CDD:275380
		LRR_8	78..135	CDD:290566
		LRR_4	78..116	CDD:289563
		leucine-rich repeat	78..101	CDD:275380
		LRR_RI	100..303	CDD:238064	15/60 (25%)
		leucine-rich repeat	102..124	CDD:275380
		leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	149..172	CDD:275380
		LRR_8	172..231	CDD:290566
		leucine-rich repeat	173..196	CDD:275380
		leucine-rich repeat	197..220	CDD:275380
		leucine-rich repeat	221..244	CDD:275380	1/1 (100%)
		LRR_8	243..303	CDD:290566	14/59 (24%)
		leucine-rich repeat	245..268	CDD:275380	4/22 (18%)
		LRR_RI	269..453	CDD:238064	33/185 (18%)
		leucine-rich repeat	269..292	CDD:275380	6/22 (27%)
		leucine-rich repeat	293..316	CDD:275380	4/22 (18%)
		LRR_8	315..373	CDD:290566	8/59 (14%)
		leucine-rich repeat	317..340	CDD:275380	2/24 (8%)
		leucine-rich repeat	341..364	CDD:275380	4/22 (18%)
		leucine-rich repeat	365..392	CDD:275380	3/26 (12%)
		LRR_8	393..450	CDD:290566	12/56 (21%)
		leucine-rich repeat	393..416	CDD:275380	3/22 (14%)
		leucine-rich repeat	417..438	CDD:275380	7/20 (35%)
		I-set	506..612	CDD:254352	25/140 (18%)
		Ig	522..606	CDD:143165	21/92 (23%)
		I-set	616..705	CDD:254352	20/94 (21%)
		Ig	633..705	CDD:299845	16/73 (22%)
		Ig	716..786	CDD:299845	11/70 (16%)
		IG	719..788	CDD:214652	10/68 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910