DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SIGLEC11 and meis1

DIOPT Version :9

Sequence 1:	NP_443116.2	Gene:	SIGLEC11 / 114132	HGNCID:	15622	Length:	698	Species:	Homo sapiens
Sequence 2:	XP_002931792.1	Gene:	meis1 / 100488182	XenbaseID:	XB-GENE-479439	Length:	465	Species:	Xenopus tropicalis

Alignment Length:	511	Identity:	99/511 - (19%)
Similarity:	142/511 - (27%)	Gaps:	230/511 - (45%)

- Green bases have known domain annotations that are detailed below.

Human   290 DSQPPATLSWV----LQDRVLSSSHPWGPRTLGL-----ELR-------GVRAGDSGRYTC---- 334
            ::.||:..|.|    .:|:.....||..| .|.|     ||.       ||..||    .|
Frog    57 NAMPPSMGSSVNDALKRDKDAIYGHPLFP-LLALIFEKCELATCTPREPGVAGGD----VCSSES 116

Human   335 ------------RAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSL-------- 379
                        |||..|.|....||        ||.:...|..|..|..|.....|
Frog   117 FNEDIAVFAKQIRAEKPLFSSNPELD--------NLMIQAIQVLRFHLLELEKVHELCDNFCHRY 173

Human   380 -PVLEGQ-SLRLVC-------------VTHSSP-PARLSW---------TRWGQTVGPSQPSDPG 419
             ..|:|: .:.||.             :|.|:| ..:.||         ||.|.|.|||
Frog   174 ISCLKGKMPIDLVIEDREGGSKSDSEDMTRSAPLTDQPSWSRDHDDTASTRSGGTPGPS------ 232

Human   420 VLELPPIQMEHEGEFTCHAQHPLGSQHVSLSLSVHYPPQLLGPSCSWEAEGLHCSCSSQASPAPS 484
                       .|..|.|:                      |.:.|.:.:||.   :|.|||:..
Frog   233 -----------SGGHTSHS----------------------GDNSSEQGDGLD---NSVASPSTG 261

Human   485 -------------------------LRWWLGEELLEGNSSQGSFEVTPSSAGPWANSSLSLHGGL 524
                                     :|.||.:.|.....|:..            ...|:...||
Frog   262 DDDDPDKDKKRHKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQ------------KKQLAQDTGL 314

Human   525 SSGLRLRCKAWNVHGAQ----------SGSVFQLLPGKLEHG--GGLGLGAALGAGVAALLAFCS 577
            :.   |:...|.::..:          :.:|.|..|...:..  ||..:......|:
Frog   315 TI---LQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNADGQPMGGFVMDGQQHMGI-------- 368

Human   578 CLVVFRVKICRKEARKRAAAEQDVP----STLGP--ISQG-----------HQHECSAGSSQDHP 625
                            ||...|.:|    |..||  :|.|           |..:...|:|
Frog   369 ----------------RAPGLQGMPGSYISPSGPMGMSMGQPSYTTSQMPLHHAQLRHGTS---- 413

Human   626 PPGAATYTPGKGEEQELHYASLSFQGLRLWEPADQEAPSTTEYSEIKIHTGQPLRG 681
               ..||.||     ..|:.::...|    .|.....|.:|....: ::||.|..|
Frog   414 ---VHTYIPG-----HHHHPAMMMHG----GPPHPGMPISTSSPSV-LNTGDPTMG 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC11	NP_443116.2	Ig_Siglec_N	34..153	CDD:143189
		IG_like	39..142	CDD:214653
		IG_like	275..351	CDD:214653	24/92 (26%)
		IGc2	280..341	CDD:197706	20/82 (24%)
		IG_like	378..453	CDD:214653	20/107 (19%)
		Ig	387..450	CDD:143165	17/85 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..635		12/55 (22%)
		ITIM motif	642..647		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..698		4/7 (57%)
meis1	XP_002931792.1	Meis_PKNOX_N	108..192	CDD:374576	21/95 (22%)
meis1	XP_002931792.1	Homeobox_KN	290..329	CDD:368670	9/53 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I35468
eggNOG	1	0.900	-	-		E1_2CYFK
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm54708
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.860