DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SIGLEC11 and siglecl2

DIOPT Version :9

Sequence 1:	NP_443116.2	Gene:	SIGLEC11 / 114132	HGNCID:	15622	Length:	698	Species:	Homo sapiens
Sequence 2:	NP_001120417.1	Gene:	siglecl2 / 100145501	XenbaseID:	XB-GENE-6462776	Length:	562	Species:	Xenopus tropicalis

Alignment Length:	662	Identity:	170/662 - (25%)
Similarity:	275/662 - (41%)	Gaps:	162/662 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    34 YSLQVQRQVPVPEGLCVIVSCNLSYPRDGWDESTAAYGYWFKGRTSPKTGAPVATNNQSREVEMS 98
            |.::...:|.|..||||.:.||.:...| :..:..|.|.|:||........|||.:..|.:...:
Frog    38 YKIEAPAEVTVQRGLCVHIPCNFTVGTD-FTLTRDAIGIWYKGYNGHFNKNPVAASTNSSQFPDT 101

Human    99 TRDRFQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPDVYI 163
            |..||..||....|.||..|.|||..|...|.||||.....:.::......:.||.| |:||:..
Frog   102 TNGRFIFTGKVSAGDCSFSISDAQPGDTDRYQFRVEDTGPSKFTYRGTQPSVSVTEL-KEPDISP 165

Human   164 PETLEPGQPVTVICVFNWAFKKCP--APSFSWTGAALSPRRTRPST--------SHFSVLSFTPS 218
            .:.|..|:.||:.|.   |...||  :|:|:|.| :::..||:..|        |::|.::||||
Frog   166 TKDLIAGEEVTLTCT---APTNCPGLSPTFTWEG-SVNTERTQNHTLRHKDGNFSYWSNITFTPS 226

Human   219 PQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLEVQKGQFL 283
            |:||:|.|||.|.:  |..||:..:.|.|.|.|   :::|:....:     |....|.|::|...
Frog   227 PRDHNTPLTCTVTY--KHESAKANITLNVEYTP---LLNITVPGGT-----GESSSLIVREGDSK 281

Human   284 RLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQQALD 348
            .:.|..:|.|.|.:||...:..:.::...| :.|.|.|:.|...|:..|||.|:|:.||.:.::.
Frog   282 EIYCTVNSNPTANISWTRGNSPVENTKQKG-QNLTLSLQNVTENDTAVYTCTAQNQRGSNKSSVT 345

Human   349 LSVQYPPENLRVMVSQANRTV-LENLGNGTSLPVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGP 412
            :||:|||....:.|.:....: |.|    .|:|  ||.:|.|.|...|:|||.|||.:
Frog   346 VSVEYPPRQPTICVDKPEGCLPLVN----DSVP--EGSTLSLSCRAESNPPANLSWIQ------- 397

Human   413 SQP----SDPGVLELPPIQMEHEGEFTCHAQHPLGSQHVSLSLSVHYPPQLLGPSCSWEAEGLHC 473
            :.|    |:..:|:   :|:.::..:||.|.:..|..:.|:.:.
Frog   398 NDPLKTCSESSILK---VQVTNDIVYTCQATNRYGLSNSSILII--------------------- 438

Human   474 SCSSQASPAPSLRWWLGEELLEGNSSQGSFEVTPSSAGPWANSSLSLHGGLSSGLRLRCKAWNVH 538
                                           |||:.. |..|.       |..||.:
Frog   439 -------------------------------VTPAQK-PQTNL-------LIVGLCI-------- 456

Human   539 GAQSGSVFQLLPGKLEHGGGLGLGAALGAGVAALLAFCSCLVVFRVKICRKEARKRAAAEQDVPS 603
                  :|..|                 |.:||:|.|         :..||:..|:... :::|.
Frog   457 ------LFVTL-----------------AVIAAVLVF---------RWMRKKKNKQEDT-KEMPK 488

Human   604 TLGPISQGHQHECSAGSSQDHPPPGAATYTPGKG------EEQELHYASLSFQGLRLWEPADQEA 662
            :.|.:...:.....:.:::.:.....|.......      :::||.||||.|..|:     .:|.
Frog   489 SDGDVIYNNIENIQSINNESYMDTEKAKRDKDYSNLYMSFDDKELQYASLDFSKLK-----PKED 548

Human   663 PSTTE--YSEIK 672
            |.|.|  ||.:|
Frog   549 PQTEEIIYSVVK 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIGLEC11	NP_443116.2	Ig_Siglec_N	34..153	CDD:143189	37/118 (31%)
		IG_like	39..142	CDD:214653	36/102 (35%)
		IG_like	275..351	CDD:214653	22/75 (29%)
		IGc2	280..341	CDD:197706	18/60 (30%)
		IG_like	378..453	CDD:214653	23/78 (29%)
		Ig	387..450	CDD:143165	19/66 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..635		3/38 (8%)
		ITIM motif	642..647		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..698
siglecl2	NP_001120417.1	Ig	38..156	CDD:386229	37/118 (31%)
		Ig	163..254	CDD:386229	33/96 (34%)
		IG_like	270..348	CDD:214653	22/78 (28%)
		IG	372..439	CDD:214652	23/130 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I35468
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I12170
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1124645at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm54708
Panther	1	1.100	-	-	O	PTHR12035
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X34
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.160