Protein Alignment CHRNB2 and nAChRbeta2

DIOPT Version :9

• Sequence 1: NP_000739.1
• Gene: CHRNB2 / 1141
• HGNCID: 1962
• Length: 502
• Species: Homo sapiens
• Sequence 2: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Alignment Length: 487
• Identity: 212/487 - (43%)
• Similarity: 301/487 - (61%)
• Gaps: 66/487 - (13%)

Human    27 DTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYR 91
            || :||.:.||  |.||:||||..|.:|.:||.|.:.|:|||.|:.:.|:||||:|:.|.|.||:
  Fly    29 DT-KRLYDDLL--SNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYK 90

Human    92 LTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACK 156
            |.|.|||:..::::.:||:|||:||:|||||.||.|||:..:.|.:.|.|.:||.|||||||:|:
  Fly    91 LRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCE 155

Human   157 IEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEV---------ASLDDFTPSGEWDIVALPGRR 212
            :.|::||:|:|.|.|||.||||:..::||....::         ..|.:|..|.||||:.:|..:
  Fly   156 MNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATK 220

Human   213 NEN--PDD-STYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLL 274
            ||.  ||. ..:.|||:...:|||.||||:|||:|||.:|.|.:||||||||.|||:|||||:|:
  Fly   221 NEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILV 285

Human   275 ALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVF 339
            :||||.||:::|:|||||.|||:||||:|||:||:.|:.|:|||||:|.|||:||.|:|.|:.:|
  Fly   286 SLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLF 350

Human   340 LEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCT---CFVNRASVQGLAG 401
            |..:|.|:.|::.::                         ..|..|..|   .:.|...|:....
  Fly   351 LHFMPKLMMMRRTQY-------------------------TLPDYDDSTPSNGYTNEIDVRDSIS 390

Human   402 AFGAEPAPVAGPGRSGEPCGCGLREAVD------------------GVRFIADHMRSEDDDQSVS 448
            .|.:|...........     |::.:||                  .|||||.|::..|.|..:.
  Fly   391 DFPSEFKDSQDGAYDN-----GMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIV 450

Human   449 EDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQ 480
            ||||:|:||:||.|||:|...|||||:.:..|
  Fly   451 EDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQ 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHRNB2	NP_000739.1	LIC	29..479	CDD:273305	209/482 (43%)
		LGIC_ECD_nAChR_B2	31..234	CDD:349826	98/214 (46%)
		Cys-loop	155..169	CDD:349826	6/13 (46%)
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	211/482 (44%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	101/220 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8639
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820