Protein Alignment CHRNB2 and nAChRalpha2

DIOPT Version :10

• Sequence 1: NP_000739.1
• Gene: CHRNB2 / 1141
• HGNCID: 1962
• Length: 502
• Species: Homo sapiens
• Sequence 2: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Alignment Length: 540
• Identity: 225/540 - (41%)
• Similarity: 320/540 - (59%)
• Gaps: 88/540 - (16%)

Human     3 RRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQL 67
            |.|.|:.|||  .||.||..|......:||.:.||  |.||:||||.:|.::.|.|:|.:.|:||
  Fly    21 RHCKPLCLLL--VLLLLCETVQANPDAKRLYDDLL--SNYNRLIRPVSNNTDTVLVKLGLRLSQL 81

Human    68 ISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFY 132
            |.::.::||:||||||..||:|::..|.|.|:..:.::.:||:||||||:||||||||.|.|:..
  Fly    82 IDLNLKDQILTTNVWLEHEWQDHKFKWDPSEYGGVTELYVPSEHIWLPDIVLYNNADGEYVVTTM 146

Human   133 SNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLV---------LK 188
            :.|::.|.|.:.|.||||:||:|:|:|::||||||.|.|||.|||||..:|||.         .|
  Fly   147 TKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNK 211

Human   189 SEVA-SLDDFTPSGEWDIVALPGRRNE-------NPDDSTYVDITYDFIIRRKPLFYTINLIIPC 245
            .|:. .|.::.||.||||:.:|..|:|       .|    |.||.::..:|||.||||:||||||
  Fly   212 VEIGIDLREYYPSVEWDILGVPAERHEKYYPCCAEP----YPDIFFNITLRRKTLFYTVNLIIPC 272

Human   246 VLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTF 310
            |.|:.|::||||||:|.|||:.||||:||:.|:|.||||:|:|.|||.:||:||||:|||:||..
  Fly   273 VGISYLSVLVFYLPADSGEKIALCISILLSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGL 337

Human   311 SIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPR---HHCARQRLRL--------- 363
            |:|.::.:||:|:|.|:||.|.||::..|:::||.||.|:.|:   ...|..::..
  Fly   338 SVVITIIILNIHYRKPSTHKMRPWIRSFFIKRLPKLLLMRVPKDLLRDLAANKINYGLKFSKTKF 402

Human   364 -------------------RRRQREREGAGALFFREAPGADS--CTCFVNRASVQGLAGAFGAEP 407
                               .||.:.|.|||        |.:.  .|...||.|  ||.||.|...
  Fly   403 GQALMDEMQMNSGGSSPDSLRRMQGRVGAG--------GCNGMHVTTATNRFS--GLVGALGGGL 457

Human   408 APVAGPGRSGEPCGCG------------------LREAVDGVRFIADHMRSEDDDQSVSEDWKYV 454
            :.::  |.:|.|....                  |.:|:..|.||..||:.:|:..:..:||.:|
  Fly   458 STLS--GYNGLPSVLSGLDDSLSDVAARKKYPFELEKAIHNVMFIQHHMQRQDEFNAEDQDWGFV 520

Human   455 AMVIDRLFLWIFVFVCVFGT 474
            |||:||||||:|:...:.||
  Fly   521 AMVMDRLFLWLFMIASLVGT 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHRNB2	NP_000739.1	LIC	29..479	CDD:455710	214/514 (42%)
		LGIC_ECD_nAChR_B2	31..234	CDD:349826	100/219 (46%)
		Cys-loop	155..169	CDD:349826	9/13 (69%)
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	101/224 (45%)
		LIC	47..544	CDD:455710	214/512 (42%)
		Cys-loop	169..183	CDD:349832	9/13 (69%)