Protein Alignment CHRNB2 and nAChRalpha1

DIOPT Version :9

• Sequence 1: NP_000739.1
• Gene: CHRNB2 / 1141
• HGNCID: 1962
• Length: 502
• Species: Homo sapiens
• Sequence 2: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Alignment Length: 534
• Identity: 233/534 - (43%)
• Similarity: 322/534 - (60%)
• Gaps: 61/534 - (11%)

Human     6 GPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISV 70
            |.|.....|..|...:|.......:||.:.||  |.||:||||..|.|:.:||::.:.|:|||.|
  Fly     2 GSVLFAAVFIALHFATGGLANPDAKRLYDDLL--SNYNRLIRPVGNNSDRLTVKMGLRLSQLIDV 64

Human    71 HEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNA 135
            :.:.||||||||:.|||.||:|.|.|:::..:..:.:||:||||||:||||||||.|||:..:.|
  Fly    65 NLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKA 129

Human   136 VVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVA-------- 192
            ::.:.|.:.|.|||||||.|:|:|::||||:|.|.|||.|||||...:||....:.|
  Fly   130 ILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVG 194

Human   193 -SLDDFTPSGEWDIVALPGRRNE---NPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAI 253
             .|.|:..|.||||:.:|..|||   :..:..|:||.::..:|||.||||:|||||||.|:.|::
  Fly   195 IDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSV 259

Human   254 LVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCV 318
            ||||||||.|||::||||:||:||||.||:::|:|||||.|||:||||:|||:|||.|:|.::.|
  Fly   260 LVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAV 324

Human   319 LNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPR----------------HHCARQRLRLRRRQ 367
            |||:.|||.||.|||||:.:|::.||.||.:::|:                :|......:.....
  Fly   325 LNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYD 389

Human   368 RER----EGAGAL-----FFREAPGADSCTCFV---------------NRASVQGLAGAFGAEPA 408
            .:|    .|..||     |...|.|..|..||.               :..|..||.|.......
  Fly   390 SKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCC 454

Human   409 PVAGPGRSGE-------PCGCGLREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIF 466
            |.|....:.:       |....:.:.::|.||||.|::::|..:||.|||||||||:||:|||||
  Fly   455 PAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIF 519

Human   467 VFVCVFGTIGMFLQ 480
            ...||.||..:.||
  Fly   520 AIACVVGTALIILQ 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHRNB2	NP_000739.1	LIC	29..479	CDD:273305	226/508 (44%)
		LGIC_ECD_nAChR_B2	31..234	CDD:349826	101/214 (47%)
		Cys-loop	155..169	CDD:349826	8/13 (62%)
nAChRalpha1	NP_001262916.1	Neur_chan_LBD	25..240	CDD:280998	101/216 (47%)
		LIC	27..530	CDD:273305	226/504 (45%)
		Neur_chan_memb	247..530	CDD:280999	119/282 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H595
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8639
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820