Protein Alignment CHRNB2 and nAChRalpha5

DIOPT Version :10

• Sequence 1: NP_000739.1
• Gene: CHRNB2 / 1141
• HGNCID: 1962
• Length: 502
• Species: Homo sapiens
• Sequence 2: NP_001356885.1
• Gene: nAChRalpha5 / 34826
• FlyBaseID: FBgn0028875
• Length: 837
• Species: Drosophila melanogaster
• Alignment Length: 507
• Identity: 188/507 - (37%)
• Similarity: 276/507 - (54%)
• Gaps: 75/507 - (14%)

Human    29 EERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLT 93
            |:||:..||||  ||.|.||..|.|:.:.:...::|.|:|.|.|:.|::.|||||..||.|..|.
  Fly   313 EKRLLHDLLDP--YNTLERPVLNESDPLQLSFGLTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLR 375

Human    94 WKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIE 158
            |...::..:|.:|:|...||.|||::||:||..::.::.:|.||..:||..::||.|:||.|||:
  Fly   376 WNTSDYGGVKDLRIPPHRIWKPDVLMYNSADEGFDGTYQTNVVVRNNGSCLYVPPGIFKSTCKID 440

Human   159 VKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEV-ASLDDFTPSGEWDIVALPGRRNE---NPDDS 219
            :..||||.|.|.|||.|||||..::||.|:.|. ..:..:..:|||:::.:||:|||   |....
  Fly   441 ITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDETGGDISSYVLNGEWELLGVPGKRNEIYYNCCPE 505

Human   220 TYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLIS 284
            .|:|||:..||||:.|:|..|||||||||.|:|:|.|.||.|.|||::|.:::||:|||||.:::
  Fly   506 PYIDITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVA 570

Human   285 KIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFM 349
            :.:|.||..|||:|.|....|.:|..|:|:::.:||.|||:..||.|:.|:::|||..||.:|.|
  Fly   571 ETMPATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADTHEMSEWIRIVFLCWLPWILRM 635

Human   350 QQP-------------------RHHCARQRLRLRRRQ-------------------REREGAGAL 376
            .:|                   |.|.....:.|:.|.                   |.....|.|
  Fly   636 SRPGRPLILEFPTTPCSDTSSERKHQILSDVELKERSSKSLLANVLDIDDDFRHNCRPMTPGGTL 700

Human   377 -----FFREAPGADSCTCFVNRASVQGLAGAFGAEPAPVAGPGRSGEPC---------GCGLREA 427
                 |:|...|...          .|..|..|:...|.|   .:...|         |..|:|
  Fly   701 PHNPAFYRTVYGQGD----------DGSIGPIGSTRMPDA---VTHHTCIKSSTEYELGLILKE- 751

Human   428 VDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFL 479
               :|||.|.:|.:|:...::.|||:.|||:|||.|.||....:..||.:.|
  Fly   752 ---IRFITDQLRKDDECNDIANDWKFAAMVVDRLCLIIFTMFTILATIAVLL 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHRNB2	NP_000739.1	LIC	29..479	CDD:455710	187/505 (37%)
		LGIC_ECD_nAChR_B2	31..234	CDD:349826	89/206 (43%)
		Cys-loop	155..169	CDD:349826	8/13 (62%)
nAChRalpha5	NP_001356885.1	LIC	313..802	CDD:455710	188/507 (37%)