Protein Alignment CHRNB2 and nAChRalpha6

DIOPT Version :10

• Sequence 1: NP_000739.1
• Gene: CHRNB2 / 1141
• HGNCID: 1962
• Length: 502
• Species: Homo sapiens
• Sequence 2: NP_995675.1
• Gene: nAChRalpha6 / 34304
• FlyBaseID: FBgn0032151
• Length: 523
• Species: Drosophila melanogaster
• Alignment Length: 526
• Identity: 198/526 - (37%)
• Similarity: 287/526 - (54%)
• Gaps: 80/526 - (15%)

Human    10 LLLGFGLLR-LCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHER 73
            ||:...::: .|.|    ..|:||:.|||  |.||.|.||..|.||.:.|:..::|.|:|.|.|:
  Fly    14 LLIFLAIIKESCQG----PHEKRLLNHLL--STYNTLERPVANESEPLEVKFGLTLQQIIDVDEK 72

Human    74 EQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVS 138
            .||:|||.||..||.||.|.|...|:..:|.:|:....:|.|||::||:||..::.::::|.||.
  Fly    73 NQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVK 137

Human   139 YDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSE-VASLDDFTPSGE 202
            ::||..::||.|:||.|||::..||||.|:|.|||.|||||..::||||.|| ...|.||..:||
  Fly   138 HNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFITNGE 202

Human   203 WDIVALPGRRNE-----NPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDC 262
            |.::|:||::|.     .|:  .|||||:...|||:.|:|..|||:|||||:|:|:|.|.||.|.
  Fly   203 WYLLAMPGKKNTIVYACCPE--PYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPDS 265

Human   263 GEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLV-----------------------------G 298
            |||:||.:::||:|||||.|:::.:|.||..|||:                             |
  Fly   266 GEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPLLG 330

Human   299 KYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPALLFMQQPRHHCARQRLRL 363
            .|....|.:|..|:|.:|.|||.|||:...|.|.||:|.|||:.||.:|.|.:|.....|:.:.|
  Fly   331 TYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGRKITRKTILL 395

Human   364 RRRQREREGAGALFFREAPGADSCTCFVN--------RASVQGLAGAFGAEPAPVAGPGRSGEP- 419
            ..|.:|.|      .:|   ..|.:...|        |.::.|...|.|:..:       .|.|
  Fly   396 SNRMKELE------LKE---RSSKSLLANVLDIDDDFRHTISGSQTAIGSSAS-------FGRPT 444

Human   420 --------CGCG---LREAVDGVRFIADHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFG 473
                    .||.   |...:..::||...||..||:..:..|||:.|||:||..|.:|....:..
  Fly   445 TVEEHHTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIA 509

Human   474 TIGMFL 479
            |:.:.|
  Fly   510 TVTVLL 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHRNB2	NP_000739.1	LIC	29..479	CDD:455710	193/504 (38%)
		LGIC_ECD_nAChR_B2	31..234	CDD:349826	96/208 (46%)
		Cys-loop	155..169	CDD:349826	8/13 (62%)
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:455710	198/526 (38%)
		LGIC_ECD_nAChR	55..236	CDD:349798	81/182 (45%)
		Cys-loop	154..168	CDD:349798	8/13 (62%)