Protein Alignment CHRNB1 and nAChRbeta1

DIOPT Version :9

• Sequence 1: NP_000738.2
• Gene: CHRNB1 / 1140
• HGNCID: 1961
• Length: 501
• Species: Homo sapiens
• Sequence 2: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 494
• Identity: 198/494 - (40%)
• Similarity: 289/494 - (58%)
• Gaps: 33/494 - (6%)

Human    21 VRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTD 85
            |..||.|.||...||.||:..:||.:.:..:|.|..||...|||::|||::.|.:.|:|.|.|.|
  Fly    22 VSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYD 86

Human    86 YRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYRSS 150
            |:|.||.|::.||..||:..:.||.||:||.||.|||::|....:|::...|.|.|.||.||:||
  Fly    87 YQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSS 151

Human   151 CSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPS 215
            |:|.|||||||.|.|.|.|.|::::..:|||       ...:.:..:....:.::|.|:||..|:
  Fly   152 CTIDVTYFPFDQQTCIMKFGSWTFNGDQVSL-------ALYNNKNFVDLSDYWKSGTWDIIEVPA 209

Human   216 RLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLS 280
            .|....||.....|   .::.||:|||||.|||.||:|.|.:||:.|.:.|||||.:||||:.|.
  Fly   210 YLNVYEGDSNHPTE---TDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLG 271

Human   281 IFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLW 345
            |..||:|.|||||::..:|.|||.:|:|.|||:||.::.|.|::::|:::|.:.|.|.||:||::
  Fly   272 ISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMY 336

Human   346 VRQIFIHKLPLYLRLKRPKPER---------DLMPEPPHCS--SPG------SGWGRGTDEYFIR 393
            :|.||:|.||.:|.:|||:..|         ..||..||.|  ||.      |..| |.......
  Fly   337 IRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIG-GKQSKMEV 400

Human   394 KPPSDFLFP--KPNR---FQPELSAPDLRRFIDGPNRAVALLPELREVVSSISYIARQLQEQEDH 453
            ...||...|  |.||   ...||...|..|.....:.::.|.||..:...::.:||..|:.::.:
  Fly   401 MELSDLHHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLY 465

Human   454 DALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIFLDATY 492
            ...:|||::||||:|||.|:.|.|.|:.||:.|.:||.:
  Fly   466 IQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPH 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHRNB1	NP_000738.2	Neur_chan_LBD	27..245	CDD:308532	88/217 (41%)
		Neur_chan_memb	252..487	CDD:308533	98/256 (38%)
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	196/488 (40%)
		Neur_chan_LBD	28..236	CDD:280998	88/217 (41%)
		Neur_chan_memb	243..498	CDD:280999	98/255 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4377
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.720