DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Gucy2e and Gyc76C

DIOPT Version :9

Sequence 1:NP_570093.2 Gene:Gucy2e / 113911 RGDID:69322 Length:1123 Species:Rattus norvegicus
Sequence 2:NP_001163473.1 Gene:Gyc76C / 8674026 FlyBaseID:FBgn0266136 Length:1525 Species:Drosophila melanogaster


Alignment Length:1169 Identity:360/1169 - (30%)
Similarity:539/1169 - (46%) Gaps:170/1169 - (14%)


- Green bases have known domain annotations that are detailed below.


  Rat    67 RETFTLGVLGPWDCDPIFAQALP-SMATQLAVDRVNQDASLLLGSQLDFKILPTGCDTPHALATF 130
            |...|:|.|.....|....|.|. |.|..:|:|.||:|.:||....||.:...|..||  .|||.
  Fly    23 RTVLTVGYLTALTGDLKTRQGLAISGALTMALDEVNKDPNLLPNVYLDLRWNDTKGDT--VLATK 85

  Rat   131 VAHR---NTVAAFIGPVNPGYCPAAALLAQGWGKSLFSWACGAPEGGGALVPTL----PSMADV- 187
            ....   :.:|...||..|  |...|:::|.....:.|:.|.  |...:.:||.    |....| 
  Fly    86 AITEMICDGIATIFGPEGP--CYVEAIVSQSRNIPMISYKCA--EYRASAIPTFARTEPPDTQVV 146

  Rat   188 --LLSVMRHFGWARLAIVSSHQDIWVTTAQQLATAFRAHGLPIGLITSLGPGEKGATEVCKQL-- 248
              ||:::|::.|.:.:|:  ::|:|...|..|........:.|....|.   .....:.|:|:  
  Fly   147 KSLLALLRYYAWNKFSIL--YEDVWSPVADLLKDQATKRNMTINHKQSF---IDNRVKCCEQMLD 206

  Rat   249 --HSVHGLKIVVLCMHS----ALLGGLEQTV-LLRCARKEGL-TDGRLVFLPYDTLLFA------ 299
              .|.:..::|...|:.    ..||.....| .:......|| ..|..:.:..|.::::      
  Fly   207 CCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEK 271

  Rat   300 -------LPYRN------------RSYLVLDDDGPLQEAYDAVLTISLDTSPESHAFTATKMRGG 345
                   :.:.:            ||.||:....|.::...  .|..:........|.....|..
  Fly   272 YLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTKDYIQ--FTKQVQKYSSKPPFNLEIPRLF 334

  Rat   346 TAANLGPEQVSPLFGTIYDAVILLAHALN----------------HSEAHGTGLSGAHLGNHIRA 394
            ..:|.. :.:|.....:||:|.|.|.|::                ...::||.:....:.|. ..
  Fly   335 VESNFS-KFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNR-TY 397

  Rat   395 LDVAGFSQRIRIDGKGRRLPQYVIL-----DTNGEGSQLVPTHILDVS-------TQQVQPLGTA 447
            :.:.|  .:|:||..|.....:.:|     ..|...:.....|::.|:       ..:.:.:..:
  Fly   398 MSITG--SKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLINGS 460

  Rat   448 VHFP-GGSPPARDASCWFDPNTLCIRGVQPLGSLLTLTITCVLALVGGFLA------YFIRLGLQ 505
            :.:| ||..||.:..|.| .|.||.:......|.:...:..||....|.:.      :.|.|.::
  Fly   461 IDWPSGGEKPADEPMCGF-ANELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIE 524

  Rat   506 QLRLLRGPHRILLTPQELTFLQRTPSRRRPHVDSGSESRSVVDGGSPQSVIQG---STRSVPAFL 567
            .|.....|:.|                      .|.....:|...|..|::..   .:|....|:
  Fly   525 GLLWKIDPNEI----------------------KGYSGNEIVSSPSKVSLMSAQSYGSRWTNQFV 567

  Rat   568 EHTNVALYQGEWVWLKKFEAGTAPDLRPSSLSLLRKMREMRHENVTAFLGLFVGPEVSAMVLEHC 632
              |:....:|..|.:|:.:.....|:....:..:|.:||:||:|:.:|:|..|.|....:|.::|
  Fly   568 --TSTGRLRGAVVRIKELKFPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYC 630

  Rat   633 ARGSLEDLLRNEDLRLDWTFKASLLLDLIRGLRYLHHRHFP-HGRLKSRNCVVDTRFVLKITDHG 696
            |:|||.|::.|||::||..|.|||:.|||:|:.|:|:.... ||.|||.||||.:|::|::||.|
  Fly   631 AKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFG 695

  Rat   697 YAEF--------LESHCSFRPQPAPEELLWTAPELLRGPRRPWGPGKATFKGDVFSLGIILQEVL 753
            ..|.        :..|..:|.|      ||.||||||....      .:.||||::..||:.|:.
  Fly   696 LHELRQCAENESIGEHQHYRNQ------LWRAPELLRNHIH------GSQKGDVYAFAIIMYEIF 748

  Rat   754 TRDPPYCSWGLSAEEIIRKVASPP--------PLCRPLVSPDQGPLECIQLMQLCWEEAPDDRPS 810
            :|..|:.......:||:..|...|        |....::..:..|...:..::.||.|.|::||.
  Fly   749 SRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPE 813

  Rat   811 LDQIYTQFKSINQGKKTSVADSMLRMLEKYSQSLEGLVQERTEELELERRKTERLLSQMLPPSVA 875
            ...|..:.|.:..||..::.|.|:.|:|||:.:||.:|.|||..|..|:.|||.||.:|||.|||
  Fly   814 FSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVA 878

  Rat   876 HALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEVVGFLNDLYTMFDAVLDSHDVYKVETI 940
            ..|.||..|||..:|.||||||||||||.:||.|.|::||.|||||||:||.::..:||||||||
  Fly   879 EKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETI 943

  Rat   941 GDAYMVASGLPRRNGNRHAAEIANMALEILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLT 1005
            ||||||.||||.:||:|||.|||:||||:|......|:.|.|:..:::|.|:|:||.||||||||
  Fly   944 GDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLT 1008

  Rat  1006 MPRYCLFGDTVNTASRMESTGLPYRIHVSRNTVQALLSLDEGYKIDVRGQTELKGKGLEETYWLT 1070
            |||||||||||||||||||.|...:||:|.....||..|..||..:.||...:||||...|:|||
  Fly  1009 MPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLT 1073

  Rat  1071 G--------KTGFCRSLPTPLSIQP-------GDPWQDHINQEIRTGFAKARQSLAEPRSSGDT 1119
            |        |......:|.||..:|       .|..|..|......|....|||.......|::
  Fly  1074 GANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPRAMDGES 1137

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gucy2eNP_570093.2 PBP1_sensory_GC_DEF-like 71..445 CDD:380594 88/447 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 529..556 4/26 (15%)
PK_GC-2D 554..824 CDD:270945 89/289 (31%)
CYCc 861..1050 CDD:214485 120/188 (64%)
Interaction with NCALD. /evidence=ECO:0000269|PubMed:18178149 880..921 27/40 (68%)
Gyc76CNP_001163473.1 PBP1_Speract_GC_like 26..445 CDD:107365 88/435 (20%)
ANF_receptor 48..412 CDD:279440 76/380 (20%)
PK_GC-A_B 543..827 CDD:270944 91/297 (31%)
HNOBA <835..881 CDD:285003 24/45 (53%)
CYCc 860..1052 CDD:214485 120/191 (63%)
Guanylate_cyc 887..1074 CDD:278633 115/186 (62%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.