Protein Alignment CHRNA5 and nAChRbeta1

DIOPT Version :10

• Sequence 1: NP_000736.2
• Gene: CHRNA5 / 1138
• HGNCID: 1959
• Length: 468
• Species: Homo sapiens
• Sequence 2: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 499
• Identity: 186/499 - (37%)
• Similarity: 280/499 - (56%)
• Gaps: 95/499 - (19%)

Human    42 SIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDV 106
            |.::.|:.|::|||:.|.:.:|||:::..|:.::||||..||::|:||||:|.:||||:..|.|.
  Fly    23 SASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDY 87

Human   107 KLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRY-NGTVTWTPPANYKSSC 170
            :|:|:..|||||.|:|:|.|.||.||||||:||||.:|......|:.| .|.|.|.|||.|:|||
  Fly    88 QLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSC 152

Human   171 TIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQD--VDKRDFFDNGEWEIVSA-------TGS 226
            |||||:||||.|.|.|||||||::|.||.:.|.:..  ||..|::.:|.|:|:..       .|.
  Fly   153 TIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLNVYEGD 217

Human   227 KGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVS 291
            ..:.|::     .:|:..:|:|..||||:.||:|.:.:|||.|||||||:..|||:.|..|:|:|
  Fly   218 SNHPTET-----DITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEAGEKVTLGISILLS 277

Human   292 LTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIF 356
            |.||||::.:|:|.:|.|:|||.:||:||.|..|:||:|||..||.:.|...||. |...:|.||
  Fly   278 LVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHR-MPMYIRSIF 341

Human   357 LHTLPKLLCMR-------------------SH--------------------------------- 369
            ||.||..|.|:                   :|
  Fly   342 LHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGGKQSKMEVMELSDL 406

Human   370 ------VDRYFTQKEETESGSG--------------PKSSRNTLEAALDSIRYITRHIMKENDVR 414
                  ::|......|...|.|              |::|:     |.:::.:|..|:..|:...
  Fly   407 HHPNCKINRKVNSGGELGLGDGCRRESESSDSILLSPEASK-----ATEAVEFIAEHLRNEDLYI 466

Human   415 EVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFV--PVIYKWAN 456
            :..||||::|.|:||:.|:.|..|:..|::|:.:  |.|:::.:
  Fly   467 QTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFEYVD 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHRNA5	NP_000736.2	LGIC_ECD_nAChR_A5	45..251	CDD:349819	97/215 (45%)
		Cys-loop	170..184	CDD:349819	11/13 (85%)
		Neur_chan_memb	257..447	CDD:460753	82/261 (31%)
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	184/487 (38%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	97/213 (46%)
		Cys-loop	152..166	CDD:349833	11/13 (85%)