DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHRNA4 and nAChRalpha6

DIOPT Version :9

Sequence 1:	NP_000735.1	Gene:	CHRNA4 / 1137	HGNCID:	1958	Length:	627	Species:	Homo sapiens
Sequence 2:	NP_995675.1	Gene:	nAChRalpha6 / 34304	FlyBaseID:	FBgn0032151	Length:	523	Species:	Drosophila melanogaster

Alignment Length:	641	Identity:	206/641 - (32%)
Similarity:	296/641 - (46%)	Gaps:	161/641 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     9 PRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQL 73
            |..|...:||:...:::.|    .:...|:|||..|.|.||...|||||.|:.:.|:|||::.|:
  Fly     6 PASLSLFVLLIFLAIIKES----CQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQI 66

Human    74 IDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHL 138
            ||||||||::|||.|:..||:||.|||:..:|..|..:||....:|:||:::||:||..|..|:.
  Fly    67 IDVDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYH 131

Human   139 TKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLV-NMHSRVDQLD 202
            |...:.|:|...:.||.|:||:|.||:|:||||.|:|.|||||||||..::||| |.....|..|
  Fly   132 TNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSD 196

Human   203 FWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYL 267
            |..:|||.::...|..||..|.||.|.|.|||:...|||..|:|..|||:||:|||.:.:|.|.|
  Fly   197 FITNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTL 261

Human   268 PSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFT------------------- 313
            |.:.|||:||.:::||||||||.|:.|.:|:||..:||||..:|.:
  Fly   262 PPDSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAI 326

Human   314 ----------MIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNC 368
                      |..|..|:|:||.|||.|||:...|.||.|::.|||..:|.:|.|.||.  :...
  Fly   327 PLLGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPG--RKIT 389

Human   369 RRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQ 433
            |:.|...::|                                                      :
  Fly   390 RKTILLSNRM------------------------------------------------------K 400

Human   434 PLEAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQYCVPRDDA 498
            .||.::.|                     ::||....:...                     ||.
  Fly   401 ELELKERS---------------------SKSLLANVLDID---------------------DDF 423

Human   499 APEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPA 563
            .....|... |:.|    ||....|                    .||:...|.....|..|...
  Fly   424 RHTISGSQT-AIGS----SASFGRP--------------------TTVEEHHTAIGCNHKDLHLI 463

Human   564 LTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL 619
            |    :.:|:|...::..|.:..:..|||:.|||:||..|.:|.:..::.||.:.|
  Fly   464 L----KELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLL 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHRNA4	NP_000735.1	Neur_chan_LBD	37..243	CDD:280998	102/206 (50%)
		Neur_chan_memb	250..618	CDD:280999	95/396 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..481		5/98 (5%)
		Ten_N	<423..>572	CDD:284015	19/148 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..561		12/64 (19%)
nAChRalpha6	NP_995675.1	LIC	11..517	CDD:273305	204/636 (32%)
nAChRalpha6	NP_995675.1	LGIC_ECD_nAChR	55..236	CDD:349798	87/180 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910