DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CHRNA3 and nAChRalpha6

DIOPT Version :9

Sequence 1:NP_000734.2 Gene:CHRNA3 / 1136 HGNCID:1957 Length:505 Species:Homo sapiens
Sequence 2:NP_995675.1 Gene:nAChRalpha6 / 34304 FlyBaseID:FBgn0032151 Length:523 Species:Drosophila melanogaster


Alignment Length:518 Identity:193/518 - (37%)
Similarity:290/518 - (55%) Gaps:36/518 - (6%)


- Green bases have known domain annotations that are detailed below.


Human     9 PLALSPPRLLLLLLLSLLPVARASEAEHRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVK 73
            ||..|....:||:.|:::..:.....|.||...|...||.:.|||||.|:|:.:.|.:::.|::.
  Fly     4 PLPASLSLFVLLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIID 68

Human    74 VDEVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTK 138
            |||.|||:.||.||...||||.|:||.::|||.:.:|:...|:||||:::||:|...|.....|.
  Fly    69 VDEKNQILTTNAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTN 133

Human   139 ALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIG-SSMNLKDYW 202
            .::|:.|...::||.||||:||||:|:||||.|:|.||||||:||..::||||.. ...:|.|:.
  Fly   134 IVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGGDLSDFI 198

Human   203 ESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPS 267
            .:|||.::..||.|:.|.|.||.|.|.|||:::.|||..|:|..|||:||:|||.:.:|.|.||.
  Fly   199 TNGEWYLLAMPGKKNTIVYACCPEPYVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPP 263

Human   268 DCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFT--------------------- 311
            |.|||:||.:::||||||||.::.|::|:||..:||||..:|.:                     
  Fly   264 DSGEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPL 328

Human   312 --------MIFVTLSIVITVFVLNVHYRTPTTHTMPSWVKTVFLNLLPRVMFMTRPTSNEGNAQK 368
                    |..|..|:|:||.|||.|:||...|.||.|:|:|||..||.::.|.||..   ...:
  Fly   329 LGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWILRMGRPGR---KITR 390

Human   369 PRPLYGAELSNLNCFSRAESKGCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLS 433
            ...|....:..|....|:............|.........:..|.: ||:..|.::.|.....:.
  Fly   391 KTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGS-SASFGRPTTVEEHHTAIG 454

Human   434 LSALSPEIKEAIQSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFL 496
            .:  ..::...::.:::|...|:..::..|:..|||:.|||:||..|.||||..|:.|..:.|
  Fly   455 CN--HKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLL 515

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CHRNA3NP_000734.2 Neur_chan_LBD 30..496 CDD:332142 186/495 (38%)
nAChRalpha6NP_995675.1 LIC 11..517 CDD:273305 190/511 (37%)
LGIC_ECD_nAChR 55..236 CDD:349798 83/180 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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