DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF13 and IRC20

DIOPT Version :9

Sequence 1:	NP_001365214.1	Gene:	RNF13 / 11342	HGNCID:	10057	Length:	381	Species:	Homo sapiens
Sequence 2:	NP_013348.1	Gene:	IRC20 / 850949	SGDID:	S000004237	Length:	1556	Species:	Saccharomyces cerevisiae

Alignment Length:	117	Identity:	34/117 - (29%)
Similarity:	49/117 - (41%)	Gaps:	31/117 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   240 CAICLDEYEDGDKLRILPCSHAYHCK-CVDPWLTKTKKTCPVCK--------------------Q 283
            |:|||.|.|.|   .|:.|.| |.|| |:..||....| ||:||                    :
Yeast  1239 CSICLGEVEIG---AIIKCGH-YFCKSCILTWLRAHSK-CPICKGFCSISEVYNFKFKNSTEKRE 1298

Human   284 KVV--PSQGDSDSDTDSSQEENEVTEHTPLLRPLASVSAQSFGALSESRSHQ 333
            |.:  |.:..:||..|:| .||.:..:...:..|.....:.|..::|  .||
Yeast  1299 KEIQEPRREGADSSQDNS-NENSIISNMSEVEKLFGNKYEQFHQINE--VHQ 1347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF13	NP_001365214.1	PA_C_RZF_like	23..180	CDD:239038
		RING-H2_RNF167	238..283	CDD:319711	21/63 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..381		12/51 (24%)
IRC20	NP_013348.1	HepA	172..>568	CDD:223627
		DEXQc_SHPRH	383..602	CDD:350828
		RAD18	1234..>1327	CDD:227719	29/93 (31%)
		RING-HC_RNF10	1239..1276	CDD:319450	19/41 (46%)
		SF2_C_SNF	1356..1485	CDD:350180
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910