DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF13 and rnf13

DIOPT Version :9

Sequence 1:	NP_001365214.1	Gene:	RNF13 / 11342	HGNCID:	10057	Length:	381	Species:	Homo sapiens
Sequence 2:	NP_957338.1	Gene:	rnf13 / 793981	ZFINID:	ZDB-GENE-040426-772	Length:	377	Species:	Danio rerio

Alignment Length:	382	Identity:	290/382 - (75%)
Similarity:	334/382 - (87%)	Gaps:	9/382 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLK 65
            ||||:|||||||||:|||.|||:|||||||||||||.||:|:|.::.|||||||||||||:||||
Zfish     1 MLLSLGMLMLSATQIYTIFTVQIFAFLNLLPVEADISAYSFDNKTENFDDLPARFGYRLPSEGLK 65

Human    66 GFLINSKPENACEPIVPPPVKDNSSGTFIVLIRRLDCNFDIKVLNAQRAGYKAAIVHNVDSDDLI 130
            ||||.::|||||.||.|||.::|.|..|||||||.|||||||||:||:|||||||||||||||||
Zfish    66 GFLIGARPENACVPIEPPPQRENLSSAFIVLIRRFDCNFDIKVLHAQKAGYKAAIVHNVDSDDLI 130

Human   131 SMGSNDIEVLKKIDIPSVFIGESSANSLKDEFTYEKGGHLILVPEFSLPLEYYLIPFLIIVGICL 195
            ||||.|:::||:||||||||||.:|||||:::.||||||:||:|:||||||||||||||||||||
Zfish   131 SMGSEDLDILKQIDIPSVFIGEEAANSLKEDYIYEKGGHVILMPDFSLPLEYYLIPFLIIVGICL 195

Human   196 ILIVIFMITKFVQDRHRARRNRLRKDQLKKLPVHKFKKGDEYDVCAICLDEYEDGDKLRILPCSH 260
            ||||:|||||||||||||||:|||||||||||:|||||||.||||||||||||:|::||:|||||
Zfish   196 ILIVVFMITKFVQDRHRARRSRLRKDQLKKLPIHKFKKGDSYDVCAICLDEYEEGERLRVLPCSH 260

Human   261 AYHCKCVDPWLTKTKKTCPVCKQKVVPSQGDSDSDT---DSSQEENEVTEHTPLLRPLASVSAQS 322
            ||||||||||||||||||||||||||||.|||:||:   ||..|:|||:|:|||||.|||.||.|
Zfish   261 AYHCKCVDPWLTKTKKTCPVCKQKVVPSDGDSESDSDSVDSGGEDNEVSENTPLLRSLASTSAHS 325

Human   323 FGALSESRSHQNMTESSDYEEDDNEDTDSSDAENEINEHDVVVQLQPNGERDYNIAN 379
            ||::|.|.| |:...||||:    |.:||||:|.|:....|||||| .|..|...||
Zfish   326 FGSMSASLS-QHDAGSSDYD----ERSDSSDSEEEVTVETVVVQLQ-QGRPDDTEAN 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF13	NP_001365214.1	PA_C_RZF_like	23..180	CDD:239038	119/156 (76%)
		RING-H2_RNF167	238..283	CDD:319711	40/44 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..381		54/98 (55%)
rnf13	NP_957338.1	PA_C_RZF_like	23..180	CDD:239038	119/156 (76%)
rnf13	NP_957338.1	zf-RING_2	238..282	CDD:290367	39/43 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194342924
Domainoid	1	1.000	151	1.000	Domainoid score	I17715
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13493
Inparanoid	1	1.050	588	1.000	Inparanoid score	I5423
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG51404
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0001489
OrthoInspector	1	1.000	-	-		oto51244
orthoMCL	1	0.900	-	-		OOG6_103040
Panther	1	1.100	-	-	LDO	PTHR22765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1776
SonicParanoid	1	1.000	-	-		X670
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	17	17.440