Protein Alignment EXOSC8 and Rrp45

DIOPT Version :10

• Sequence 1: NP_852480.1
• Gene: EXOSC8 / 11340
• HGNCID: 17035
• Length: 276
• Species: Homo sapiens
• Sequence 2: NP_573163.1
• Gene: Rrp45 / 32665
• FlyBaseID: FBgn0030789
• Length: 412
• Species: Drosophila melanogaster
• Alignment Length: 269
• Identity: 75/269 - (27%)
• Similarity: 129/269 - (47%)
• Gaps: 23/269 - (8%)

Human    18 LKENCRPDGRELGEFRTTTVNIGSISTAD-GSALVKLGNTTVICGVKAEFAAPSTDAPDKGYVVP 81
            :|:|.|.|||...|.|...:..|.    | ||..|.:|:|.|:..|..|...|:...|::|.:..
  Fly    24 VKQNQRLDGRRSNESRDVELTFGK----DWGSVAVSMGDTKVLAQVTCEMGPPALSRPNEGKIHL 84

Human    82 NVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENSQIIQKEDLCISPGKLVWVLYCDLICLDYDG 146
            ||.|..:...........:.:...:..:.....:|:.|..|.||::..|.||.:..::..|::||
  Fly    85 NVYLGGVAFLDEAHTTHDQRSLKLNSLLERTFRSSRSIDLESLCVAVEKHVWCIRVNVNVLNHDG 149

Human   147 NILDACTFALLAALKNVQLPEVTINEETALAEVNL---KKKSYLNIRTH--PVATSFAVFDDTLL 206
            |:.||.|.|.||||.:.:.|:|...:    .|:.:   |::.::.:..|  ||:.::.|:..::.
  Fly   150 NLYDASTIATLAALMHFRRPDVWYKD----GELRIFKKKEREFIPLLFHHYPVSVTYCVYKSSVQ 210

Human   207 -IVDPTGEEEHLATGTLTIVMDEEGKLCCLHKPGGSGLTGAK-LQDCMSRAVTRHKE----VKK- 264
             |:|||..||:.|...:.:..:...:||.| ..||:..|.|: :..|...|..|.|.    |:|
  Fly   211 PILDPTLLEENAADSVIVLSFNSFQELCSL-TAGGTAPTNARIIMQCARNAAVRCKSLLNFVRKA 274

Human   265 -LMDEVIKS 272
             .:||..:|
  Fly   275 LALDEECRS 283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EXOSC8	NP_852480.1	RNase_PH_RRP43	6..266	CDD:206774	72/261 (28%)
Rrp45	NP_573163.1	RNase_PH_RRP45	13..268	CDD:206773	70/252 (28%)