Protein Alignment CHRNA1 and nAChRbeta1

DIOPT Version :9

• Sequence 1: XP_016858745.1
• Gene: CHRNA1 / 1134
• HGNCID: 1955
• Length: 489
• Species: Homo sapiens
• Sequence 2: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 552
• Identity: 192/552 - (34%)
• Similarity: 292/552 - (52%)
• Gaps: 125/552 - (22%)

Human    13 TVLVSSAVSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIV 77
            ::||..|.|  ||..||.|.|||..||:.|:.::|||::..|.|.|..||..:|||||:|.|||:
  Fly    12 SILVLVAFS--LVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIM 74

Human    78 TTNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDL 142
            .:||.|:   :|                      |.||.|:|:..||||:..:.:|.:|:|:||:
  Fly    75 KSNVWLR---LV----------------------WYDYQLQWDEADYGGIGVLRLPPDKVWKPDI 114

Human   143 VLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSV 207
            ||:|||||::.:...:.||:..||.:.|.||||::|.|.|.||:||||:|.|.||.|:||::|..
  Fly   115 VLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQ 179

Human   208 V--AINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTP-YLDITYHFVMQRLPLYFIVN 269
            |  |:....:..|||::.:||.|.|.|...:.:  .|....:.| ..|||::.:::|..|::.||
  Fly   180 VSLALYNNKNFVDLSDYWKSGTWDIIEVPAYLN--VYEGDSNHPTETDITFYIIIRRKTLFYTVN 242

Human   270 VIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTM 334
            :|:|.:|.|||..||||||.::|||:||.||:||||.||||::.:::|.||..:|||.||:|||.
  Fly   243 LILPTVLISFLCVLVFYLPAEAGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTF 307

Human   335 VFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSRE------------ 387
            :....||::|||:||.:.|.|.||.||.::|.:|:..:|..:|   ||||.:.
  Fly   308 IMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIFLHYLPAFLF---MKRPRKTRLRWMMEMPGMS 369

Human   388 ------------------------KQDKKIFTEDIDISDISGKPGPPPMGFHSP----------- 417
                                    ||.|   .|.:::||:           |.|
  Fly   370 MPAHPHPSYGSPAELPKHISAIGGKQSK---MEVMELSDL-----------HHPNCKINRKVNSG 420

Human   418 ------------------LIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLG 464
                              ::..||...|.|.:::|||.::::........:|||||||:|.:.|.
  Fly   421 GELGLGDGCRRESESSDSILLSPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLY 485

Human   465 VFMLVCIIGTLAVF-----------AGRLIEL 485
            :|.:|...||:.:.           ..|:||:
  Fly   486 IFFIVTTAGTVGILMDAPHIFEYVDQDRIIEI 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHRNA1	XP_016858745.1	None
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	189/533 (35%)
		Neur_chan_LBD	28..236	CDD:280998	91/234 (39%)
		Neur_chan_memb	243..498	CDD:280999	87/271 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.880