Protein Alignment U2AF2 and MUD2

DIOPT Version :10

• Sequence 1: NP_009210.1
• Gene: U2AF2 / 11338
• HGNCID: 23156
• Length: 475
• Species: Homo sapiens
• Sequence 2: NP_012849.1
• Gene: MUD2 / 853788
• SGDID: S000001557
• Length: 527
• Species: Saccharomyces cerevisiae
• Alignment Length: 569
• Identity: 125/569 - (21%)
• Similarity: 200/569 - (35%)
• Gaps: 200/569 - (35%)

Human     7 FERQLNENKQERDKENRHRKRSHSRSRS--------------------------RDRKRRSRSRD 45
            |:||.::.  |..|..:.|..|||.:|.                          ||...||.:|:
Yeast    44 FKRQKSDG--ELPKAPKSRNVSHSNNRGPSSIITMSTNRTTYEQTRAGPHRQSYRDASGRSYNRE 106

Human    46 RR----------NRDQRSASRDRRR-RSKPLTRGAKEEHGGLIR-------------SPRHEKKK 86
            .|          |.:..:..||.|| |::...|..:..:|...|             ..|.:::.
Yeast   107 NRYSSHNTGPQWNNNPYNRQRDERRGRNERFDRRGRNGNGNYDRFNYQRKNEGSKFNGDRDKRQL 171

Human    87 KVRKY------WDVPPPGFEHITPMQYK--AMQAAGQIPATALLPTMTPDGLAVTPTPVPVVGSQ 143
            :..||      .:|..||....:|..|.  :.:|..::..:.|..:..|..:|
Yeast   172 QTNKYDMNYNSQNVMYPGSSFDSPAYYNMASSKANSRLVISGLSQSSDPSIVA------------ 224

Human   144 MTRQARRL--YVGNIPFGI--TEEAMMDFFNAQMRLGGLTQAPGNPVLAVQINQDKNFAFLEFRS 204
                  ||  .:.|...|:  ||....||..:...:|     .|.|          :...:||.|
Yeast   225 ------RLKDLLENFISGLQKTESNAEDFKISNFYIG-----EGRP----------DHIIVEFSS 268

Human   205 VDETTQAMA-----------FDGIIFQGQSLKIRRPHDY-QPLPGMSENPSVYVPGVVSTVVPDS 257
            ...:|..:|           ||        ||.|||:|| |.|..:.:    :..|   ||:
Yeast   269 QICSTMVLACRSFFNAKLGTFD--------LKWRRPNDYVQQLDHLVD----FCRG---TVI--- 315

Human   258 AHKLFIGGLPNYLN-----DDQVKELLTSFGPLKAFNLVKDSA-------------TGLSKGYAF 304
                   .|.|..|     |.::|||.:|      .|:...:|             ||....:..
Yeast   316 -------ALENLENIGEGEDYRMKELFSS------LNVTNGTAKPLFYKCSSNTNNTGKESEFTK 367

Human   305 CEYVDINVTDQAIAGLNGMQLGDKKLLVQRASVGAKNATLVSP-PSTINQTP--VTLQ-VPGLMS 365
            |..:...|..|.|.        ||          .|......| ...|:|..  :|.| :|.|::
Yeast   368 CILLSFEVVTQDIL--------DK----------LKPYKWFKPNDGKISQVTSWITFQSLPNLVT 414

Human   366 SQVQMGGHPTEVLCLMNMVLPEELLDDEEYEEIVEDVRDECSKYGL--VKSIEIPRPVDGVE--- 425
            ..|::   .:.||.|:|.:.|.:|.|:....||.|.:     ||.:  ..:|:|.:|  ||:
Yeast   415 QSVRV---ESRVLLLLNCLDPLDLKDETFITEIKETL-----KYSIAGADTIKICQP--GVDYRL 469

Human   426 -----VPGCGKIFVEFTSVFDCQKAMQGLTGRKFANRVVVTKYCDPDSY 469
                 ..|.|.|:::|.::...:.||:.|.|.:|.:|.|:..|.|.|.:
Yeast   470 NFENLASGAGNIYIKFKTLEAAKHAMEELPGTQFNDRTVLCTYIDEDDF 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
U2AF2	NP_009210.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..90		26/132 (20%)
		Required for interaction with PRPF19. /evidence=ECO:0000269|PubMed:21536736	2..93		28/141 (20%)
		Necessary and sufficient to stimulate pre-mRNAs 3'-end cleavage in a CFIm complex-dependent manner. /evidence=ECO:0000269|PubMed:17024186	17..47		12/55 (22%)
		U2AF_lg	63..474	CDD:273727	103/476 (22%)
MUD2	NP_012849.1	PRK12678	<46..>156	CDD:237171	24/111 (22%)
		RRM_1	436..511	CDD:214637	22/81 (27%)