DRSC/TRiP Functional Genomics Resources

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Protein Alignment U2AF2 and u2af2a

DIOPT Version :10

Sequence 1:NP_009210.1 Gene:U2AF2 / 11338 HGNCID:23156 Length:475 Species:Homo sapiens
Sequence 2:XP_005157952.1 Gene:u2af2a / 557103 ZFINID:ZDB-GENE-050706-131 Length:470 Species:Danio rerio


Alignment Length:488 Identity:416/488 - (85%)
Similarity:434/488 - (88%) Gaps:31/488 - (6%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSDFDEFERQLNENKQ-ERDKENRHRKRSHSRSRS--RDRKRRSRSRDRR---NRDQRSASRDRR 59
            |||||||||||.|||| :|||||:|.:||.|||||  ||||||||.|||.   :||:...|:|||
Zfish     1 MSDFDEFERQLTENKQADRDKENKHHRRSGSRSRSRDRDRKRRSRDRDRERRGSRDRHGDSKDRR 65

Human    60 RRSKPLTRGAKEEHGGLIRSPRHEKKK-KVRKYWDVPPPGFEHITPMQYKAMQAAGQIPATALLP 123
            .|..              |||..|||| ||:||||||||||||||||||||||||||||||||||
Zfish    66 HRRS--------------RSPHREKKKIKVKKYWDVPPPGFEHITPMQYKAMQAAGQIPATALLP 116

Human   124 TMTPDGLAVTPTPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLA 188
            ||||:|||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||
Zfish   117 TMTPEGLAVTPTPVPVVGSQMTRQARRLYVGNIPFGITEESMMDFFNAQMRLGGLTQAPGNPVLA 181

Human   189 VQINQDKNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSENPSVYVP-----G 248
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||     |
Zfish   182 VQINQDKNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSENPSVYVPGSLPVG 246

Human   249 VVSTVVPDSAHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVT 313
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|::
Zfish   247 VVSTVVPDSAHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDVNIS 311

Human   314 DQAIAGLNGMQLGDKKLLVQRASVGAKNATLVSPPSTINQTPVTLQVPGLMSSQV-QMGGHPTEV 377
            |||||||||||||||||||||||||:||.||..    ||||||||||||||:|.| ||||.||||
Zfish   312 DQAIAGLNGMQLGDKKLLVQRASVGSKNTTLTG----INQTPVTLQVPGLMNSSVNQMGGIPTEV 372

Human   378 LCLMNMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGVEVPGCGKIFVEFTSVFDC 442
            |||||||.|||||||||||||||||||||||||.||||||||||||:::||.|||||||.||||.
Zfish   373 LCLMNMVAPEELLDDEEYEEIVEDVRDECSKYGQVKSIEIPRPVDGLDIPGTGKIFVEFMSVFDS 437

Human   443 QKAMQGLTGRKFANRVVVTKYCDPDSYHRRDFW 475
            |||||||||||||||||||||||||:|||||||
Zfish   438 QKAMQGLTGRKFANRVVVTKYCDPDAYHRRDFW 470

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
U2AF2NP_009210.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..90 55/95 (58%)
Required for interaction with PRPF19. /evidence=ECO:0000269|PubMed:21536736 2..93 56/97 (58%)
Necessary and sufficient to stimulate pre-mRNAs 3'-end cleavage in a CFIm complex-dependent manner. /evidence=ECO:0000269|PubMed:17024186 17..47 23/31 (74%)
U2AF_lg 63..474 CDD:273727 367/417 (88%)
u2af2aXP_005157952.1 U2AF_lg <84..469 CDD:273727 357/388 (92%)

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