DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment U2AF2 and u2af2

DIOPT Version :9

Sequence 1:	NP_009210.1	Gene:	U2AF2 / 11338	HGNCID:	23156	Length:	475	Species:	Homo sapiens
Sequence 2:	NP_001016998.1	Gene:	u2af2 / 549752	XenbaseID:	XB-GENE-494184	Length:	465	Species:	Xenopus tropicalis

Alignment Length:	484	Identity:	448/484 - (92%)
Similarity:	451/484 - (93%)	Gaps:	28/484 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSDFDEFERQLNENKQERDKENRHRKRSHSRSRSRDRKRRSRSRDRRNRDQRSASRDRRRRSKPL 65
            |||||||||||||||||||||||||||||||||||||||||||||||.|:|||.||||||||
Frog     1 MSDFDEFERQLNENKQERDKENRHRKRSHSRSRSRDRKRRSRSRDRRGREQRSGSRDRRRRS--- 62

Human    66 TRGAKEEHGGLIRSPRHEKKKKVRKYWDVPPPGFEHITPMQYKAMQAAGQIPATALLPTMTPDGL 130
                        ||||||||||:||||||||||||||||||||||||||||||||||||||||||
Frog    63 ------------RSPRHEKKKKIRKYWDVPPPGFEHITPMQYKAMQAAGQIPATALLPTMTPDGL 115

Human   131 AVTPTPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQINQDK 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   116 AVTPTPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQINQDK 180

Human   196 NFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSENPSVYVPGVVSTVVPDSAHK 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   181 NFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSENPSVYVPGVVSTVVPDSAHK 245

Human   261 LFIGGLPNYLNDDQ---------VKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTDQA 316
            ||||||||||||||         ||||||||||||||||||||||||||||||||||||||||||
Frog   246 LFIGGLPNYLNDDQVTMESLSLWVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTDQA 310

Human   317 IAGLNGMQLGDKKLLVQRASVGAKNATLVSPPSTINQTPVTLQVPGLMSSQVQMGGHPTEVLCLM 381
            ||||||||||||||||||||||||||||    |||||||||||||||||||||||||||||||||
Frog   311 IAGLNGMQLGDKKLLVQRASVGAKNATL----STINQTPVTLQVPGLMSSQVQMGGHPTEVLCLM 371

Human   382 NMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGVEVPGCGKIFVEFTSVFDCQKAM 446
            |||||||||||:|||||||||||||.|||.|||||||||||||||||||||||||||||||||||
Frog   372 NMVLPEELLDDDEYEEIVEDVRDECGKYGAVKSIEIPRPVDGVEVPGCGKIFVEFTSVFDCQKAM 436

Human   447 QGLTGRKFANRVVVTKYCDPDSYHRRDFW 475
            |||||||||||||||||||||.|||||||
Frog   437 QGLTGRKFANRVVVTKYCDPDGYHRRDFW 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
U2AF2	NP_009210.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..90		69/88 (78%)
		Required for interaction with PRPF19. /evidence=ECO:0000269\|PubMed:21536736	2..93		71/90 (79%)
		Necessary and sufficient to stimulate pre-mRNAs 3'-end cleavage in a CFIm complex-dependent manner. /evidence=ECO:0000269\|PubMed:17024186	17..47		29/29 (100%)
		U2AF_lg	63..474	CDD:273727	386/419 (92%)
u2af2	NP_001016998.1	U2AF_lg	4..464	CDD:273727	442/478 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	150	1.000	Domainoid score	I21256
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H110853
Inparanoid	1	1.050	894	1.000	Inparanoid score	I3742
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D160889at32523
OrthoFinder	1	1.000	-	-		FOG0003153
OrthoInspector	1	1.000	-	-		oto148348
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1575
SonicParanoid	1	1.000	-	-		X2550
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.090