DRSC/TRiP Functional Genomics Resources

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Protein Alignment U2AF2 and u2af2b

DIOPT Version :10

Sequence 1:NP_009210.1 Gene:U2AF2 / 11338 HGNCID:23156 Length:475 Species:Homo sapiens
Sequence 2:XP_009292306.1 Gene:u2af2b / 402989 ZFINID:ZDB-GENE-040426-1881 Length:480 Species:Danio rerio


Alignment Length:488 Identity:412/488 - (84%)
Similarity:441/488 - (90%) Gaps:21/488 - (4%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSDFDEFERQLNENKQ-------ERDKENRHRKRSHSRSRSRDRKRRSRSRDRRNRDQRSASRDR 58
            |||||||||||:||||       |||||||||:||.||||||:|||  |||:||:|::|..|::|
Zfish     1 MSDFDEFERQLSENKQGDSLNGHERDKENRHRRRSPSRSRSRERKR--RSRERRSRERRGDSKER 63

Human    59 RRRSKPLTRGAKEEHGGLIRSPRHEKKKKVRKYWDVPPPGFEHITPMQYKAMQAAGQIPATALLP 123
            |.|....|:...:|:  :.|||..|||||::||||||||||||||||||||||||||||||||||
Zfish    64 RHRRSDHTQNHPQEN--VSRSPHREKKKKIKKYWDVPPPGFEHITPMQYKAMQAAGQIPATALLP 126

Human   124 TMTPDGLAVTPTPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLA 188
            ||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||
Zfish   127 TMTPDGLAVTPTPVPVVGSQMTRQARRLYVGNIPFGITEESMMDFFNAQMRLGGLTQAPGNPVLA 191

Human   189 VQINQDKNFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSENPSVYVP-----G 248
            ||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||     |
Zfish   192 VQINQDKNFAFLEFRSVDETTQAMAFDGIIFQAQSLKIRRPHDYQPLPGMSENPSVYVPAVQFQG 256

Human   249 VVSTVVPDSAHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVT 313
            |||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||:||.
Zfish   257 VVSTVVPDSIHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDVNVN 321

Human   314 DQAIAGLNGMQLGDKKLLVQRASVGAKNATLVSPPSTINQTPVTLQVPGLMSS-QVQMGGHPTEV 377
            ||||||||||||.|||||||||||||||||:.|    ||:||||||||||.|: .:||||.||||
Zfish   322 DQAIAGLNGMQLADKKLLVQRASVGAKNATMTS----INETPVTLQVPGLTSNPMIQMGGIPTEV 382

Human   378 LCLMNMVLPEELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGVEVPGCGKIFVEFTSVFDC 442
            |||||||.||||:||||||||||||::||||||.||||||||||||:::||.||||||||||:|.
Zfish   383 LCLMNMVAPEELIDDEEYEEIVEDVKEECSKYGQVKSIEIPRPVDGLDIPGTGKIFVEFTSVYDS 447

Human   443 QKAMQGLTGRKFANRVVVTKYCDPDSYHRRDFW 475
            |||||||||||||||||||||||||:|||||||
Zfish   448 QKAMQGLTGRKFANRVVVTKYCDPDAYHRRDFW 480

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
U2AF2NP_009210.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..90 56/95 (59%)
Required for interaction with PRPF19. /evidence=ECO:0000269|PubMed:21536736 2..93 57/97 (59%)
Necessary and sufficient to stimulate pre-mRNAs 3'-end cleavage in a CFIm complex-dependent manner. /evidence=ECO:0000269|PubMed:17024186 17..47 23/29 (79%)
U2AF_lg 63..474 CDD:273727 363/416 (87%)
u2af2bXP_009292306.1 U2AF_lg 59..479 CDD:273727 367/425 (86%)

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