DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment U2AF2 and U2af50

DIOPT Version :9

Sequence 1:	NP_009210.1	Gene:	U2AF2 / 11338	HGNCID:	23156	Length:	475	Species:	Homo sapiens
Sequence 2:	NP_001245708.1	Gene:	U2af50 / 32602	FlyBaseID:	FBgn0005411	Length:	427	Species:	Drosophila melanogaster

Alignment Length:	478	Identity:	310/478 - (64%)
Similarity:	360/478 - (75%)	Gaps:	60/478 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     3 DFDEFERQLNENKQERDKENRHRKRSHSRSRSRDRKRRSRSRDRRNRDQRSASRDRRRRSKPLTR 67
            :|::....::...:|||:|.|..     ||||||| .|.||||||:.        |..|.||
  Fly     4 NFEDKYVNIDNKDRERDRERRRH-----RSRSRDR-HRERSRDRRHH--------RNSRRKP--- 51

Human    68 GAKEEHGGLIRSPRHEKKKKVRKYWDVPPPGFEHITPMQYKAMQAAGQIPATALLPTMTPDGLAV 132
                                 ..||||||||||||||||||||||:|||||     ::.||
  Fly    52 ---------------------SLYWDVPPPGFEHITPMQYKAMQASGQIPA-----SVVPD---- 86

Human   133 TP-TPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQINQDKN 196
            || |.||||||.:|||||||||||||||:|||.||:|||.||.|.||.||.|:||||.|||.|||
  Fly    87 TPQTAVPVVGSTITRQARRLYVGNIPFGVTEEEMMEFFNQQMHLVGLAQAAGSPVLACQINLDKN 151

Human   197 FAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSE----NPSVYVPGVVSTVVPDS 257
            ||||||||:||||||||||||..:||||||||||||||:||:::    .|:|...||:|||||||
  Fly   152 FAFLEFRSIDETTQAMAFDGINLKGQSLKIRRPHDYQPMPGITDTPAIKPAVVSSGVISTVVPDS 216

Human   258 AHKLFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTDQAIAGLNG 322
            .||:||||||||||||||||||.|||.|:|||||||:|||||||||||||||:::|||:||||||
  Fly   217 PHKIFIGGLPNYLNDDQVKELLLSFGKLRAFNLVKDAATGLSKGYAFCEYVDLSITDQSIAGLNG 281

Human   323 MQLGDKKLLVQRASVGAKNATLVSPPSTINQT-PVTLQVPGLMSSQVQMGGHPTEVLCLMNMVLP 386
            ||||||||:|||||||||||     .:..|.| .|.||||||  |.|...|.|||||||:|||.|
  Fly   282 MQLGDKKLIVQRASVGAKNA-----QNAANTTQSVMLQVPGL--SNVVTSGPPTEVLCLLNMVTP 339

Human   387 EELLDDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGVEVPGCGKIFVEFTSVFDCQKAMQGLTG 451
            :||.|:||||:|:||:::||:|||:|:|:|||||::|||||||||:||||.||.|||||.|.|||
  Fly   340 DELRDEEEYEDILEDIKEECTKYGVVRSVEIPRPIEGVEVPGCGKVFVEFNSVLDCQKAQQALTG 404

Human   452 RKFANRVVVTKYCDPDSYHRRDF 474
            |||::|||||.|.|||.||||:|
  Fly   405 RKFSDRVVVTSYFDPDKYHRREF 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
U2AF2	NP_009210.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..90		24/86 (28%)
		Required for interaction with PRPF19. /evidence=ECO:0000269\|PubMed:21536736	2..93		25/89 (28%)
		Necessary and sufficient to stimulate pre-mRNAs 3'-end cleavage in a CFIm complex-dependent manner. /evidence=ECO:0000269\|PubMed:17024186	17..47		17/29 (59%)
		U2AF_lg	63..474	CDD:273727	287/416 (69%)
U2af50	NP_001245708.1	RRM1_U2AF65	103..184	CDD:240676	65/80 (81%)
		RRM2_U2AF65	218..294	CDD:240677	65/75 (87%)
		RRM3_U2AF65	328..415	CDD:240678	63/86 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145395
Domainoid	1	1.000	131	1.000	Domainoid score	I5180
eggNOG	1	0.900	-	-		E1_KOG0120
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H110853
Inparanoid	1	1.050	581	1.000	Inparanoid score	I1020
Isobase	1	0.950	-	0	Normalized mean entropy	S1673
OMA	1	1.010	-	-		QHG51929
OrthoDB	1	1.010	-	-		D391481at33208
OrthoFinder	1	1.000	-	-		FOG0003153
OrthoInspector	1	1.000	-	-		oto90876
orthoMCL	1	0.900	-	-		OOG6_101356
Panther	1	1.100	-	-	LDO	PTHR23139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1575
SonicParanoid	1	1.000	-	-		X2550
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750