Protein Alignment U2AF2 and U2af2

DIOPT Version :10

• Sequence 1: NP_009210.1
• Gene: U2AF2 / 11338
• HGNCID: 23156
• Length: 475
• Species: Homo sapiens
• Sequence 2: NP_001414127.1
• Gene: U2af2 / 308335
• RGDID: 1310690
• Length: 475
• Species: Rattus norvegicus
• Alignment Length: 475
• Identity: 474/475 - (99%)
• Similarity: 474/475 - (99%)
• Gaps: 0/475 - (0%)

Human     1 MSDFDEFERQLNENKQERDKENRHRKRSHSRSRSRDRKRRSRSRDRRNRDQRSASRDRRRRSKPL 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MSDFDEFERQLNENKQERDKENRHRKRSHSRSRSRDRKRRSRSRDRRNRDQRSASRDRRRRSKPL 65

Human    66 TRGAKEEHGGLIRSPRHEKKKKVRKYWDVPPPGFEHITPMQYKAMQAAGQIPATALLPTMTPDGL 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 TRGAKEEHGGLIRSPRHEKKKKVRKYWDVPPPGFEHITPMQYKAMQAAGQIPATALLPTMTPDGL 130

Human   131 AVTPTPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQINQDK 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 AVTPTPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQINQDK 195

Human   196 NFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSENPSVYVPGVVSTVVPDSAHK 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 NFAFLEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSENPSVYVPGVVSTVVPDSAHK 260

Human   261 LFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTDQAIAGLNGMQL 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 LFIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTDQAIAGLNGMQL 325

Human   326 GDKKLLVQRASVGAKNATLVSPPSTINQTPVTLQVPGLMSSQVQMGGHPTEVLCLMNMVLPEELL 390
            |||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||
  Rat   326 GDKKLLVQRASVGAKNATLVSLPSTINQTPVTLQVPGLMSSQVQMGGHPTEVLCLMNMVLPEELL 390

Human   391 DDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGVEVPGCGKIFVEFTSVFDCQKAMQGLTGRKFA 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   391 DDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGVEVPGCGKIFVEFTSVFDCQKAMQGLTGRKFA 455

Human   456 NRVVVTKYCDPDSYHRRDFW 475
            ||||||||||||||||||||
  Rat   456 NRVVVTKYCDPDSYHRRDFW 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
U2AF2	NP_009210.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..90		88/88 (100%)
		Required for interaction with PRPF19. /evidence=ECO:0000269|PubMed:21536736	2..93		90/90 (100%)
		Necessary and sufficient to stimulate pre-mRNAs 3'-end cleavage in a CFIm complex-dependent manner. /evidence=ECO:0000269|PubMed:17024186	17..47		29/29 (100%)
		U2AF_lg	63..474	CDD:273727	409/410 (100%)
U2af2	NP_001414127.1	None