Protein Alignment U2AF2 and prp2

DIOPT Version :10

• Sequence 1: NP_009210.1
• Gene: U2AF2 / 11338
• HGNCID: 23156
• Length: 475
• Species: Homo sapiens
• Sequence 2: NP_595396.1
• Gene: prp2 / 2539645
• PomBaseID: SPBC146.07
• Length: 517
• Species: Schizosaccharomyces pombe
• Alignment Length: 524
• Identity: 154/524 - (29%)
• Similarity: 237/524 - (45%)
• Gaps: 86/524 - (16%)

Human    14 NKQERDKENRHRK----------RSHSRSRSRDRKRRSRSRDRRNRDQRSAS-----RDRRRRS- 62
            ::..||:|.|..:          |.|..|....|:||..|..||:|:.|..|     |.||.|.
pombe    18 HRDYRDEEPRRERGSGGIGREDPRGHYGSERPRRRRRDESDFRRHRESRERSYREDERPRRERRY 82

Human    63 ---KPLTRGAKEEHGGLIRSPRHEKKKKV----------------------RKYWDVPPPGFEHI 102
               :|  |..:....|..|||...:::.|                      |..||:.|||:|.:
pombe    83 DDYEP--RSLRYSSVGRSRSPPPSRERSVRSIEQELEQLRDVTPINQWKRKRSLWDIKPPGYELV 145

Human   103 TPMQYK---------AMQAAGQIPATALLPTMTPDGLAVTPTPVPVVGSQMTRQARRLYVGNIPF 158
            |..|.|         |.:||...|...|....:.:|..:.|.|....|:  :||||||.|..||.
pombe   146 TADQAKMSGVFPLPGAPRAAVTDPEKLLEFARSAEGSIIAPPPPLQPGA--SRQARRLVVTGIPN 208

Human   159 GITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQINQDKNFAFLEFRSVDETT-----QAMAFDGII 218
            ...|:|.:.|...........:.......:|.:.:::|||.||..:.::.|     |:.::...:
pombe   209 EFVEDAFVSFIEDLFISTTYHKPETKHFSSVNVCKEENFAILEVATPEDATFLWGLQSESYSNDV 273

Human   219 FQGQSLKIRRPHDY---QPLPGMSENPSVYVPGVVSTVVPDSAHKLFIGGLPNYLNDDQVKELLT 280
            |    ||.:|..:|   |..|.:|:..|   .......|.||..|::|..||..|.:|||.|||.
pombe   274 F----LKFQRIQNYIVPQITPEVSQKRS---DDYAKNDVLDSKDKIYISNLPLNLGEDQVVELLK 331

Human   281 SFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTDQAIAGLNGMQLGDKKLLVQRASVGAKNATLV 345
            .||.|.:|.|:|:.|.|.|||:.|||:.:.:..:.||:||:|......||..|.|.||...|.:
pombe   332 PFGDLLSFQLIKNIADGSSKGFCFCEFKNPSDAEVAISGLDGKDTYGNKLHAQFACVGLNQAMI- 395

Human   346 SPPSTINQTPVTLQVPGLMSSQVQMGGHPTEVLCLMNMVLPEELLDDEEYEEIVEDVRDECSKYG 410
               ...|...:..::....|..:     ||.||.|.|::..:|::|.:|||:|.|.|:.:.|.||
pombe   396 ---DKSNGMAILTELAKASSQSI-----PTRVLQLHNLITGDEIMDVQEYEDIYESVKTQFSNYG 452

Human   411 LVKSIEIPRPV----DGVEVPGCGKIFVEFTSVFDCQKAMQGLTGRKFANRVVVTKYCDPDSYHR 471
            .:..|:|||.:    .|:   |.||:||.::.:...:.||:.:.|.||.:|.:|..:...|.| :
pombe   453 PLIDIKIPRSIGTRNSGL---GTGKVFVRYSDIRSAEVAMEEMKGCKFNDRTIVIAFYGEDCY-K 513

Human   472 RDFW 475
            .:.|
pombe   514 ANAW 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
U2AF2	NP_009210.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..90		27/116 (23%)
		Required for interaction with PRPF19. /evidence=ECO:0000269|PubMed:21536736	2..93		28/119 (24%)
		Necessary and sufficient to stimulate pre-mRNAs 3'-end cleavage in a CFIm complex-dependent manner. /evidence=ECO:0000269|PubMed:17024186	17..47		11/39 (28%)
		U2AF_lg	63..474	CDD:273727	133/453 (29%)
prp2	NP_595396.1	U2AF_lg	22..517	CDD:273727	153/518 (30%)