Protein Alignment U2AF2 and uaf-1

DIOPT Version :10

• Sequence 1: NP_009210.1
• Gene: U2AF2 / 11338
• HGNCID: 23156
• Length: 475
• Species: Homo sapiens
• Sequence 2: NP_001022967.1
• Gene: uaf-1 / 175270
• WormBaseID: WBGene00006697
• Length: 496
• Species: Caenorhabditis elegans
• Alignment Length: 475
• Identity: 272/475 - (57%)
• Similarity: 320/475 - (67%)
• Gaps: 50/475 - (10%)

Human    19 DKENRHRKRSHSRSRSRDRKRRSRSRDRRNR--------DQRSASRDRRR----RSKPLTRGAKE 71
            :.:|..:||..||||.||.:||||||||..|        ..||.||:|||    |.:|..||..:
 Worm    53 EDDNDRKKRKRSRSRDRDTRRRSRSRDRGERRGGGGGGDRDRSRSRERRRGGGGRDEPRRRGGDD 117

Human    72 EHGGLIRSPRHEKKKKVRKY--WDVPPPGFEHITPMQYKAMQAAGQIPATALLPTMTPDGLAVTP 134
            |.... |.|..:|.::.:||  |||||.|||..|||:||.||||||:|..::            .
 Worm   118 EARSR-REPEPQKPREPKKYRFWDVPPTGFETTTPMEYKNMQAAGQVPRGSV------------Q 169

Human   135 TPVPVVGSQMTRQARRLYVGNIPFGITEEAMMDFFNAQMRLGGLTQAPGNPVLAVQINQDKNFAF 199
            :.|||||..:|.|:|||||||||||..||||:||||.||.|.||.||||||:|..|||.||||||
 Worm   170 SAVPVVGPSVTCQSRRLYVGNIPFGCNEEAMLDFFNQQMHLCGLAQAPGNPILLCQINLDKNFAF 234

Human   200 LEFRSVDETTQAMAFDGIIFQGQSLKIRRPHDYQPLPGMSENP---SVYVPGVVSTVVPDSAHKL 261
            :||||:||||..||||||.|.||.||:|||.||||    |:|.   :..:|  |||:|.|||:|:
 Worm   235 IEFRSIDETTAGMAFDGINFMGQQLKVRRPRDYQP----SQNTFDMNSRMP--VSTIVVDSANKI 293

Human   262 FIGGLPNYLNDDQVKELLTSFGPLKAFNLVKDSATGLSKGYAFCEYVDINVTDQAIAGLNGMQLG 326
            |||||||||.:|||||||.||||||||:|..|| .|.||||||.||:|..:||||||||||||||
 Worm   294 FIGGLPNYLTEDQVKELLCSFGPLKAFSLNVDS-QGNSKGYAFAEYLDPTLTDQAIAGLNGMQLG 357

Human   327 DKKLLVQRASVGAK--NATLVSPPSTINQTPVTLQVPGLMSSQVQMGGHPTEVLCLMNMVLPEEL 389
            ||:|:||.|....:  |..|.:..|.|         .|:..|  |..|..||:|||||||..:||
 Worm   358 DKQLVVQLACANQQRHNTNLPNSASAI---------AGIDLS--QGAGRATEILCLMNMVTEDEL 411

Human   390 LDDEEYEEIVEDVRDECSKYGLVKSIEIPRPVDGVEVPGCGKIFVEFTSVFDCQKAMQGLTGRKF 454
            ..|:|||||:|||||||||||:|:|:|||||.:...|||.||:||||.|..|||:|...||||||
 Worm   412 KADDEYEEILEDVRDECSKYGIVRSLEIPRPYEDHPVPGVGKVFVEFASTSDCQRAQAALTGRKF 476

Human   455 ANRVVVTKYCDPDSYHRRDF 474
            |||.|||.|.|.|.||.|.|
 Worm   477 ANRTVVTSYYDVDKYHNRQF 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
U2AF2	NP_009210.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..90		33/82 (40%)
		Required for interaction with PRPF19. /evidence=ECO:0000269|PubMed:21536736	2..93		35/87 (40%)
		Necessary and sufficient to stimulate pre-mRNAs 3'-end cleavage in a CFIm complex-dependent manner. /evidence=ECO:0000269|PubMed:17024186	17..47		16/27 (59%)
		U2AF_lg	63..474	CDD:273727	245/417 (59%)
uaf-1	NP_001022967.1	U2AF_lg	118..496	CDD:273727	242/408 (59%)