DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CBX3 and cbx3a

DIOPT Version :9

Sequence 1:	NP_009207.2	Gene:	CBX3 / 11335	HGNCID:	1553	Length:	183	Species:	Homo sapiens
Sequence 2:	XP_005173826.1	Gene:	cbx3a / 751689	ZFINID:	ZDB-GENE-030131-1158	Length:	177	Species:	Danio rerio

Alignment Length:	175	Identity:	138/175 - (78%)
Similarity:	154/175 - (88%)	Gaps:	3/175 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    11 MGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADNTWEPEENLDCPELIEA 75
            |||||.||||| |..|.||||||||:|:||||||||:||||||||||||||||||||||||||.|
Zfish     4 MGKKQAGKSKK-EVQEIEEFVVEKVMDQRVVNGKVEFFLKWKGFTDADNTWEPEENLDCPELIAA 67

Human    76 FLNSQKAGKEK-DGTKRKSLSDS-ESDDSKSKKKRDAADKPRGFARGLDPERIIGATDSSGELMF 138
            ||.|||...|| :..||||.:|. |:::||:|:|::.:||||||||.|:||||||||||||||||
Zfish    68 FLESQKGVVEKPEAVKRKSSTDEPETEESKAKRKKEMSDKPRGFARNLEPERIIGATDSSGELMF 132

Human   139 LMKWKDSDEADLVLAKEANMKCPQIVIAFYEERLTWHSCPEDEAQ 183
            |||||||||||||.|:|||.:||||||||||||||||||||||.|
Zfish   133 LMKWKDSDEADLVPAREANTRCPQIVIAFYEERLTWHSCPEDEQQ 177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CBX3	NP_009207.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		12/16 (75%)
		CD_HP1gamma_Cbx3	29..78	CDD:349299	44/48 (92%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	79..125		25/47 (53%)
		CSD_HP1gamma_Cbx3	116..173	CDD:349303	50/56 (89%)
cbx3a	XP_005173826.1	Chromo	23..71	CDD:278797	43/47 (91%)
cbx3a	XP_005173826.1	Chromo_shadow	116..167	CDD:279701	45/50 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194325713
Domainoid	1	1.000	99	1.000	Domainoid score	I26242
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40583
Inparanoid	1	1.050	276	1.000	Inparanoid score	I9892
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52905
OrthoDB	1	1.010	-	-		D1628171at2759
OrthoFinder	1	1.000	-	-		FOG0000191
OrthoInspector	1	1.000	-	-		oto48641
orthoMCL	1	0.900	-	-		OOG6_104220
Panther	1	1.100	-	-	LDO	PTHR22812
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8954
SonicParanoid	1	1.000	-	-		X422
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.440