DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CBX3 and HP1b

DIOPT Version :9

Sequence 1:	NP_009207.2	Gene:	CBX3 / 11335	HGNCID:	1553	Length:	183	Species:	Homo sapiens
Sequence 2:	NP_001162713.1	Gene:	HP1b / 31834	FlyBaseID:	FBgn0030082	Length:	240	Species:	Drosophila melanogaster

Alignment Length:	154	Identity:	87/154 - (56%)
Similarity:	109/154 - (70%)	Gaps:	8/154 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    29 EFVVEKVLDRRVVNGKVEYFLKWKGFTDADNTWEPEENLDCPELIEAFLNSQKAGKEKDGTKRKS 93
            ||.||:|.|:|.|||:.||:|||||:..::|||||.||||||:||..|..|.|..|::  ||::.
  Fly     3 EFSVERVEDKRTVNGRTEYYLKWKGYPRSENTWEPVENLDCPDLIANFEESLKNNKKE--TKKRL 65

Human    94 LSDSESDDSKSKKKRDAAD------KPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVL 152
            .:.|..:..:||:|....|      |..||.|||:..:|:|||||||.||||||||.||.||||.
  Fly    66 STSSTPESIRSKRKSFLEDDTEEQKKLIGFERGLEASKILGATDSSGHLMFLMKWKGSDHADLVP 130

Human   153 AKEANMKCPQIVIAFYEERLTWHS 176
            ||.||.:|||:||.|||||||||:
  Fly   131 AKLANTRCPQVVIQFYEERLTWHT 154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CBX3	NP_009207.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		CD_HP1gamma_Cbx3	29..78	CDD:349299	31/48 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	79..125		16/51 (31%)
		CSD_HP1gamma_Cbx3	116..173	CDD:349303	41/56 (73%)
HP1b	NP_001162713.1	CHROMO	3..52	CDD:214605	31/48 (65%)
HP1b	NP_001162713.1	Chromo_shadow	100..151	CDD:279701	36/50 (72%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142984
Domainoid	1	1.000	90	1.000	Domainoid score	I7775
eggNOG	1	0.900	-	-		E1_KOG1911
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	176	1.000	Inparanoid score	I4048
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52905
OrthoDB	1	1.010	-	-		D1628171at2759
OrthoFinder	1	1.000	-	-		FOG0000191
OrthoInspector	1	1.000	-	-		otm40254
orthoMCL	1	0.900	-	-		OOG6_104220
Panther	1	1.100	-	-	LDO	PTHR22812
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8954
SonicParanoid	1	1.000	-	-		X422
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800