Protein Alignment PHB2 and CG14736

DIOPT Version :10

• Sequence 1: NP_001138303.1
• Gene: PHB2 / 11331
• HGNCID: 30306
• Length: 299
• Species: Homo sapiens
• Sequence 2: NP_731666.2
• Gene: CG14736 / 41466
• FlyBaseID: FBgn0037986
• Length: 473
• Species: Drosophila melanogaster
• Alignment Length: 231
• Identity: 53/231 - (22%)
• Similarity: 105/231 - (45%)
• Gaps: 46/231 - (19%)

Human    54 RIGGVQQDTILAEGLHFRIPWFQYPIIYDIR-----ARPRKISSPTGSKDLQMVNISLRV---LS 110
            |:|.:::. :...||.|.:|........|:|     .||:.:.    :||...:.::..|   :.
  Fly    93 RLGRLRKG-LRGPGLVFILPCIDETHRVDMRTDVTNVRPQDVL----TKDSVTITVNAVVYYCIY 152

Human   111 RPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDF 175
            .|    :.|:.|   :|..::....|....|:::|.....:.|:|.|.|:|..|::.:......:
  Fly   153 SP----IDSIIQ---VDDAKQATQLISQVTLRNIVGSKTLNVLLTSRQQLSREIQQAVAGITYRW 210

Human   176 SLILDDVAITELSF--SREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKML 238
            .:.::.|.:.:::.  |.|.:.|.||:.|                :|.|.||:.||||.:|:|.|
  Fly   211 GVRVERVDVMDITLPTSLERSLASEAEAV----------------REARAKIILAEGELKASKAL 259

Human   239 GEA---LSKNPGYIKLRKIRAAQNISKTIATSQNRI 271
            .||   :|:|...::||.::...:|:     |:.|:
  Fly   260 KEASDVMSENKITLQLRHLQILSSIA-----SERRV 290

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PHB2	NP_001138303.1	Necessary for transcriptional repression. /evidence=ECO:0000269|PubMed:10359819	19..49
		SPFH_prohibitin	40..235	CDD:259799	41/190 (22%)
		LC3-interaction region. /evidence=ECO:0000269|PubMed:28017329	121..124		1/2 (50%)
		Necessary for transcriptional repression. /evidence=ECO:0000269|PubMed:10359819	150..174		6/23 (26%)
CG14736	NP_731666.2	SPFH_like	100..305	CDD:473137	51/224 (23%)