back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment STK38 and Pkcdelta

DIOPT Version :10

Sequence 1:	NP_009202.1	Gene:	STK38 / 11329	HGNCID:	17847	Length:	465	Species:	Homo sapiens
Sequence 2:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0287828	Length:	1894	Species:	Drosophila melanogaster

Alignment Length:	376	Identity:	117/376 - (31%)
Similarity:	187/376 - (49%)	Gaps:	62/376 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    86 LEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDIL-VEADSLWV 149
            ::||..|.|:|:|:||:|.|.:.:||.:.||:|.|:|..:||.:.|.....||.:| :.....::
  Fly  1563 VDDFHFLAVLGKGSFGKVLLAELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYL 1627

Human   150 VKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIK 214
            ..:|.:||.:.:|:.:||:|.|||:|..:.:....:||..:||.||.:..:..:|:.|.|:||:|
  Fly  1628 CHLFCTFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLK 1692

Human   215 PDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLA 279
            .||:|||.:|||:::|||:|       :.:.|.:                            :.|
  Fly  1693 LDNVLLDYEGHVRIADFGMC-------KLQIYLD----------------------------KTA 1722

Human   280 FSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFP 344
            .|..|||||:|||:.....||:..||||.||::||||||..||......|.:..:.|  |...||
  Fly  1723 DSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICN--EIPWFP 1785

Human   345 PEVPISEKA----KDLILRFCCEWEHRIGA--PGVEEIKSNSFFEGVDWEHIRER--PAAISIEI 401
              |.||.:|    |.|:.:   ::..|||:  ....:|..:.||..:||..:.:|  ......::
  Fly  1786 --VYISAEATGILKGLLEK---DYTKRIGSQYSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQV 1845

Human   402 KSIDDTSNFDEFPESDILKPTVATSNHPETDYKNKDWVFINYTYKRFEGLT 452
            |...||..||.          |.|.........:|: :..:...|:|.|.|
  Fly  1846 KHPLDTQYFDR----------VFTRERVRLTPIDKE-ILASMDQKQFHGFT 1885

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.