DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FKBP9 and Fkbp14

DIOPT Version :9

Sequence 1:	NP_001271270.1	Gene:	FKBP9 / 11328	HGNCID:	3725	Length:	623	Species:	Homo sapiens
Sequence 2:	NP_001246448.1	Gene:	Fkbp14 / 37449	FlyBaseID:	FBgn0010470	Length:	220	Species:	Drosophila melanogaster

Alignment Length:	355	Identity:	87/355 - (24%)
Similarity:	137/355 - (38%)	Gaps:	162/355 - (45%)

- Green bases have known domain annotations that are detailed below.

Human   294 QASLVFDVALLDLHNPKDSISIENKVV------------PENCERISQSGDFLRYHYNGTL-LDG 345
            :::||....||        ::|.|.:|            ||.||:.|::||.|..||.||| .||
  Fly     3 KSNLVISCLLL--------VAISNSLVRAQDLKVEVISTPEVCEQKSKNGDSLTMHYTGTLQADG 59

Human   346 TLFDSSYSRNRTFDTYIGQGYVIPGMDEGLLGVCIGEKRRIVVPPHLGYGEEGRGNIPGSAVLVF 410
            ..||||:.|::.|...:|.|.||.|.|:|||.:|:||||::.:||.||||::|.||
  Fly    60 KKFDSSFDRDQPFTFQLGAGQVIKGWDQGLLNMCVGEKRKLTIPPQLGYGDQGAGN--------- 115

Human   411 DIHVIDFHNPSDSISITSHYKPPDCSVLSKKGDYLKYHYNASLLDGTLLDSTWNLGKTYNIVLGS 475

  Fly   116 ----------------------------------------------------------------- 115

Human   476 GQVVLGMDMGLREMCVGEKRTVIIPPHLGYGEAGVDGEVPGSAVLVFDIELLELVAGLPEGYMFI 540
                                  :|||               .|.|:||:||:.           |
  Fly   116 ----------------------VIPP---------------KATLLFDVELIN-----------I 132

Human   541 WNGEVSPNLFEEIDKDGNGEVLLEE----FSEYIHAQVASGKGK--------LAPGFDAELIVKN 593
            .|...:.|:|:|||.:.:.::..||    .|||:..|:.:.:|:        ||   :.:.:|:.
  Fly   133 GNAPPTTNVFKEIDDNADKQLSREEVIVYVSEYLKKQMTAVEGQDSEELKNMLA---ENDKLVEE 194

Human   594 MFTNQDRNGDGKVTAEEFKLKDQEAKHDEL 623
            :|.::|::.:|.::.:||    ...|||||
  Fly   195 IFQHEDKDKNGFISHDEF----SGPKHDEL 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FKBP9	NP_001271270.1	FKBP_C	47..191	CDD:278674
		FKBP_C	212..304	CDD:278674	2/9 (22%)
		FKBP_C	324..415	CDD:278674	42/91 (46%)
		FKBP_C	435..527	CDD:278674	8/91 (9%)
		EF-hand_7	548..612	CDD:290234	19/75 (25%)
		EFh	550..611	CDD:238008	17/72 (24%)
Fkbp14	NP_001246448.1	FKBP_C	37..130	CDD:278674	50/203 (25%)
		EF-hand_7	140..212	CDD:290234	18/74 (24%)
		EFh	141..212	CDD:298682	17/73 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1507309at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820