Protein Alignment LARP4 and Larp7

DIOPT Version :10

• Sequence 1: XP_047284158.1
• Gene: LARP4 / 113251
• HGNCID: 24320
• Length: 738
• Species: Homo sapiens
• Sequence 2: NP_524795.2
• Gene: Larp7 / 44900
• FlyBaseID: FBgn0260771
• Length: 595
• Species: Drosophila melanogaster
• Alignment Length: 674
• Identity: 133/674 - (19%)
• Similarity: 216/674 - (32%)
• Gaps: 196/674 - (29%)

Human   110 PEDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRENLSKDLYLISQMDSDQFIPIWTVANM 174
            |||.|....| .|....    ..|...::.|:||.|...|||||.:|...::.|.::|:......
  Fly    41 PEDASPDKKD-GGRKRK----RHLFNSIRGQMEFYFGDANLSKDRFLRRYVEQDPYVPLEIFLTF 100

Human   175 EEIKKLTTDPDLILEVLRSSPMVQVDEKGEKVR-----PSHKRC---IVILREIPETTPIEEVKG 231
            .:||.||.|...|.:.|.:|.::::||...||:     |..:..   .:.:..:|.....:.:|.
  Fly   101 NKIKTLTQDVQQIAKALSNSQLLELDETELKVKRRTKLPDQRDVNDKTLYVEALPANATHDWLKE 165

Human   232 LFKSENCPKVISC----------EFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMARIK 286
            :|........:|.          |||     :|.|:.....::|       ||.|      |:|:
  Fly   166 VFSRYGPVAYVSLPHYPGTKKIKEFA-----FIEFEKSGSLEKA-------VKAF------AQIQ 212

Human   287 AINTFFAKNGYRLMDSSIYSHPIQTQAQYASPVFMQPVYNPHQQYSVYSIVPQSWSPNPTPYFET 351
            .:.:                  ::|     .|..:..|.:..||..:.....|       |..|.
  Fly   213 GVLS------------------VET-----DPSDLASVRSFQQQQQIQQKAEQ-------PQSEA 247

Human   352 PLAPFPNGSFVNGFNSPGSYKTNAAAMNMGRPFQKNRVK-----PQFRSSGG---SEHSTEGSVS 408
            .....|..:.          |..|...:.....:..|||     |...|:.|   ||...||:..
  Fly   248 EQVELPKRNL----------KREATDKDREEIHEVKRVKLEEGQPSETSTAGETASETDAEGTAE 302

Human   409 LG---------DGQ---LNRYSSRNFPAERHNPTVTGHQEQTYLQKETSTLQVE----------Q 451
            ..         ||.   ..|...|...|....|.:           |.|.|:::          :
  Fly   303 ASEQEDKTEATDGDEAAKKRRRKRKKKAIVDKPNI-----------EPSALELKVLPKTSWSSMR 356

Human   452 NGDYGRGRRTLFRGRRR--REDDRISRPHPSTAESKAPTPKFDLLASNFPPLPGSSSRMPGELVL 514
            |......||.:...:.:  ||:...::.||...::..|         |.|    ..|::| |.|.
  Fly   357 NKYLNLQRRIVSEAKSKLWRENHPQNQQHPHHQQTSHP---------NHP----KPSQLP-EAVK 407

Human   515 ENRMSDVVKGVYKEKDNEELTISCPVPADEQTECTSAQQLNMSTSSPCAAELTALSTTQQEKDLI 579
            |....    |.......|....:.||||..:   .:..::||:.......|.|......||:
  Fly   408 EEETG----GEVPSDGGEGAVEAAPVPAKRR---KAVHKMNMNFYGAGGVESTKSEEPSQER--- 462

Human   580 EDSSVQKDGLNQTTIPVSPPSTTKPS---RASTASPCNNNINAATAVALQEPRKLSYAEVCQKPP 641
                             :|....:|.   ..|...|| .|:....|...|.| .:.|.::
  Fly   463 -----------------TPLFKYEPGLIVECSLLKPC-TNVKEFKAEMRQYP-DIKYVDI----- 503

Human   642 KEPSSVLVQPLRELRSNVVSPTKNEDNGAPENSVEKPHEKPEARASKDYSGFRGNIIPRGAAGKI 706
            ||...|.:..|.       :|...|:.....|..|        |..|..||.:..:..|    ||
  Fly   504 KEGDQVALLRLG-------TPAAAEELLRQVNCSE--------RQLKVLSGQQETLYWR----KI 549

Human   707 REQRRQFSHRAIPQGVTRRNGKEQ 730
            .:.|.....:.:  .|.::.|:|:
  Fly   550 EQDREAKLSKKV--RVQQKRGREK 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LARP4	XP_047284158.1	LARP_4	134..208	CDD:153404	24/78 (31%)
		RRM_LARP4	213..289	CDD:410106	15/88 (17%)
Larp7	NP_524795.2	LA	57..135	CDD:128955	25/77 (32%)
		RRM1_LARP7	148..220	CDD:409732	16/112 (14%)
		RRM2_LARP7	471..548	CDD:409958	21/102 (21%)