Protein Alignment LARP4 and Larp4B

DIOPT Version :10

• Sequence 1: XP_047284158.1
• Gene: LARP4 / 113251
• HGNCID: 24320
• Length: 738
• Species: Homo sapiens
• Sequence 2: NP_647793.1
• Gene: Larp4B / 38399
• FlyBaseID: FBgn0035424
• Length: 1531
• Species: Drosophila melanogaster
• Alignment Length: 812
• Identity: 221/812 - (27%)
• Similarity: 346/812 - (42%)
• Gaps: 195/812 - (24%)

Human    40 ATPVTHGTESSWHEIAATSGAHPEVS---VFNTGNAELSEDICKEYEVMYSSSCETTRNTTGIEE 101
            |..:|:|.:.:..:  ||:|....:|   |..:|.....:| ..||.:| :.:...|::.|.:..
  Fly   144 AQHLTYGHQPALSQ--ATAGGSGTISGGAVGPSGVVVEGQD-TNEYAIM-NGALGQTQDGTVVCY 204

Human   102 STDGM--------------ILGPEDLSYQI------------------YDVSGESNSAVSTEDLK 134
            :||.:              |:.|..:..|:                  ::.:|.....:..:.||
  Fly   205 TTDALNNTNLVALDPQPHQIVVPVQVPVQVPVPVQLPANGSADPQQGSHNAAGGEEPNIPLDKLK 269

Human   135 ECLKKQLEFCFSRENLSKDLYLISQMDSDQFIPIWTVANMEEIKKLTTDPDLILEVLRSSPMVQV 199
            :.|..|||:.||||||:.|.||:|||||||::||:|||....::|||.|.:||.||||.||.|||
  Fly   270 QMLATQLEYYFSRENLANDTYLLSQMDSDQYVPIYTVARFNLVRKLTNDINLITEVLRESPNVQV 334

Human   200 DEKGEKVRPSHKRCIVILREIPETTPIEEVKGLFKSENCPKVISCEFAHNSNWYITFQSDTDAQQ 264
            |:||.:|||:.||||:|||||...||:::||.||.:|:||:.||||||.|::|||||:||.|||:
  Fly   335 DDKGLRVRPNRKRCIIILREISNNTPLDDVKALFSNESCPRPISCEFAANNSWYITFESDEDAQK 399

Human   265 AFKYLREEVKTFQGKPIMARIKA---INTFFA--KNGYRLMD-------------SSIYSHPIQT 311
            |:||||||||.|||||||||||.   ||...|  ||||||..             .:..|:....
  Fly   400 AYKYLREEVKEFQGKPIMARIKPKSFINRIQAVPKNGYRLTSPPTANVFDPAGAGGATVSYAAAQ 464

Human   312 QAQY--------ASPVFMQ---PVYNPHQQYSVY-SIVPQSWSP--------------------- 343
            |.:|        |:|..:|   ||..|..|...| .:|...|.|
  Fly   465 QPRYLYTNGAAIAAPASVQYSNPVLIPIPQNQFYPGLVAGPWPPGTVAATTAHGQNFYELGGNIF 529

Human   344 --NPTP-------YFETP-------LAPFPNGSFVNGFNSPGSYKTNAAAMNMGRPFQKNRVKPQ 392
              ||.|       :.:.|       :.|.|.|......|..|: ..|....|.| |..::|.||.
  Fly   530 TTNPLPPQPVTAGFAQAPPPTSQAMVTPKPQGGGRYNNNHRGN-PNNVGGANSG-PRAESRSKPP 592

Human   393 FRSSGGSEHSTEGSV-------SLGDGQLNRYSSRNFPAERHNPTVTGHQEQTYL----QKETST 446
             ||:..:.|...|::       .:..|.::...: |...:...|.....|.|..:    |:.:|:
  Fly   593 -RSTPSASHIQGGNIMPIQITAPIPGGMVSVVPT-NIVQDPLQPAPLQQQPQQVIQQIQQQPSSS 655

Human   447 LQVEQNGDYGRGRRTL-------FRGRRRREDDR-----ISRPHPSTAESKAPTPKFDLLASNFP 499
            .|.:|.........|.       ::|..::..|:     ::..|..|.:.:|
  Fly   656 AQQQQAATVQMNNTTRHYPIKSNWKGGMQKNLDKSYSGGVATHHHYTTQVQA------------- 707

Human   500 PLPGSSSRMPGELVLENRMSDVVKGVYKEKDNEELTISCPVPADEQTECTSA---QQ-------L 554
             ||..|..:..:..|:.:         .::.:.:|..|....|.:.|..|:|   ||       |
  Fly   708 -LPAHSHHLQAQQQLQGQ---------TQQQHYQLASSSAASAPQVTYVTTAPAPQQPGQHQHHL 762

Human   555 NMSTSSPCAAELTALSTTQQEKDLIEDSSVQKDGLNQTTIPVSPPSTTKPSRASTASPCNNNINA 619
            .:..:.|...:.......||::..:::.....||:..::..:...:.:....||::|....:::.
  Fly   763 VVQQTQPQQQQQQQQVVLQQQQVQVQELQEAGDGVEHSSHAMQQVNRSSNMSASSSSSLATSMSK 827

Human   620 ATAVALQEPRK--------LSYAE-----VCQKPPKEPSSVLVQPLRELR-----SNVVSPTKNE 666
            ........||:        ::|:.     :....|..|     .|.:.|.     |||.|....:
  Fly   828 EPLQWQNRPRRRRRDEEGGINYSPGGRVGLYGSSPSNP-----HPQQHLMSSSTGSNVQSAGGTD 887

Human   667 DNGAPENSVEKP------HEKPEARASKDYSG 692
            ..||.....|:.      |:.|..:...:|.|
  Fly   888 GGGASHRGGERQSHYNTIHDVPPPQHRGNYKG 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LARP4	XP_047284158.1	LARP_4	134..208	CDD:153404	45/73 (62%)
		RRM_LARP4	213..289	CDD:410106	53/78 (68%)
Larp4B	NP_647793.1	LARP_4_5_like	269..343	CDD:153400	45/73 (62%)
		RRM_LARP4_5_like	348..423	CDD:409864	53/74 (72%)