Protein Alignment LARP4 and La

DIOPT Version :10

• Sequence 1: XP_047284158.1
• Gene: LARP4 / 113251
• HGNCID: 24320
• Length: 738
• Species: Homo sapiens
• Sequence 2: NP_477014.1
• Gene: La / 35305
• FlyBaseID: FBgn0011638
• Length: 390
• Species: Drosophila melanogaster
• Alignment Length: 470
• Identity: 78/470 - (16%)
• Similarity: 159/470 - (33%)
• Gaps: 158/470 - (33%)

Human    66 VFNTGNAELSEDICK--EYEVMYSSSCETTRNTTGIEESTDGMILGPEDLSYQIYDVSGESNSAV 128
            |..|.:.|..|::.:  |.:|:.:.:.:..::.....|...|.....|
  Fly     4 VAETPSVEAQEEVAQPAEAQVLEAKNGDAKKDPAPAAEEAAGGFTKQE----------------- 51

Human   129 STEDLKECLKKQLEFCFSRENLSKDLYLISQM--DSDQFIPIWTVANMEEIKKLTTDPDLILEVL 191
                  ..:.:|:|:.|...||::|.:|..|:  :.|.::|:..:...:.:..|:||...|:..|
  Fly    52 ------RAIIRQVEYYFGDANLNRDKFLREQIGKNEDGWVPLSVLVTFKRLASLSTDLSEIVAAL 110

Human   192 RSSP--MVQVDEKGEKVR-------PSH---KRCIVILREIPETT------PIE-EVKGLFK-SE 236
            ..|.  :|::.|....:|       |.|   :|     :||.|.|      |:: ::..|.. :.
  Fly   111 NKSEEGLVEISEDKLSLRRHPERPIPEHNEERR-----KEIQERTAYAKGFPLDSQISELLDFAA 170

Human   237 NCPKVISC-----------EFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMARIKAINT 290
            |..||::.           .:....:.::||::   ..||..:|.:|...::.:.::.:.:.
  Fly   171 NYDKVVNLTMRKHYDKPTKSYKFKGSIFLTFET---KDQAKAFLEQEKIVYKERELLRKWQV--- 229

Human   291 FFAKNGYRLMDSSIYSHPIQTQAQYASPVFMQPVYNPHQQYSVYSIVPQSWSPNPTPYFETPLAP 355
                           .:..:.|.:||..       |..::        ......|.|.||.|
  Fly   230 ---------------DYLKEKQEEYAQK-------NEKRK--------NKKEAKPEPAFELP--- 261

Human   356 FPNGSFVNGFNSPGSYKTNAAAMNMGRPFQKNR--VKPQFRSSGGSE--------HSTEGSVSLG 410
                             .||..:..|.|...:|  ::..|......|        ..|:|||.|.
  Fly   262 -----------------KNAIVVFEGAPETSSREEIREAFEKIKDFEVAYIEFAKGETKGSVRLT 309

Human   411 DGQLNRYSSRNFPAERHNPTV------------------TGHQEQTYLQKETSTLQVEQNGDYGR 457
            :..         .||::...|                  |..:|:.::.|....::..::....:
  Fly   310 EAD---------AAEKYIAKVEEGKLKFKDEVSLSLRKATEEEEKEFIDKAIEFMKKRRDFTRNK 365

Human   458 GRRTLFRGRRRREDD 472
            |:|  |..:|...:|
  Fly   366 GKR--FNRKRHGGND 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LARP4	XP_047284158.1	LARP_4	134..208	CDD:153404	19/84 (23%)
		RRM_LARP4	213..289	CDD:410106	15/94 (16%)
La	NP_477014.1	LARP_3	47..129	CDD:153397	19/104 (18%)
		RRM1_La	150..226	CDD:409733	12/78 (15%)
		RRM2_La	263..338	CDD:409957	15/83 (18%)