DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DDX42 and CG6418

DIOPT Version :9

Sequence 1:	NP_031398.2	Gene:	DDX42 / 11325	HGNCID:	18676	Length:	938	Species:	Homo sapiens
Sequence 2:	NP_648413.1	Gene:	CG6418 / 39218	FlyBaseID:	FBgn0036104	Length:	791	Species:	Drosophila melanogaster

Alignment Length:	842	Identity:	423/842 - (50%)
Similarity:	546/842 - (64%)	Gaps:	99/842 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    12 RGFGFGGF----AISAGKKEEPKLPQQSHSAFGATSSSSGFG---------------KSAPPQLP 57
            ||.|.|||    ..|:|.......|....:|.|.:.|..|||               |.....|.
  Fly     5 RGIGGGGFPYRKPASSGNNMNAVPPPPMLNARGYSGSRGGFGGASRGGVTGSTTSTSKHGYSTLD 69

Human    58 SFYK-------IGSKRANFDEENAYFEDEEED-SSNVDLPYIPAENSPTRQQFHS-KPVDSDSDD 113
            |..:       :|.::.:.|::  ||:|::|. ...::..||||..||......: |..|||||:
  Fly    70 SISQYTNATNLVGKRKHHTDDD--YFDDDDEPREKEIEQAYIPAPGSPGAPPTSAKKQEDSDSDE 132

Human   114 DPLEAFMAEVEDQAARDMKRLEEKDKERKNVK----GIRDDIEEEDDQEAYFRYMAENPTAGVVQ 174
            ||||.|||.:..|.        ||:|.::..|    .:|.||::|||:|:|:|||.|||.||:..
  Fly   133 DPLEQFMAGINQQV--------EKEKRQQAPKPPTQAVRGDIDDEDDEESYYRYMKENPNAGLRD 189

Human   175 EEEEDNLEYDSDGNPIA-PTKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHK 238
            |..:..:|||.|||||| |.||.|||||||.||||:|.|||||||.:|::|..|..:|:.:||..
  Fly   190 EGSDQEIEYDEDGNPIAPPKKKDIDPLPPIYHSEIEYEPFEKNFYTQHDDIAALDDEQVRELRRT 254

Human   239 LNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQGVPVALSGRDMIGIAKTGSGK 303
            |.::|:|.:||:|.:||.||||||||:..:||:|||||||||.|.||.||||||:||||||||||
  Fly   255 LGVKVTGPSPPKPVTSFGHFGFDEQLIKAVRKAEYTQPTPIQAQAVPTALSGRDIIGIAKTGSGK 319

Human   304 TAAFIWPMLIHIMDQKELEPGDGPIAVIVCPTRELCQQIHAECKRFGKAYNLRSVAVYGGGSMWE 368
            |||||||||:|:||||:|:||||||.:|:.|||||..||:.|.|:|||.|||..|..|||||.||
  Fly   320 TAAFIWPMLMHVMDQKQLKPGDGPIGLILAPTRELSLQIYNEAKKFGKVYNLNVVCCYGGGSKWE 384

Human   369 QAKALQEGAEIVVCTPGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQ 433
            |:|||::||||:|.||||:||.||.|||||:||::||.|||||||.||||.|||||.:|||||||
  Fly   385 QSKALEQGAEIIVATPGRMIDMVKMKATNLRRVTFLVLDEADRMFHMGFEPQVRSICNHVRPDRQ 449

Human   434 TLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSS 498
            .|:|||||:|:||:||||:|.||:|:||||:.|||:|:||.|.:..:...|||||...||:|.|.
  Fly   450 CLMFSATFKKRIERLARDVLSDPVRIVQGDLNEANQDITQSVYVFPNPLQKWNWLLCHLVKFLSE 514

Human   499 GSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLD 563
            ||||:|||||.:||.::|||..:.:|..||||||||::|||||:.||:|:..:||||||||||||
  Fly   515 GSVLIFVTKKVDAETVSNNLLIKEYNCLLLHGDMDQADRNKVITQFKRKECDILVATDVAARGLD 579

Human   564 IPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKEL 628
            ||.|:.|:|||.||||:||||||||||||||||.||||:|.||..|||.||||||||:|.|..:|
  Fly   580 IPHIRNVVNYDTARDIETHTHRIGRTGRAGEKGNAYTLVTDKDKEFAGHLVRNLEGADQLVPDDL 644

Human   629 LDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNNNVMSNYEAYKP------ 687
            ::|||:::|||.||||.||||:......||||||:...|......|.:...::..|:.|
  Fly   645 MELAMKSSWFRSSRFKQGKGKRPTNTHTGLGYREKGNGGGGYGSAGGSESTASVSAHSPSDGPSS 709

Human   688 ----STGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQG 748
                |:|...||.|||:.||:|||.:.|.|:|            ...|
  Fly   710 KAFSSSGPATDRYTAMREAFRSQYNNQFRASS------------DRTW----------------- 745

Human   749 HNSPDSPVTSAAKGIPGFGNTGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERY 810
                       .|.:|..|    :..||:..||:..||.:.:::.|:|.:  .....|:.|:
  Fly   746 -----------EKTLPESG----VFAAPMAPPSSSTQGASASSANNSSNQ--DAKRAKKSRW 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DDX42	NP_031398.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..114		36/129 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..203		17/21 (81%)
		Q motif	253..281		20/27 (74%)
		PRK10590	254..688	CDD:236722	286/443 (65%)
		DEADc	255..459	CDD:238167	149/203 (73%)
		DEAD box	407..410		2/2 (100%)
		HELICc	470..601	CDD:238034	85/130 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	737..938		13/74 (18%)
		Necessary for interaction with TP53BP2. /evidence=ECO:0000269\|PubMed:19377511	738..833		13/73 (18%)
CG6418	NP_648413.1	DEADc	271..475	CDD:238167	149/203 (73%)
		DEXDc	284..489	CDD:214692	149/204 (73%)
		Helicase_C	504..609	CDD:278689	70/104 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157087
Domainoid	1	1.000	265	1.000	Domainoid score	I1912
eggNOG	1	0.900	-	-		E2759_KOG0339
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49137
Inparanoid	1	1.050	782	1.000	Inparanoid score	I526
Isobase	1	0.950	-	0	Normalized mean entropy	S1034
OMA	1	1.010	-	-		QHG46804
OrthoDB	1	1.010	-	-		D146665at33208
OrthoFinder	1	1.000	-	-		FOG0005388
OrthoInspector	1	1.000	-	-		oto91091
orthoMCL	1	0.900	-	-		OOG6_104858
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4123
SonicParanoid	1	1.000	-	-		X3817
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750