Protein Alignment DDX42 and CG6418

DIOPT Version :10

• Sequence 1: NP_031398.2
• Gene: DDX42 / 11325
• HGNCID: 18676
• Length: 938
• Species: Homo sapiens
• Sequence 2: NP_648413.1
• Gene: CG6418 / 39218
• FlyBaseID: FBgn0036104
• Length: 791
• Species: Drosophila melanogaster
• Alignment Length: 842
• Identity: 423/842 - (50%)
• Similarity: 546/842 - (64%)
• Gaps: 99/842 - (11%)

Human    12 RGFGFGGF----AISAGKKEEPKLPQQSHSAFGATSSSSGFG---------------KSAPPQLP 57
            ||.|.|||    ..|:|.......|....:|.|.:.|..|||               |.....|.
  Fly     5 RGIGGGGFPYRKPASSGNNMNAVPPPPMLNARGYSGSRGGFGGASRGGVTGSTTSTSKHGYSTLD 69

Human    58 SFYK-------IGSKRANFDEENAYFEDEEED-SSNVDLPYIPAENSPTRQQFHS-KPVDSDSDD 113
            |..:       :|.::.:.|::  ||:|::|. ...::..||||..||......: |..|||||:
  Fly    70 SISQYTNATNLVGKRKHHTDDD--YFDDDDEPREKEIEQAYIPAPGSPGAPPTSAKKQEDSDSDE 132

Human   114 DPLEAFMAEVEDQAARDMKRLEEKDKERKNVK----GIRDDIEEEDDQEAYFRYMAENPTAGVVQ 174
            ||||.|||.:..|.        ||:|.::..|    .:|.||::|||:|:|:|||.|||.||:..
  Fly   133 DPLEQFMAGINQQV--------EKEKRQQAPKPPTQAVRGDIDDEDDEESYYRYMKENPNAGLRD 189

Human   175 EEEEDNLEYDSDGNPIA-PTKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHK 238
            |..:..:|||.|||||| |.||.|||||||.||||:|.|||||||.:|::|..|..:|:.:||..
  Fly   190 EGSDQEIEYDEDGNPIAPPKKKDIDPLPPIYHSEIEYEPFEKNFYTQHDDIAALDDEQVRELRRT 254

Human   239 LNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQGVPVALSGRDMIGIAKTGSGK 303
            |.::|:|.:||:|.:||.||||||||:..:||:|||||||||.|.||.||||||:||||||||||
  Fly   255 LGVKVTGPSPPKPVTSFGHFGFDEQLIKAVRKAEYTQPTPIQAQAVPTALSGRDIIGIAKTGSGK 319

Human   304 TAAFIWPMLIHIMDQKELEPGDGPIAVIVCPTRELCQQIHAECKRFGKAYNLRSVAVYGGGSMWE 368
            |||||||||:|:||||:|:||||||.:|:.|||||..||:.|.|:|||.|||..|..|||||.||
  Fly   320 TAAFIWPMLMHVMDQKQLKPGDGPIGLILAPTRELSLQIYNEAKKFGKVYNLNVVCCYGGGSKWE 384

Human   369 QAKALQEGAEIVVCTPGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQ 433
            |:|||::||||:|.||||:||.||.|||||:||::||.|||||||.||||.|||||.:|||||||
  Fly   385 QSKALEQGAEIIVATPGRMIDMVKMKATNLRRVTFLVLDEADRMFHMGFEPQVRSICNHVRPDRQ 449

Human   434 TLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSS 498
            .|:|||||:|:||:||||:|.||:|:||||:.|||:|:||.|.:..:...|||||...||:|.|.
  Fly   450 CLMFSATFKKRIERLARDVLSDPVRIVQGDLNEANQDITQSVYVFPNPLQKWNWLLCHLVKFLSE 514

Human   499 GSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLD 563
            ||||:|||||.:||.::|||..:.:|..||||||||::|||||:.||:|:..:||||||||||||
  Fly   515 GSVLIFVTKKVDAETVSNNLLIKEYNCLLLHGDMDQADRNKVITQFKRKECDILVATDVAARGLD 579

Human   564 IPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKEL 628
            ||.|:.|:|||.||||:||||||||||||||||.||||:|.||..|||.||||||||:|.|..:|
  Fly   580 IPHIRNVVNYDTARDIETHTHRIGRTGRAGEKGNAYTLVTDKDKEFAGHLVRNLEGADQLVPDDL 644

Human   629 LDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNNNVMSNYEAYKP------ 687
            ::|||:::|||.||||.||||:......||||||:...|......|.:...::..|:.|
  Fly   645 MELAMKSSWFRSSRFKQGKGKRPTNTHTGLGYREKGNGGGGYGSAGGSESTASVSAHSPSDGPSS 709

Human   688 ----STGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQG 748
                |:|...||.|||:.||:|||.:.|.|:|            ...|
  Fly   710 KAFSSSGPATDRYTAMREAFRSQYNNQFRASS------------DRTW----------------- 745

Human   749 HNSPDSPVTSAAKGIPGFGNTGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERY 810
                       .|.:|..|    :..||:..||:..||.:.:::.|:|.:  .....|:.|:
  Fly   746 -----------EKTLPESG----VFAAPMAPPSSSTQGASASSANNSSNQ--DAKRAKKSRW 790

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DDX42	NP_031398.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..114		36/129 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..203		17/21 (81%)
		Q motif	253..281		20/27 (74%)
		SrmB	254..664	CDD:440279	282/409 (69%)
		DEAD box	407..410		2/2 (100%)
		dermokine	<733..>891	CDD:455732	13/78 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	737..938		13/74 (18%)
		Necessary for interaction with TP53BP2. /evidence=ECO:0000269|PubMed:19377511	738..833		13/73 (18%)
CG6418	NP_648413.1	SrmB	269..634	CDD:440279	255/364 (70%)