DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DDX42 and mahe

DIOPT Version :9

Sequence 1:	NP_031398.2	Gene:	DDX42 / 11325	HGNCID:	18676	Length:	938	Species:	Homo sapiens
Sequence 2:	NP_001284994.1	Gene:	mahe / 31707	FlyBaseID:	FBgn0029979	Length:	945	Species:	Drosophila melanogaster

Alignment Length:	895	Identity:	268/895 - (29%)
Similarity:	404/895 - (45%)	Gaps:	186/895 - (20%)

- Green bases have known domain annotations that are detailed below.

Human     9 GTKRGFGFGGFAISAGKKEEPKLPQQSHSAF----------GATSSSSGFGKSAPPQLPSFYKIG 63
            |.:.|.|.|    :||........||:..||          |.:..|.|:|             |
  Fly    81 GIQNGLGMG----AAGSGGGNPYRQQNGVAFAGNGLGGGAGGGSGGSGGYG-------------G 128

Human    64 SKRANFDEENAYFEDEEEDSSNVDLPYIPAENSPTRQQFHSKPVDSDSDDDPLEAFMAEVEDQAA 128
            .:..|                            ||..|.:.||   ::.......:.:...:.||
  Fly   129 QRGKN----------------------------PTYAQRYQKP---NNGAGVAGGYQSNNYNAAA 162

Human   129 RDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTAGVVQEEEEDNLEYDSDGNPIAPT 193
            ..|...||           |.:|:.|         .|:||...:|:.:.| |||
  Fly   163 LGMLSKEE-----------RAEIQRE---------KAKNPGRNLVKPKWE-NLE----------- 195

Human   194 KKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHF 258
                              ||.|:|||.|......:.||:.::|.:|.:.|||...|.|..||...
  Fly   196 ------------------PFLKDFYNIHPNTLAKSEQQVAEIRRELEITVSGNELPHPVVSFEES 242

Human   259 GFDEQLMHQIRKSEYTQPTPIQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEP 323
            .....::.::::..:|:||.||.||.|:||||||::|||:||||||.|::.|.::||.:|..:..
  Fly   243 SLPAHVIEEMKRQGFTKPTAIQSQGWPIALSGRDLVGIAQTGSGKTLAYMLPAIVHIGNQPPIIR 307

Human   324 GDGPIAVIVCPTRELCQQIHAECKRFGKAY--NLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGR 386
            |:||||:::.|||||.|||.:..:.:|...  .:|...::||.|...||:.|..|.|:::.||||
  Fly   308 GEGPIALVLAPTRELAQQIQSVVRDYGHLCKPEIRHTCIFGGSSKVPQARDLDRGVEVIIATPGR 372

Human   387 LIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARD 451
            |||.::.:.|||||.:|||.||||||.|||||.|:|.|...:|||||.:::|||:.|:::.||.|
  Fly   373 LIDFLENRNTNLQRCTYLVLDEADRMLDMGFEPQIRKIIEQIRPDRQVVMWSATWPKEVQALAGD 437

Human   452 ILIDPIRVVQGDIG-EANEDVTQIVEILH--SGPSKWNWLTRRLVEFTSSGS----VLLFVTKKA 509
            .|.|.|::..|.:. .||.::.|||||..  ..|.:...|...:....:||:    :::||..|.
  Fly   438 FLNDYIQINIGSMNLSANHNIRQIVEICTEIEKPQRLVCLLNEISPIKNSGNNGNKIIVFVETKI 502

Human   510 NAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYD 574
            ..|::...::.||:|...:|||..|:||:.|:.||:.....:|:|||||:||||:..::.|||||
  Fly   503 KVEDILQIIRAEGYNATSIHGDKTQNERDSVLKDFRNGKSNILIATDVASRGLDVEDLQYVINYD 567

Human   575 VARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAM---QNA 636
            .....:.:.||||||||..:.|.|||..||.::..|.:|:..||.|.|..|:.|||||.   .:.
  Fly   568 YPNSSENYVHRIGRTGRCQQLGTAYTFFTPDNAKQARELISVLEEAGQTPSQALLDLARSMPSSG 632

Human   637 WFR-KSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNNNVMSNYEA---YK-----PSTGAM 692
            .:| ..|:....|...|.||....|::|           |||.: ||:|   |.     |.||
  Fly   633 GYRGNKRWNNNSGGDRNTGGNNGIYQQR-----------NNNPL-NYQAGNNYNNNRSGPPTG-- 683

Human   693 GDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNS----PD 753
                        |.|:.:   |:..|....:.|.|...|.....:.. ...:.||..|.    |.
  Fly   684 ------------SSYQQY---AAGGNTYLQNGAGGGVNWNRMNQMGQ-DGGAGQQQRNGNTYRPR 732

Human   754 SPVTSAAK--------GIPGFGNTGNISGAP--VTYPSAGAQGVNNTASGNN----SREGTGGSN 804
            :|..:...        |..|.|....:.|.|  :..|..|.|.:.....|.:    ...|.||..
  Fly   733 APFNNGGPRAIMGHQGGGVGAGGAAGVGGGPQQLMAPQQGGQYMPQAYRGRSQFVPQGAGAGGMP 797

Human   805 GKRERYTENRGSSR---HSHGETGNRHSDSPRHGDGGRHGDGYRHPESSS 851
            .:.::|.:.....:   | :|:...:|....:..     |...:.|:..|
  Fly   798 PRFQQYPKREYQQQGVTH-YGQQALQHQQQQQQA-----GQQTKPPKDES 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DDX42	NP_031398.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..114		21/114 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..203		1/20 (5%)
		Q motif	253..281		6/27 (22%)
		PRK10590	254..688	CDD:236722	181/454 (40%)
		DEADc	255..459	CDD:238167	96/205 (47%)
		DEAD box	407..410		2/2 (100%)
		HELICc	470..601	CDD:238034	51/136 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	737..938		24/136 (18%)
		Necessary for interaction with TP53BP2. /evidence=ECO:0000269\|PubMed:19377511	738..833		21/115 (18%)
mahe	NP_001284994.1	PTZ00110	136..656	CDD:240273	207/572 (36%)
		DEADc	239..446	CDD:238167	96/206 (47%)
		HELICc	457..594	CDD:238034	51/136 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245118at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920