DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DDX42 and Ddx42

DIOPT Version :9

Sequence 1:	NP_031398.2	Gene:	DDX42 / 11325	HGNCID:	18676	Length:	938	Species:	Homo sapiens
Sequence 2:	NP_001100529.1	Gene:	Ddx42 / 303607	RGDID:	1304909	Length:	929	Species:	Rattus norvegicus

Alignment Length:	939	Identity:	893/939 - (95%)
Similarity:	908/939 - (96%)	Gaps:	11/939 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MNWNKGGPGTKRGFGFGGFAISAGKKEEPKLPQQSHSAFGATSSSSGFGKSAPPQLPSFYKIGSK 65
            ||||||||||||||||||||||||||||.||||||||||||.|||||||||||||||||||||||
  Rat     1 MNWNKGGPGTKRGFGFGGFAISAGKKEEAKLPQQSHSAFGAASSSSGFGKSAPPQLPSFYKIGSK 65

Human    66 RANFDEENAYFEDEEEDSSNVDLPYIPAENSPTRQQFHSKPVDSDSDDDPLEAFMAEVEDQAARD 130
            |||||||||||||||||||||||||||||||||||||.|||.|||||||||||||||||||||||
  Rat    66 RANFDEENAYFEDEEEDSSNVDLPYIPAENSPTRQQFRSKPADSDSDDDPLEAFMAEVEDQAARD 130

Human   131 MKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTAGVVQEEEEDNLEYDSDGNPIAPTKK 195
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||
  Rat   131 MKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTAGVVQEEEEDNLEYDSDGNPIAPSKK 195

Human   196 IIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGF 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 IIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGF 260

Human   261 DEQLMHQIRKSEYTQPTPIQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEPGD 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 DEQLMHQIRKSEYTQPTPIQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEPGD 325

Human   326 GPIAVIVCPTRELCQQIHAECKRFGKAYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDH 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   326 GPIAVIVCPTRELCQQIHAECKRFGKAYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDH 390

Human   391 VKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILID 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   391 VKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILID 455

Human   456 PIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNLKQ 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   456 PIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNLKQ 520

Human   521 EGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHR 585
            |||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||
  Rat   521 EGHNLGLLHGDMDQSERNKVILDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHR 585

Human   586 IGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKK 650
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   586 IGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKK 650

Human   651 LNIGGGGLGYRERPGLGSENMDRG-NNNVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAA 714
            ||||||||||||||||||||.||| ||||||||||||||||||||||||||||||||||||||||
  Rat   651 LNIGGGGLGYRERPGLGSENSDRGSNNNVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAA 715

Human   715 SLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGFGNTGNISGAPVTY 779
            ||||||||:|.||||||||||||||||||||||||||||:|:||:.|.||||.|:||||.|||||
  Rat   716 SLSNQKAGTSTAGASGWTSAGSLNSVPTNSAQQGHNSPDNPITSSTKNIPGFNNSGNISSAPVTY 780

Human   780 PSAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGY 844
            ||.|||||||||||:|||||.||.||||||||||||..|||||::||      ||||||||||||
  Rat   781 PSIGAQGVNNTASGSNSREGIGGGNGKRERYTENRGGGRHSHGDSGN------RHGDGGRHGDGY 839

Human   845 RHPESSSRHTDGHRHGENRHGGSAGRHGENRGANDGRNGESRKEAFNRESKMEPKMEPKVDSSKM 909
            |:|||||||||||||||.||||||.||||:||||||||||||||.||||:    :|:||||||:|
  Rat   840 RYPESSSRHTDGHRHGETRHGGSASRHGESRGANDGRNGESRKEGFNREN----RMDPKVDSSRM 900

Human   910 DKVDSKTDKTADGFAVPEPPKRKKSRWDS 938
            ||||||||||.||||||||||||||||||
  Rat   901 DKVDSKTDKTPDGFAVPEPPKRKKSRWDS 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DDX42	NP_031398.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..114		108/112 (96%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..203		19/20 (95%)
		Q motif	253..281		27/27 (100%)
		PRK10590	254..688	CDD:236722	431/434 (99%)
		DEADc	255..459	CDD:238167	203/203 (100%)
		DEAD box	407..410		2/2 (100%)
		HELICc	470..601	CDD:238034	129/130 (99%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	737..938		164/200 (82%)
		Necessary for interaction with TP53BP2. /evidence=ECO:0000269\|PubMed:19377511	738..833		73/94 (78%)
Ddx42	NP_001100529.1	PRK10590	254..678	CDD:236722	420/423 (99%)
		DEADc	255..459	CDD:238167	203/203 (100%)
		HELICc	470..601	CDD:238034	129/130 (99%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83690668
Domainoid	1	1.000	626	1.000	Domainoid score	I4473
eggNOG	1	0.900	-	-		E2759_KOG0339
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49137
Inparanoid	1	1.050	1810	1.000	Inparanoid score	I1844
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG46804
OrthoDB	1	1.010	-	-		D109869at7742
OrthoFinder	1	1.000	-	-		FOG0005388
OrthoInspector	1	1.000	-	-		oto130370
orthoMCL	1	0.900	-	-		OOG6_104858
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3817
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270