Protein Alignment KIF12 and klp8

DIOPT Version :10

• Sequence 1: XP_005251740.1
• Gene: KIF12 / 113220
• HGNCID: 21495
• Length: 669
• Species: Homo sapiens
• Sequence 2: NP_594675.1
• Gene: klp8 / 2542849
• PomBaseID: SPAC144.14
• Length: 511
• Species: Schizosaccharomyces pombe
• Alignment Length: 483
• Identity: 118/483 - (24%)
• Similarity: 200/483 - (41%)
• Gaps: 111/483 - (22%)

Human    26 IQVVLRVRPMSAAELRRGQQSVLHC-SGTRTLQVSPPGGGPEVAFRFGAVLDAART--------- 80
            ::|::||||.|..||.:..:.:|.. |..:|:.::||..|.:.: |....::..||
pombe     6 VRVIVRVRPKSLRELSKSAEDLLSVDSHNKTVTITPPKHGLKHS-RHKNRVNGPRTFAFDECFAP 69

Human    81 ----------QEDVFRACGVRRLGELALRGFSCTVFTFGQTGSGKTYTLTGPPPQGEGVPVPPSL 135
                      ||||:.:.| ..|.:..|.||:....|:||.|:||||::.|.    .|.|
pombe    70 SAPESKNLSGQEDVYESTG-PLLVKSILEGFNSCFITYGQKGTGKTYSVVGL----RGQP----- 124

Human   136 AGIMQRTFAWLLDRVQHL-----GAPVTLRASYLEIYNEQVRDLL-----SLGSP-RPLPVRWNK 189
             ||:......:.:.:..|     ...:|:..|..||..|...|||     |..:| ..:.|:.:.
pombe   125 -GIIPHISESIFEEIDKLKKKSPNTTITVSISLAEIIEETPYDLLQPNVNSSHTPGETVFVQKDS 188

Human   190 TRGFYVEQLRVVEFGSLEALMELLQTGLSRRRNSAHTLNQASSRSHALLTLYISRQTAQQMPSVD 254
            ..|:::..|...|.||.:.:...|:......|.....:: ...:.|::.:|.:      |...:|
pombe   189 LTGYHLHGLSEFEVGSAQEIDAFLRLAAKNIRTELSDIS-GVRKGHSVFSLVV------QQRIID 246

Human   255 P---GEPPVGGKLCFVDLA----GSEKVAATGSRGELMLEANSINRSLLALGHCISLLLDPQRKQ 312
            |   .......:|..:|||    ||::..:..|     .|::|.|:||..|...|:.|.. ::..
pombe   247 PKTRHSLKKASRLQIIDLASFSKGSQRNESISS-----FESSSNNKSLSVLNRVIAALTS-KKND 305

Human   313 SHIPFRDSKLTKLLADSLGGRGVTLMVACVSPSAQC-LPETLSTLRYASRAQRVTTRPQAPKSPV 376
            ..||::||.||.||.|:|||...|:|:.||||   | ..:|.|.|||:..|:|:.
pombe   306 VLIPYKDSVLTTLLQDALGGNCRTIMLTCVSP---CDFDDTFSALRYSEAARRIK---------- 357

Human   377 AKQPQRLETEMLQLQEENRRLQFQLDQMDCKASGLSGARVAWAQRN---LYGMLQEFMLENERLR 438
                                   .:..::||.        |::..|   |..:|.....:.|:||
pombe   358 -----------------------NISNINCKE--------AYSTNNEGELDDILTTLESDREQLR 391

Human   439 KEKSQLQNSRDLAQNEQRILAQQVHALE 466
            :.:...|......:..:....:::||||
pombe   392 RHEEHSQKLLKFIEEIRNDYEERIHALE 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF12	XP_005251740.1	KISc	25..363	CDD:276812	102/375 (27%)
		YhaN	<381..>472	CDD:443752	14/89 (16%)
klp8	NP_594675.1	KISc	5..354	CDD:276812	102/375 (27%)