Protein Alignment KIF12 and kif18b

DIOPT Version :9

• Sequence 1: XP_005251740.1
• Gene: KIF12 / 113220
• HGNCID: 21495
• Length: 669
• Species: Homo sapiens
• Sequence 2: XP_002939283.3
• Gene: kif18b / 100490953
• XenbaseID: XB-GENE-5960389
• Length: 872
• Species: Xenopus tropicalis
• Alignment Length: 732
• Identity: 199/732 - (27%)
• Similarity: 302/732 - (41%)
• Gaps: 159/732 - (21%)

Human    12 ARSLEQGPEGPETPIQVVLRVRPMSAAELRRGQQSVLHCSGTRTLQVSPP-------------GG 63
            |.|.|:|      .:.||:||||.:..|......:|:.......|...|.             ..
 Frog     5 ASSTEEG------NVSVVVRVRPPNQREQEGNHHAVVQVVDHNMLVFDPDEPETTGVFSSLRGND 63

Human    64 GP-----EVAFRFGAVLDAARTQEDVFRACGVRRLGELALRGFSCTVFTFGQTGSGKTYTLTGPP 123
            ||     ::.|.|..:......|:|||... .:.:.:..|.|::|:||.:|.||:|||:|:.|
 Frog    64 GPKRKGKDMKFIFDRIFGENSRQQDVFEHT-TKEILDGVLNGYNCSVFAYGATGAGKTHTMLG-- 125

Human   124 PQGEGVPVPPSLAGIMQRTFAWLLDRVQHLGAPVTLRA--SYLEIYNEQVRDLLSLGSPR-PLPV 185
              .|..|      |:|..|...|..|::.:....:...  ||||:||||::|||   .|| .|.:
 Frog   126 --SEADP------GVMYLTMVELYRRIEAIKEEKSCEVLISYLEVYNEQIQDLL---EPRGSLAI 179

Human   186 RWNKTRGFYVEQLRVVEFGSLEALMELLQTGLSRRRNSAHTLNQASSRSHALLTLYISRQTAQQM 250
            |.:..:|..|:.|...:..|.:.|:::|.:|...|.......|.:||.|||:..:|:.    ||.
 Frog   180 REDPQKGVVVQGLSFHQPKSADQLLQMLASGNLNRTQHPTDANASSSHSHAVFQIYVK----QQD 240

Human   251 PSVDPGEPPVGGKLCFVDLAGSEKVAATGSRGELMLEANSINRSLLALGHCISLLLDPQRKQSHI 315
            .:|...:.....|:..:||||||:.:.|.::||.:.|..:||||||||.:.|:.|.|.:.|::||
 Frog   241 RTVSISQDVRVAKMSLIDLAGSERASTTNAKGERLREGANINRSLLALINVINALADAKSKKAHI 305

Human   316 PFRDSKLTKLLADSLGGRGVTLMVACVSPSAQCLPETLSTLRYASRAQRVTTRPQAPKSPV---- 376
            |:||||||:||.||:||...|:|:|.:||||....:|.:||:||:||:.:..   :.||.|
 Frog   306 PYRDSKLTRLLKDSIGGNCRTVMIAAISPSALSYDDTYNTLKYANRAKEIKL---SMKSNVINLD 367

Human   377 ------AKQPQRLETEMLQLQEENRRLQFQLDQMDCKASGLSGARVAWAQRNLYGMLQEFMLENE 435
                  |...:.|:.|:.:|:|:.|..:.: :|.|...|                       :|.
 Frog   368 CHISKYAAVCEELKAEVAELREKLRFYEMK-EQPDDDTS-----------------------DNS 408

Human   436 RLRKEKSQLQNSRDLAQNEQRILAQQVHALERRLLSACYHHQQGPGLTPPCPCLMAPAPPCHALP 500
            ...|...:.:...||...||...|..:..      |:|......|....|......|........
 Frog   409 LQDKTSPRREEHSDLGSPEQGSGALLLST------SSCQSQDHKPAEMNPRKWDQVPLNCSLGRE 467

Human   501 PLYSCPCCH------------------ICPLCRV-PLAHWACLPGEHHLPQVLDPEASGGRPPSA 546
            .|...||.|                  :...|.: .||.......|..|.| |:..|..|:..:|
 Frog   468 ELEKNPCLHEALKDDAAERLVTSLLNFVRKQCEILKLAGLYTPELEDELRQ-LEGLALRGQKATA 531

Human   547 RPPPWAPPCSPGSAKCPRERSHSDWTQTRVLAEMLT--EEEVVPSAPPL--------------PV 595
                               ...::..|.....||.|  |:|.||..|.:              ||
 Frog   532 -------------------EKVTEKEQVTEEHEMETHKEQEEVPQTPLVEDVVFDIKEEVIEDPV 577

Human   596 RPP-KTSPGLR-GASACPDVGPGFQT--WPRDWR------PSETRLAAPCDVAAASHPAVRAHGA 650
            .|. |..||.| .|...||..|..::  .|...|      |::.|||     ...|.|.|:....
 Frog   578 PPARKRKPGKRYRADILPDNSPSLRSPIVPVKRRREATNTPTKARLA-----GVPSTPEVQVKRP 637

Human   651 QAKSSLPIEGQVGTQET 667
            : |||:|...:|..:.:
 Frog   638 R-KSSIPSRCRVSLRSS 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF12	XP_005251740.1	KISc	25..363	CDD:276812	122/358 (34%)
		Kinesin	31..365	CDD:278646	121/354 (34%)
		Kinesin-relat_1	<383..469	CDD:289481	15/85 (18%)
kif18b	XP_002939283.3	KISc_KIP3_like	23..355	CDD:276821	117/349 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910