DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GPN1 and CG3704

DIOPT Version :9

Sequence 1:	NP_009197.3	Gene:	GPN1 / 11321	HGNCID:	17030	Length:	374	Species:	Homo sapiens
Sequence 2:	NP_569872.1	Gene:	CG3704 / 31043	FlyBaseID:	FBgn0040346	Length:	382	Species:	Drosophila melanogaster

Alignment Length:	387	Identity:	187/387 - (48%)
Similarity:	251/387 - (64%)	Gaps:	31/387 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAASAAAAELQA---SGGPRH-PVCLLVLGMAGSGKTTFVQRLTGHLHAQGTPPYVINLDPAVHE 61
            ||....:.:|:|   |.|.|. |||:|||||||||||||.|:|..|...:.. |||:|||||..|
  Fly     1 MAEGVESIKLEALSLSEGIRESPVCILVLGMAGSGKTTFTQKLIQHAQEKFN-PYVVNLDPACRE 64

Human    62 VPFPANIDIRDTVKYKEVMKQYGLGPNGGIVTSLNLFATRFDQVMKFIEKA-QNMSKYVLIDTPG 125
            ||:.|::||||||.|:||||||.|||||||||:||:|.|:..|..:.:.:| :...|:.:|||||
  Fly    65 VPYAAHVDIRDTVNYREVMKQYQLGPNGGIVTALNMFTTKMAQFAELVRRAGERGHKWCVIDTPG 129

Human   126 QIEVFTWSASGTIITEALASSFPTVVIYVMDTSRSTNPVTFMSNMLYACSILYKTKLPFIVVMNK 190
            |||||.|||||:||||.||:.|||:|:||||..||..|.||||||||||||||||:|||:|.:||
  Fly   130 QIEVFNWSASGSIITEGLATMFPTIVVYVMDVERSACPTTFMSNMLYACSILYKTRLPFLVALNK 194

Human   191 TDIIDHSFAVEWMQDFEAFQDALNQETTYVSNLTRSMSLVLDEFYSSLRVVGVSAVLGTGLDELF 255
            .|:.|..|.::||.||||||:|..:|.::||||||:|||.||.||.:||..||||..|.|..:|.
  Fly   195 IDLKDCGFVMDWMTDFEAFQEAQEEEHSFVSNLTRTMSLTLDTFYENLRTCGVSAKTGVGFTQLL 259

Human   256 VQVTSAAEEYEREYRPEYERLKKSLANAESQQQREQLERLRKDMGSVAL---------DAGTAKD 311
            .::..:.:|||.:|:|.||: |:....|||....:.::.:.:|..:|.|         ..|.:..
  Fly   260 TKILESVDEYETDYKPVYEK-KRQERLAESATGPKPVDHVEEDGHAVPLGLSLQDPPPHTGNSIF 323

Human   312 SLSPVLHPSDLILTRGTLDEEDEEADSDTDDIDHRVTEESHEEPAFQNFMQESM-AQYWKRN 372
            .::|.|.|....:      |::||.:.|        .:.:.||..|.:|:|..: ||..||:
  Fly   324 LMAPSLVPESAEI------EDEEEMEED--------AKGTAEEQNFHSFVQNHLTAQQSKRD 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPN1	NP_009197.3	ATP_bind_1	24..261	CDD:308588	145/237 (61%)
		Gly-Pro-Asn (GPN)-loop, involved in dimer interface. /evidence=ECO:0000250\|UniProtKB:Q9UYR9	86..88		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	326..354		4/27 (15%)
CG3704	NP_569872.1	Gem1	24..199	CDD:224025	114/175 (65%)
CG3704	NP_569872.1	ATP_bind_1	28..268	CDD:281079	145/240 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160333
Domainoid	1	1.000	296	1.000	Domainoid score	I1478
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5257
Inparanoid	1	1.050	336	1.000	Inparanoid score	I2406
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54774
OrthoDB	1	1.010	-	-		D1096688at2759
OrthoFinder	1	1.000	-	-		FOG0005260
OrthoInspector	1	1.000	-	-		oto91719
orthoMCL	1	0.900	-	-		OOG6_101544
Panther	1	1.100	-	-	LDO	PTHR21231
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R835
SonicParanoid	1	1.000	-	-		X3783
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940