Protein Alignment CHRM4 and Octbeta1R

DIOPT Version :10

• Sequence 1: NP_000732.2
• Gene: CHRM4 / 1132
• HGNCID: 1953
• Length: 479
• Species: Homo sapiens
• Sequence 2: NP_651057.1
• Gene: Octbeta1R / 42652
• FlyBaseID: FBgn0038980
• Length: 508
• Species: Drosophila melanogaster
• Alignment Length: 463
• Identity: 111/463 - (23%)
• Similarity: 186/463 - (40%)
• Gaps: 158/463 - (34%)

Human    22 SSHNRYETVEMVFI-ATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFS 85
            |||     :.:||: ..:.|.:.|..::||:||::|:..:|:|:.:.|||:.|||.||:::...:
  Fly   101 SSH-----LALVFVKCFIIGFIILAAILGNMLVIVSVMRHRKLRIITNYFVVSLAVADMLVALCA 160

Human    86 MNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAG 150
            |......:|.|.|..|:|:||:|.:.|...|.||:|:|..||.|||:.:.:||.||...|.:...
  Fly   161 MTFNASVMISGKWMFGSVMCDMWNSFDVYFSTASIMHLCCISVDRYYAIVQPLDYPLIMTQRRVF 225

Human   151 LMIAAAWVLSFVLWAPAIL-FWQFVVGKRTVPDNQCFI-------QFLSNPAVTFGTAIAAFYLP 207
            :|:...|:      :||:| |.....|..|..:|..::       :|..|.|....::..:|::|
  Fly   226 IMLLMVWL------SPALLSFLPICSGWYTTTENYKYLKSNPHICEFKVNKAYAIVSSSMSFWIP 284

Human   208 VVIMTVLYIHISLASRSRVHKHRPEGPKEK---KAKTLAFLKSPLMKQSVKKPPPGEAAREELRN 269
            .::|..:|..|          ::....:|:   ::|..|.|
  Fly   285 GIVMLSMYYRI----------YQEADRQERLVYRSKVAALL------------------------ 315

Human   270 GKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALN 334
              ||:....:..|.|||
  Fly   316 --LEKHLQISQIPKPRP------------------------------------------------ 330

Human   335 PASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVT 399
                                 :|::..:|.:.||                         ||||..
  Fly   331 ---------------------SIQVEQSTISTMR-------------------------RERKAA 349

Human   400 RTIFAILLAFILTWTPYNVMVLVNTFCQSCI-PDTVWSIGYWLCYVNSTINPACYALCN----AT 459
            ||:..|:.||::.|.|:.:..:|::.|.||| |..:..|.:|:.|.||.:||..||..|    |.
  Fly   350 RTLGIIMSAFLICWLPFFLWYIVSSLCDSCITPRLLVGILFWIGYFNSALNPIIYAYFNRDFRAA 414

Human   460 FKKTFRHL 467
            ||||.:.|
  Fly   415 FKKTLKSL 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHRM4	NP_000732.2	7tmA_mAChR_M4	33..464	CDD:341344	106/447 (24%)
		TM helix 1	34..60	CDD:341344	8/26 (31%)
		TM helix 2	67..93	CDD:341344	9/25 (36%)
		TM helix 3	105..135	CDD:341344	14/29 (48%)
		TM helix 4	147..170	CDD:341344	5/23 (22%)
		TM helix 5	192..221	CDD:341344	7/28 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..333		6/61 (10%)
		TM helix 6	393..423	CDD:341344	11/29 (38%)
		TM helix 7	432..457	CDD:341344	9/24 (38%)
Octbeta1R	NP_651057.1	7tmA_DmOct-betaAR-like	109..415	CDD:320194	101/441 (23%)
		TM helix 1	109..135	CDD:320194	7/25 (28%)
		TM helix 2	142..168	CDD:320194	9/25 (36%)
		TM helix 3	180..210	CDD:320194	14/29 (48%)
		TM helix 4	222..245	CDD:320194	6/28 (21%)
		TM helix 5	269..298	CDD:320194	7/38 (18%)
		TM helix 6	343..373	CDD:320194	12/54 (22%)
		TM helix 7	383..408	CDD:320194	9/24 (38%)