DRSC/TRiP Functional Genomics Resources

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Protein Alignment CHRM4 and mAChR-B

DIOPT Version :10

Sequence 1:NP_000732.2 Gene:CHRM4 / 1132 HGNCID:1953 Length:479 Species:Homo sapiens
Sequence 2:NP_649764.1 Gene:mAChR-B / 40955 FlyBaseID:FBgn0037546 Length:1019 Species:Drosophila melanogaster


Alignment Length:895 Identity:164/895 - (18%)
Similarity:246/895 - (27%) Gaps:471/895 - (52%)


- Green bases have known domain annotations that are detailed below.


Human    31 EMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIK 95
            :.:.||.......::||.|||||:|:..|:|.::..:|||:.|||..|::||..||..||:|::|
  Fly   132 QTILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATDMLIGTVSMPFYTIYVLK 196

Human    96 GYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLS 160
            |||.||.::|||||::||.|...|...:|:|:.|||..|.....|.:.||......|:...|::.
  Fly   197 GYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSWRTRTRVIYMVTITWIIP 261

Human   161 FVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHI-----SL 220
            .:|:..:|..|:...|||.:...||.:|||.:|.......|..::..::::.|||..|     .:
  Fly   262 ALLFFISIFGWEHFTGKRDLLPGQCAVQFLKDPIFNTALIIGYYWTTLIVLFVLYAGIYKTAYDM 326

Human   221 ASRS------------------------------------------------------------- 224
            ..||                                                             
  Fly   327 QKRSEAKQRKMQSMVALSAGAMSGMAGHAAGIGVIEEKILKTKVELAGDQTDLDSACTTVIKRLS 391

Human   225 -------------RVHKHRPE---------------------GPKEKKAKTLAF----------- 244
                         .|.|..||                     ..|.:::.:.||           
  Fly   392 GSGQANPLAVATEEVEKMTPEQRRASAAKIQEEAKKREAAVDAEKSERSSSPAFDSDEESSVNQA 456

Human   245 -------------------------------------------------------------LKSP 248
                                                                         .:||
  Fly   457 QQLITQQKLNNMRKRSSIGLVFGAQAALLATRGKGNLQKSTTNSKSIEAMHQYHHHQQHHHNQSP 521

Human   249 LMKQSVKK----------------------------------------------------PP--- 258
            |.:...|:                                                    ||   
  Fly   522 LQRAQSKEEMRSLHHHQNQQQPHHQHHQNQPNPPLDRPKRTSCSTLSQIAEHDRLVDLSAPPTLL 586

Human   259 ------------PGEAAREELRNGKLE-------------------------------------- 273
                        |.|...:::..|.::                                      
  Fly   587 NTSDPLSPVDLAPIEVPSDQVHQGLVQTILPPPDAFQCPTPLSDDYSDRPFGNSSGNSELALTYD 651

Human   274 --------------------------------EAPPPALPPPPRPVADKDTSNESSSGSATQNTK 306
                                            :..||.|||||....:...||.:.|.|.|.:..
  Fly   652 LMTNSELRYMDESSAMLASVTANSTTSPNDSVQGKPPVLPPPPPARRNPPKSNLNQSLSQTPSQN 716

Human   307 ERPATELSTT------------------------------------------------------- 316
            :.|:..||..                                                       
  Fly   717 QSPSQSLSLNLNPNHNQSQSQSIEEAVAIEKRLLVSYTGIEDFAKVRRESCIEAICLLDVPGKLA 781

Human   317 ------EATTP-------AMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMR 368
                  .|::|       |:...|:.|..|:|     |::..|.|||         .|.:.||:.
  Fly   782 ADCPHRRASSPMETSSKDAILYSPMPPMPLSP-----KVKTSTPQTG---------TPQSAAGVT 832

Human   369 PA----------------------------------------------------ANVARKFASIA 381
            |.                                                    ||...|..:.:
  Fly   833 PPVPLERIEERETSDSNTNKMPSTSGTTSSTGGVGGGGEQDGVGATKKNAGDDDANREEKSLAAS 897

Human   382 RNQV--------------------------RKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV 420
            ||..                          |:|.:...|.||..|||..||..|:..||||:|:.
  Fly   898 RNSSKRAFIHSIGKHFKSKKALPLILGVGGRQKSKSENRARKAFRTISFILGCFVACWTPYHVLA 962

Human   421 LVNTFCQ--SCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLL 468
            ||..||:  .||.:.::...|:|||.||.:||.||||.|..|||||..:|
  Fly   963 LVEGFCRHPPCINEHLYMFSYFLCYANSPMNPFCYALANQQFKKTFTRIL 1012

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CHRM4NP_000732.2 7tmA_mAChR_M4 33..464 CDD:341344 161/887 (18%)
TM helix 1 34..60 CDD:341344 10/25 (40%)
TM helix 2 67..93 CDD:341344 13/25 (52%)
TM helix 3 105..135 CDD:341344 14/29 (48%)
TM helix 4 147..170 CDD:341344 4/22 (18%)
TM helix 5 192..221 CDD:341344 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 271..333 20/199 (10%)
TM helix 6 393..423 CDD:341344 15/29 (52%)
TM helix 7 432..457 CDD:341344 12/24 (50%)
mAChR-BNP_649764.1 7tmA_mAChR_GAR-2-like 147..>323 CDD:320429 67/175 (38%)
TM helix 2 168..194 CDD:320429 13/25 (52%)
TM helix 3 206..236 CDD:320429 14/29 (48%)
TM helix 4 248..271 CDD:320429 4/22 (18%)
TM helix 5 293..322 CDD:320429 6/28 (21%)
7tm_GPCRs <932..1008 CDD:475119 36/75 (48%)
TM helix 6 941..963 CDD:410628 11/21 (52%)
TM helix 7 976..1001 CDD:410628 12/24 (50%)

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