DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PARK7 and DJ-1alpha

DIOPT Version :9

Sequence 1:	NP_001116849.1	Gene:	PARK7 / 11315	HGNCID:	16369	Length:	189	Species:	Homo sapiens
Sequence 2:	NP_610916.1	Gene:	DJ-1alpha / 36543	FlyBaseID:	FBgn0033885	Length:	217	Species:	Drosophila melanogaster

Alignment Length:	185	Identity:	104/185 - (56%)
Similarity:	129/185 - (69%)	Gaps:	4/185 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     3 SKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPY 67
            :|.||:|||.||||||..|..||:||..|.||||||...:||:|||.|||.||.|||:|...|.|
  Fly    30 AKNALIILAPGAEEMEFTISADVLRRGKILVTVAGLHDCEPVKCSRSVVIVPDTSLEEAVTRGDY 94

Human    68 DVVVLPGGNLGAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDK 132
            ||||||||..|.:.|..|:||.::|:.||::.||||||||.||||..|.||.|..:|:||..|.:
  Fly    95 DVVVLPGGLAGNKALMNSSAVGDVLRCQESKGGLIAAICAAPTALAKHGIGKGKSITSHPDMKPQ 159

Human   133 MMNGGHYTYSENR-VEKDGLILTSRGPGTSFEFALAIVEALNGKEVAAQV-KAPL 185
            :..  .|.|.::: |.:||.|:|||||||:|:|||.|.|.|.|.|||.:| ||.|
  Fly   160 LKE--LYCYIDDKTVVQDGNIITSRGPGTTFDFALKITEQLVGAEVAKEVAKAML 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PARK7	NP_001116849.1	not_thiJ	5..184	CDD:213612	101/180 (56%)
DJ-1alpha	NP_610916.1	ThiJ	33..210	CDD:333423	100/178 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147888
Domainoid	1	1.000	171	1.000	Domainoid score	I3745
eggNOG	1	0.900	-	-		E1_COG0693
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38295
Inparanoid	1	1.050	181	1.000	Inparanoid score	I3996
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54253
OrthoDB	1	1.010	-	-		D1165707at2759
OrthoFinder	1	1.000	-	-		FOG0002774
OrthoInspector	1	1.000	-	-		otm42153
orthoMCL	1	0.900	-	-		OOG6_101257
Panther	1	1.100	-	-	O	PTHR48094
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1763
SonicParanoid	1	1.000	-	-		X2164
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800