Protein Alignment VPS45 and Vps45

DIOPT Version :10

• Sequence 1: NP_009190.2
• Gene: VPS45 / 11311
• HGNCID: 14579
• Length: 570
• Species: Homo sapiens
• Sequence 2: NP_649909.1
• Gene: Vps45 / 41153
• FlyBaseID: FBgn0261049
• Length: 574
• Species: Drosophila melanogaster
• Alignment Length: 570
• Identity: 308/570 - (54%)
• Similarity: 421/570 - (73%)
• Gaps: 20/570 - (3%)

Human     1 MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFERIDS-QNREIMK 64
            ||::..:|.||.||..:||||||::|:|||||.|:||.::||::||:|||||||:|| ::.|.:|
  Fly     1 MNLISGIKLYIEKMCSESGPGMKIILLDKETTSIISMAFSQSDMLQREVYLFERLDSGRSNERLK 65

Human    65 HLKAICFLRPTKENVDYIIQELRRPKYTIYFIYFSNVISKSDVKSLAEADEQEVVAEVQEFYGDY 129
            :||.|.|:||||:|:..:..|||.|||:.|:|||||:|.::|:|.|||.||.|.|.||:|.|.||
  Fly    66 YLKCIVFIRPTKQNIQLLANELRNPKYSAYYIYFSNIIPRTDIKYLAECDESESVREVKELYADY 130

Human   130 IAVNPHLFSLNILGCCQGRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLSSEAAKRLAECVKQV 194
            :.|||:||||.|..|....||.|..|:|:.||:||:|||||..|:|||:..|:||:.||:.:.:.
  Fly   131 LCVNPNLFSLGIPNCMANLNWLPDALNRSMQGITAVLLSLKLNPVIRYRAGSQAAQLLAKLIYEQ 195

Human   195 ITKEYELFEFRRT---EVPPLLLILDRCDDAITPLLNQWTYQAMVHELLGINNNRIDLSRVPGIS 256
            ||||..||:||..   ..|||||:|||.||.:||||:||||||||||||.|.|||:|||..|.:.
  Fly   196 ITKESSLFDFRSNMDGAAPPLLLVLDRRDDPVTPLLHQWTYQAMVHELLHIKNNRLDLSNCPNVP 260

Human   257 KDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKKPKEQQKLESIADMKAFVENYPQF 321
            ||.:|:|||.:.|:||.||||.|:.||||.||.|||:|| :|..:.:|:|||||||.|:|:||||
  Fly   261 KDFKELVLSGDQDDFYGNNMYANYGEIGSTIKQLMEEFQ-RKANDHKKVESIADMKNFIESYPQF 324

Human   322 KKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQNDHSSALQNIKRLLQNPKVTEFDAAR 386
            |||||||.||:.|:||||.|.::|||.||||:|||:||:.:||:.||.||:|:.:.:|:..||.:
  Fly   325 KKMSGTVQKHLCVIGELSALSNKRNLFEVSELEQEIACKAEHSAQLQRIKKLIADERVSIDDALK 389

Human   387 LVMLYALHYERHSSNSLPGLMMDLRNKGVSEKYRKLVSAVVEYGGKRVRGSDLFSP---KDAVAI 448
            ||.||||.||||::....||:..::.:|   ....:|.:::||.|..||..|||:.   .|||.:
  Fly   390 LVALYALRYERHANCDTSGLLQIIKTRG---GRAAIVPSLIEYAGTHVRQGDLFNMVRITDAVKL 451

Human   449 TKQFLKGLKGVENVYTQHQPFLHETLDHLIKGRLKENLYPYLGPSTL--RDRPQDIIVFVIGGAT 511
            |:..:|||||||||:|||.|.|.|||:.:.|||..:.|:|.:....:  |..||:::||:|||||
  Fly   452 TRNLIKGLKGVENVFTQHTPLLKETLEDVFKGRELDPLFPAINSELVPFRRPPQEVVVFIIGGAT 516

Human   512 YEEALTVYNLNRTTPGVRIVLGGTTVHNTKSFLEEVLA--SGL---HSRS 556
            |||||.|:.||..  |.:::|||||:||::||::||:|  ||:   |::|
  Fly   517 YEEALAVHQLNNA--GYKVILGGTTIHNSQSFIQEVVAATSGIQFKHTKS 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VPS45	NP_009190.2	Sec1	23..546	CDD:460020	289/531 (54%)
Vps45	NP_649909.1	Sec1	23..549	CDD:460020	289/531 (54%)