DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VPS45 and Vps45

DIOPT Version :9

Sequence 1:	NP_009190.2	Gene:	VPS45 / 11311	HGNCID:	14579	Length:	570	Species:	Homo sapiens
Sequence 2:	NP_649909.1	Gene:	Vps45 / 41153	FlyBaseID:	FBgn0261049	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	570	Identity:	308/570 - (54%)
Similarity:	421/570 - (73%)	Gaps:	20/570 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFERIDS-QNREIMK 64
            ||::..:|.||.||..:||||||::|:|||||.|:||.::||::||:|||||||:|| ::.|.:|
  Fly     1 MNLISGIKLYIEKMCSESGPGMKIILLDKETTSIISMAFSQSDMLQREVYLFERLDSGRSNERLK 65

Human    65 HLKAICFLRPTKENVDYIIQELRRPKYTIYFIYFSNVISKSDVKSLAEADEQEVVAEVQEFYGDY 129
            :||.|.|:||||:|:..:..|||.|||:.|:|||||:|.::|:|.|||.||.|.|.||:|.|.||
  Fly    66 YLKCIVFIRPTKQNIQLLANELRNPKYSAYYIYFSNIIPRTDIKYLAECDESESVREVKELYADY 130

Human   130 IAVNPHLFSLNILGCCQGRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLSSEAAKRLAECVKQV 194
            :.|||:||||.|..|....||.|..|:|:.||:||:|||||..|:|||:..|:||:.||:.:.:.
  Fly   131 LCVNPNLFSLGIPNCMANLNWLPDALNRSMQGITAVLLSLKLNPVIRYRAGSQAAQLLAKLIYEQ 195

Human   195 ITKEYELFEFRRT---EVPPLLLILDRCDDAITPLLNQWTYQAMVHELLGINNNRIDLSRVPGIS 256
            ||||..||:||..   ..|||||:|||.||.:||||:||||||||||||.|.|||:|||..|.:.
  Fly   196 ITKESSLFDFRSNMDGAAPPLLLVLDRRDDPVTPLLHQWTYQAMVHELLHIKNNRLDLSNCPNVP 260

Human   257 KDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKKPKEQQKLESIADMKAFVENYPQF 321
            ||.:|:|||.:.|:||.||||.|:.||||.||.|||:|| :|..:.:|:|||||||.|:|:||||
  Fly   261 KDFKELVLSGDQDDFYGNNMYANYGEIGSTIKQLMEEFQ-RKANDHKKVESIADMKNFIESYPQF 324

Human   322 KKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQNDHSSALQNIKRLLQNPKVTEFDAAR 386
            |||||||.||:.|:||||.|.::|||.||||:|||:||:.:||:.||.||:|:.:.:|:..||.:
  Fly   325 KKMSGTVQKHLCVIGELSALSNKRNLFEVSELEQEIACKAEHSAQLQRIKKLIADERVSIDDALK 389

Human   387 LVMLYALHYERHSSNSLPGLMMDLRNKGVSEKYRKLVSAVVEYGGKRVRGSDLFSP---KDAVAI 448
            ||.||||.||||::....||:..::.:|   ....:|.:::||.|..||..|||:.   .|||.:
  Fly   390 LVALYALRYERHANCDTSGLLQIIKTRG---GRAAIVPSLIEYAGTHVRQGDLFNMVRITDAVKL 451

Human   449 TKQFLKGLKGVENVYTQHQPFLHETLDHLIKGRLKENLYPYLGPSTL--RDRPQDIIVFVIGGAT 511
            |:..:|||||||||:|||.|.|.|||:.:.|||..:.|:|.:....:  |..||:::||:|||||
  Fly   452 TRNLIKGLKGVENVFTQHTPLLKETLEDVFKGRELDPLFPAINSELVPFRRPPQEVVVFIIGGAT 516

Human   512 YEEALTVYNLNRTTPGVRIVLGGTTVHNTKSFLEEVLA--SGL---HSRS 556
            |||||.|:.||..  |.:::|||||:||::||::||:|  ||:   |::|
  Fly   517 YEEALAVHQLNNA--GYKVILGGTTIHNSQSFIQEVVAATSGIQFKHTKS 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VPS45	NP_009190.2	Sec1	23..539	CDD:307231	285/524 (54%)
Vps45	NP_649909.1	Sec1	23..543	CDD:279352	286/525 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157028
Domainoid	1	1.000	577	1.000	Domainoid score	I218
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5250
Inparanoid	1	1.050	608	1.000	Inparanoid score	I930
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53693
OrthoDB	1	1.010	-	-		D311758at33208
OrthoFinder	1	1.000	-	-		FOG0005111
OrthoInspector	1	1.000	-	-		oto88478
orthoMCL	1	0.900	-	-		OOG6_101522
Panther	1	1.100	-	-	LDO	PTHR11679
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1689
SonicParanoid	1	1.000	-	-		X3630
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940