DRSC/TRiP Functional Genomics Resources

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Protein Alignment CHRM3 and TyrR

DIOPT Version :10

Sequence 1:NP_000731.1 Gene:CHRM3 / 1131 HGNCID:1952 Length:590 Species:Homo sapiens
Sequence 2:NP_650652.1 Gene:TyrR / 42136 FlyBaseID:FBgn0038542 Length:631 Species:Drosophila melanogaster


Alignment Length:619 Identity:156/619 - (25%)
Similarity:248/619 - (40%) Gaps:156/619 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    30 PPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGH-----TVWQVVFIAFLTGILALVTIIGNILV 89
            |...||.|..||.|.||..::            |     ..||.:.:..:.....:||:|||.||
  Fly    85 PTAPVTTFNYYNESAAAAEWA------------HFYDLVLSWQGIILIAVFATFIVVTVIGNTLV 137

Human    90 IVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNA 154
            |::....::|:|:.|.|::|||.|||::|:..|.......::..|.||.:.||:|:::|.:...|
  Fly   138 ILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGSWQLGWVLCDIWISLDVLLCTA 202

Human   155 SVMNLLVISFDRYFSITRPLTYRAKRTTKR-AGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPP 218
            |:::|..||.|||.::||||||..||.:|| |.:||.:.|:::..:..|.:|.| |..|:|.:  
  Fly   203 SILSLCAISVDRYLAVTRPLTYSRKRRSKRLALIMILIVWLLALAITCPPMLGW-YEPGRRDL-- 264

Human   219 GEC-FIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASG------TEAE 276
            .|| :.|  :|..:.| :|:.:|::|:.:|..:|.||......|...:..:....      |.|:
  Fly   265 RECRYNQ--NEGYVIF-SAMGSFFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAAD 326

Human   277 TENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNND 341
            .||              ||.:|.                     :.||....|..::|.:::|..
  Fly   327 VEN--------------ELSEQE---------------------QHSSVGQRQRQATSRTFSNQT 356

Human   342 AAASLENSASSDEED---------------IGSETRAIY-SIVLKLP----GHS----------- 375
            .|..|::...||.::               ..|.|...: ..:|.||    |.|           
  Fly   357 IAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGCAKNGCYEL 421

Human   376 TILNSTKLPSSDNLQVPEEELGMVDLERKAD-KLQAQKSVDDGGSFPKSFSKLP----------- 428
            |..:|.|..|:.:..:.....||.......| :.|:|.....|.....|.|:.|           
  Fly   422 TRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTHSFRHSHGE 486

Human   429 --------------IQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRK 479
                          ...::.|.|..||      |.::|                 .|.|:....:
  Fly   487 RDRERLRSHHHHPHYHHQAGVTTTSTS------GNTSA-----------------NTNSKSLSNR 528

Human   480 RMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTF-----CDSCIPKTFWNLGYWLCYINSTV 539
            ..||.||.|..||||.::..||..|.|:.|..|:..|     ....:.|..    .||.:.||.:
  Fly   529 ITSLKKENKTTQTLSIVVGGFIACWLPFFINYLITPFLAEHQASQMLAKAL----TWLGWFNSAI 589

Human   540 NPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQY 573
            ||..||..:..||..| ..|.|:......:|.|:
  Fly   590 NPFIYAFYSVDFRAAF-WRLTCKRFFSAGQKPQF 622

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CHRM3NP_000731.1 7tmA_mAChR_M3 66..>270 CDD:320426 70/205 (34%)
TM helix 1 70..96 CDD:320426 8/25 (32%)
TM helix 2 103..130 CDD:320426 10/26 (38%)
TM helix 3 141..171 CDD:320426 12/29 (41%)
TM helix 4 183..206 CDD:320426 7/23 (30%)
TM helix 5 228..257 CDD:320426 9/28 (32%)
Basolateral sorting signal 275..281 3/5 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..357 9/48 (19%)
7tm_GPCRs <484..564 CDD:475119 28/84 (33%)
TM helix 6 490..512 CDD:320426 9/21 (43%)
TM helix 7 523..548 CDD:320426 9/24 (38%)
TyrRNP_650652.1 7tmA_tyramine_R-like 118..>304 CDD:320189 67/191 (35%)
TM helix 1 118..144 CDD:320189 8/25 (32%)
TM helix 2 151..177 CDD:320189 10/25 (40%)
TM helix 3 189..219 CDD:320189 12/29 (41%)
TM helix 4 232..255 CDD:320189 6/22 (27%)
TM helix 5 272..297 CDD:320189 7/25 (28%)
7tm_GPCRs <533..605 CDD:475119 25/75 (33%)
TM helix 6 539..561 CDD:320189 9/21 (43%)
TM helix 7 573..598 CDD:320189 9/28 (32%)

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